Coexpression of T4 and T8 on peripheral blood T cells demonstrated by twocolor fluorescence flow cytometry, The Journal of Immunology, vol.134, pp.2281-2286, 1985. ,
Peripheral CD4+CD8+ T cells are differentiated effector memory cells with antiviral functions, Blood, vol.104, pp.478-486, 2004. ,
Distinct CD4+ CD8+ double-positive T cells in the blood and liver of patients during chronic hepatitis B and C, PLoS ONE, vol.6, p.20145, 2011. ,
Potent HIV-specific responses are enriched in a unique subset of CD8+ T cells that coexpresses CD4 on its surface, Blood, vol.114, pp.3841-3853, 2009. ,
Expression of programmed cell death protein 1 and T-cell immunoglobulin-and mucin-domain-containing molecule-3 on peripheral blood CD4+CD8+ double positive T cells in patients with chronic hepatitis C virus infection and in subjects who spontaneously cleared the virus, Journal of Viral Hepatitis, vol.26, pp.942-950, 2019. ,
Peripheral CD4CD8 double positive T cells with a distinct helper cytokine profile are increased in rheumatoid arthritis, PLoS ONE, vol.9, p.93293, 2014. ,
Analysis of CD4+ CD8+ double-positive T cells in blood, cerebrospinal fluid and multiple sclerosis lesions, Clin. Exp. Immunol, vol.177, pp.404-411, 2014. ,
Isolation of tumor-specific cytotoxic CD4+ and CD4+CD8dim+ T-cell clones infiltrating a cutaneous T-cell lymphoma, Blood, vol.91, pp.4331-4341, 1998. ,
Increased frequency of nonconventional double positive CD4CD8 alphabeta T cells in human breast pleural effusions, Int. J. Cancer, vol.125, pp.374-380, 2009. ,
Double Positive CD4CD8 ?? T Cells: A New Tumor-Reactive Population in Human Melanomas, PLOS ONE, vol.5, p.8437, 2010. ,
A double-positive CD4+CD8+ T-cell population is commonly found in nodular lymphocyte predominant Hodgkin lymphoma, Am. J. Clin. Pathol, vol.126, pp.805-814, 2006. ,
Tumor-reactive CD4+ CD8??+ CD103+ ??T cells: a prevalent tumor-reactive T-cell subset in metastatic colorectal cancers, Int. J. Cancer, vol.128, pp.2923-2932, 2011. ,
Double Positive CD4+CD8+ T Cells Are Enriched in Urological Cancers and Favor T Helper-2 Polarization, Front. Immunol, vol.10, 2019. ,
Renal Cell Carcinoma (RCC) Tumors Display Large Expansion of Double Positive (DP) CD4+CD8+ T Cells With Expression of Exhaustion Markers, Front. Immunol, vol.9, 2018. ,
CD4+ CD8+ double positive (DP) T cells in health and disease, Autoimmun Rev, vol.3, pp.215-220, 2004. ,
Multiple populations of T lymphocytes are distinguished by the level of CD4 and CD8 coexpression and require individual consideration, J. Leukoc. Biol, vol.79, pp.4-6, 2006. ,
An important regulatory role for CD4+CD8?? T cells in the intestinal epithelial layer in the prevention of inflammatory bowel disease, PNAS, vol.100, pp.5324-5329, 2003. ,
Upregulation of CD4 on CD8+ T cells: CD4dimCD8bright T cells constitute an activated phenotype of CD8+ T cells, Immunology, vol.103, pp.270-280, 2001. ,
Activation of CD8 T cells induces expression of CD4, which functions as a chemotactic receptor, Blood, vol.99, pp.207-212, 2002. ,
CD40L confers helper functions to human intra-melanoma class-I-restricted CD4+CD8+ double positive T cells, Oncoimmunology, vol.5, p.1250991, 2016. ,
URL : https://hal.archives-ouvertes.fr/inserm-01702809
CRTAM determines the CD4+ cytotoxic T lymphocyte lineage, J. Exp. Med, vol.213, pp.123-138, 2016. ,
T memory stem cells in health and disease, Nat. Med, vol.23, pp.18-27, 2017. ,
T cell anergy, exhaustion, senescence, and stemness in the tumor microenvironment, Curr. Opin. Immunol, vol.25, pp.214-221, 2013. ,
