Selective inhibition of electrical conduction within the pulmonary veins by α1-adrenergic receptors activation in the Rat - Archive ouverte HAL Access content directly
Journal Articles Scientific Reports Year : 2020

Selective inhibition of electrical conduction within the pulmonary veins by α1-adrenergic receptors activation in the Rat

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Abstract

Pulmonary veins (PV) are involved in the pathophysiology of paroxysmal atrial fibrillation. In the rat, left atrium (LA) and PV cardiomyocytes have different reactions to α1-adrenergic receptor activation. In freely beating atria-PV preparations, we found that electrical field potential (EFP) originated from the sino-atrial node propagated through the LA and the PV. The α1-adrenergic receptor agonist cirazoline induced a progressive loss of EFP conduction in the PV whereas it was maintained in the LA. This could be reproduced in preparations electrically paced at 5 Hz in LA. During pacing at 10 Hz in the PV where high firing rate ectopic foci can occur, cirazoline stopped EFP conduction from the PV to the LA, which allowed the sino-atrial node to resume its pace-making function. Loss of conduction in the PV was associated with depolarization of the diastolic membrane potential of PV cardiomyocytes. Adenosine, which reversed the cirazoline-induced depolarization of the diastolic membrane potential of PV cardiomyocytes, restored full over-shooting action potentials and EFP conduction in the PV. In conclusion, selective activation of α1-adrenergic receptors results in the abolition of electrical conduction within the PV. These results highlight a potentially novel pharmacological approach to treat paroxysmal atrial fibrillation by targeting directly the PV myocardium.
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Dates and versions

inserm-02538836 , version 1 (09-04-2020)

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Pierre Bredeloux, Ian Findlay, Côme Pasqualin, Mélèze Hocini, Olivier Bernus, et al.. Selective inhibition of electrical conduction within the pulmonary veins by α1-adrenergic receptors activation in the Rat. Scientific Reports, 2020, 10 (1), pp.5390. ⟨10.1038/s41598-020-62349-5⟩. ⟨inserm-02538836⟩
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