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Intra-tumoral tertiary lymphoid structures are associated with a low risk of early recurrence of hepatocellular carcinoma

Abstract : Intra-tumoral tertiary lymphoid structures are associated with a low risk of early recurrence of hepatocellular carcinoma Graphical abstract Authors Decreased risk of early HCC relapse HCC TLS In situ antigen presentation and promotion of anti-tumor immunity Highlights Intra-tumoral tertiary lymphoid structures are associated with decreased risk of early HCC relapse after surgery. Presence of intra-tumoral tertiary lymphoid structures is not linked to the etiology of the underlying liver disease. Our study suggests that tertiary lymphoid structures reflect ongoing, effective anti-tumor immunity. Lay summary Tertiary lymphoid structures provide a critical microenvironment for generating anti-tumor immune responses, and are associated with improved clinical outcome in most cancers investigated. Their role in hepatocellular carcinoma is however debated. We show in the present study that intra-tumoral tertiary lym-phoid structures are associated with a low risk of early relapse after surgical resection, suggesting that they reflect the existence of in situ, effective anti-tumor immunity. http://dx.
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https://www.hal.inserm.fr/inserm-02536028
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Submitted on : Tuesday, April 7, 2020 - 7:38:28 PM
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Julien Calderaro, Florent Petitprez, Etienne Becht, Alexis Laurent, Theo Hirsch, et al.. Intra-tumoral tertiary lymphoid structures are associated with a low risk of early recurrence of hepatocellular carcinoma. J. Hepatol., 2019, 70 (1), pp.58-65. ⟨10.1016/j.jhep.2018.09.003⟩. ⟨inserm-02536028⟩

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