Increased expression of the NK cell receptor KLRG1 by virus-specific CD8 T cells during persistent antigen stimulation, J. Virol, vol.79, pp.12112-12116, 2005. ,
Interaction of KLRG1 with E-cadherin: new functional and structural insights, Eur. J. Immunol, vol.38, pp.3354-3364, 2008. ,
TCF1 expression marks self-renewing human CD8+ T cells, Blood Adv, vol.2, pp.1685-1690, 2018. ,
CD8+ T Cell Priming in Established Chronic Viral Infection Preferentially Directs Differentiation of Memory-like Cells for Sustained Immunity, Immunity, vol.49, pp.678-694, 2018. ,
The Transcription Factor TCF1 Preserves the Effector Function of Exhausted CD8 T Cells During Chronic Viral Infection, Front. Immunol, vol.10, p.169, 2019. ,
Chemokines in the cancer microenvironment and their relevance in cancer immunotherapy, Nat. Rev. Immunol, vol.17, pp.559-572, 2017. ,
CD4 Helper and CD8 Cytotoxic T Cell Differentiation, Annu. Rev. Immunol, vol.36, pp.579-601, 2018. ,
The chromatin landscape and transcription factors in T cell programming, Trends Immunol, vol.35, pp.195-204, 2014. ,
The transcription factor Zbtb7b promotes CD4 expression by antagonizing Runx-mediated activation of the CD4 silencer, J. Immunol, vol.179, pp.4405-4414, 2007. ,
Epigenetic silencing of CD8 genes by ThPOK-mediated deacetylation during CD4 T cell differentiation, J. Immunol, vol.189, pp.1380-1390, 2012. ,
The zinc finger transcription factor Zbtb7b represses CD8-lineage gene expression in peripheral CD4+ T cells, Immunity, vol.29, pp.876-887, 2008. ,
A ThPOK-LRF transcriptional node maintains the integrity and effector potential of post-thymic CD4+ T cells, Nat. Immunol, vol.15, pp.947-956, 2014. ,
ThPOK represses CXXC5, which induces methylation of histone H3 lysine 9 in Cd40lg promoter by association with SUV39H1: implications in repression of CD40L expression in CD8+ cytotoxic T cells, Journal of Leukocyte Biology, vol.100, pp.327-338, 2016. ,
Repression of the transcription factor Th-POK by Runx complexes in cytotoxic T cell development, Science, vol.319, pp.822-825, 2008. ,
Runx3 and T-box proteins cooperate to establish the transcriptional program of effector CTLs, J. Exp. Med, vol.206, pp.51-59, 2009. ,
Mutual expression of the transcription factors Runx3 and ThPOK regulates intestinal CD4+ T cell immunity, Nat. Immunol, vol.14, pp.271-280, 2013. ,
Stabilisation of ?-Catenin Downstream of T Cell Receptor Signalling, PLOS ONE, vol.5, p.12794, 2010. ,
, Catenin Signaling Mediates CD4 Expression on Mature CD8+ T Cells, vol.185, pp.2013-2019, 2010.
Tcf1 and Lef1 pack their own HDAC, Nat. Immunol, vol.17, pp.615-616, 2016. ,
High avidity melanoma-reactive cytotoxic T lymphocytes are efficiently induced from peripheral blood lymphocytes on stimulation by peptide-pulsed melanoma cells, Clin. Cancer Res, vol.6, pp.1459-1467, 2000. ,
URL : https://hal.archives-ouvertes.fr/inserm-02482162
Linear models and empirical bayes methods for assessing differential expression in microarray experiments, Stat. Appl. Genet. Mol. Biol, vol.3, p.3, 2004. ,
limma powers differential expression analyses for RNA-sequencing and microarray studies, Nucleic Acids Res, vol.43, p.47, 2015. ,
Should We Abandon the t-Test in the Analysis of Gene Expression Microarray Data: A Comparison of Variance Modeling Strategies, Plos one, vol.5, 2010. ,
URL : https://hal.archives-ouvertes.fr/hal-00539115
Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles, Proc. Natl. Acad. Sci. USA, vol.102, pp.15545-15550, 2005. ,
PGC-1alpha-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes, Nat. Genet, vol.34, pp.267-273, 2003. ,