Skip to Main content Skip to Navigation
Journal articles

Molecular and histological correlations in liver cancer

Abstract : Hepatocellular carcinoma (HCC) is a highly heterogeneous cancer, both at the molecular and histological level. High-throughput sequencing and gene expression profiling have identified distinct transcriptomic subclasses and numerous recurrent genetic alterations; several HCC subtypes characterised by histolog-ical features have also been identified. HCC phenotype appears to be closely related to particular gene mutations, tumour subgroups and/or oncogenic pathways. Non-proliferative tumours display a well-differentiated phenotype. Among this molecular subgroup, CTNNB1-mutated HCCs constitute a homogeneous subtype, exhibiting cholestasis and microtrabecular and pseudoglandular architectural patterns. Another non-proliferative subtype has a gene expression pattern similar to that of mature hepatocytes (G4) and displays a steatohepatitic phenotype. In contrast, proliferative HCCs are most often poorly differentiated , and notably include tumours with progenitor features. A novel morphological variant of pro-liferative HCC-designated ''macrotrabecular-massive"-was recently shown to be associated with angiogenesis activation and poor prognosis. Altogether, these findings may help to translate our knowledge of HCC biology into clinical practice, resulting in improved precision medicine for patients with this highly aggressive malignancy. This manuscript reviews the most recent data in this exciting field, discussing future directions and challenges.
Complete list of metadata

Cited literature [135 references]  Display  Hide  Download
Contributor : Jessica Zucman-Rossi Connect in order to contact the contributor
Submitted on : Tuesday, April 7, 2020 - 7:37:10 PM
Last modification on : Tuesday, October 19, 2021 - 4:10:45 PM


 Restricted access
To satisfy the distribution rights of the publisher, the document is embargoed until : jamais

Please log in to resquest access to the document



Julien Calderaro, Marianne Ziol, Valérie Paradis, Jessica Zucman-Rossi. Molecular and histological correlations in liver cancer. Journal of Hepatology, Elsevier, 2019, 71 (3), pp.616-630. ⟨10.1016/j.jhep.2019.06.001⟩. ⟨inserm-02536027⟩



Record views