, Analysis and interpretations of data: Moukengue, B; Brown HK
, , p.631
,
, Writing, review, and/or revision of the manuscript: Moukengue, B; Brown HK, p.633
,
Recent advances in the 642 management of osteosarcoma and forthcoming therapeutic strategies, Expert Rev Anticancer Ther, vol.643, issue.2, pp.169-81, 2007. ,
Chemotherapy, en bloc resection, 645 and prosthetic bone replacement in the treatment of osteogenic sarcoma, Cancer, vol.37, issue.1, pp.1-11, 1976. ,
Osteosarcoma in Korean children and adolescents, Korean J Pediatr, vol.58, issue.4, pp.123-647, 2015. ,
Review of the molecular pathogenesis 649 of osteosarcoma, Asian Pac J Cancer Prev, vol.15, issue.15, pp.5967-76, 2014. ,
Biology of Bone Sarcomas and 651 New Therapeutic Developments, Calcif Tissue Int, vol.102, issue.2, pp.174-95, 2018. ,
Nitrogen mustard therapy; use of methyl-bis (beta-653 chloroethyl) amine hydrochloride and tris (beta-chloroethyl) amine hydrochloride for Hodgkin's 654 disease, lymphosarcoma, leukemia and certain allied and miscellaneous disorders, J Am Med Assoc, vol.655, pp.126-158, 1946. ,
Some observations on the effect of folic acid antagonists on acute leukemia and 657 other forms of incurable cancer, Blood, vol.4, issue.2, pp.160-167, 1949. ,
DNA-damaging agents in cancer chemotherapy: 659 serendipity and chemical biology, Chem Biol, vol.20, issue.5, pp.648-59, 2013. ,
The PARP inhibitor olaparib 661 potentiates the effect of the DNA damaging agent doxorubicin in osteosarcoma, J Exp Clin Cancer 662 Res, vol.37, issue.1, p.107, 2018. ,
Induction of reactive oxygen species: an emerging approach for 664 cancer therapy, Apoptosis, vol.22, issue.11, p.11, 2017. ,
Programmed cell death triggered by 666 nucleotide pool damage and its prevention by MutT homolog-1 (MTH1) with oxidized purine 667 nucleoside triphosphatase, Mutat Res, vol.703, issue.1, p.12, 2010. ,
MTH1 as a nucleotide pool sanitizing enzyme: Friend or 669 foe?, Free Radic Biol Med, vol.107, pp.151-159, 2017. ,
Human MTH1 protein hydrolyzes 671 the oxidized ribonucleotide, 2-hydroxy-ATP, Nucleic Acids Res, vol.29, issue.2, p.14, 2001. ,
Oxidative Stress: 673 Harms and Benefits for Human Health, Oxid Med Cell Longev, vol.674, p.15, 2017. ,
Reactive oxygen species in cancer, Free Radic Res, vol.44, issue.5, p.16, 2010. ,
ROS signalling in the biology of cancer, Semin Cell Dev Biol, vol.676, p.17, 2018. ,
Reactive oxygen species in tumor progression, Front Biosci, vol.10, pp.1881-96, 2005. ,
Addiction to MTH1 protein 679 results in intense expression in human breast cancer tissue as measured by liquid chromatography-680 isotope-dilution tandem mass spectrometry, DNA Repair (Amst), vol.33, p.19, 2015. ,
Oxidative stress 682 and 8-oxoguanine repair are enhanced in colon adenoma and carcinoma patients, Mutagenesis, vol.683, issue.5, pp.463-71, 2010. ,
Spontaneous 685 tumorigenesis in mice defective in the MTH1 gene encoding 8-oxo-dGTPase, Proc Natl Acad Sci, vol.98, issue.20, pp.11456-61, 2001. ,
MTH1 inhibition 688 eradicates cancer by preventing sanitation of the dNTP pool, Nature, vol.508, issue.7495, p.22, 2014. ,
Validation 690 and development of MTH1 inhibitors for treatment of cancer, Ann Oncol, vol.27, issue.12, p.23, 2016. ,
Stereospecific targeting of 692 MTH1 by (S)-crizotinib as an anticancer strategy, Nature, vol.508, issue.7495, p.24, 2014. ,
Anticancer effect of (S)-crizotinib on 694 osteosarcoma cells by targeting MTH1 and activating reactive oxygen species, Anticancer Drugs, vol.695, issue.4, p.25, 2018. ,
Proteomic profiling 697 of small-molecule inhibitors reveals dispensability of MTH1 for cancer cell survival, J Med Chem, vol.698, issue.6, p.27, 2016. ,
MTH1 as a Chemotherapeutic Target: The Elephant in the 702 Room, Cancers (Basel), vol.9, issue.5, 2017. ,
Identification of potent 704 and selective MTH1 inhibitors, Bioorg Med Chem Lett, vol.26, issue.6, p.29, 2016. ,
706 Inhibition of BET proteins and epigenetic signaling as a potential treatment for osteoporosis, Bone, vol.707, p.30, 2017. ,
Continuous elimination of 709 oxidized nucleotides is necessary to prevent rapid onset of cellular senescence, Proc Natl Acad Sci, vol.106, issue.1, pp.169-74, 2009. ,
Direct detection of 8-oxodeoxyguanosine and 8-712 oxoguanine by avidin and its analogues, Anal Biochem, vol.255, issue.1, p.32, 1998. ,
Monitoring 714 drug target engagement in cells and tissues using the cellular thermal shift assay, Science, vol.715, issue.6141, pp.84-91, 2013. ,
ATM phosphorylates histone H2AX in 717 response to DNA double-strand breaks, J Biol Chem, vol.276, issue.45, p.34, 2001. ,
Genome Instability and gammaH2AX. Int 719, J Mol Sci, vol.18, issue.9, 2017. ,
Enhanced elimination of 721 oxidized guanine nucleotides inhibits oncogenic RAS-induced DNA damage and premature 722 senescence, Oncogene, vol.30, issue.12, p.36, 2011. ,
Cancer phenotypic lethality, exemplified by the non-essential MTH1 enzyme 724 being required for cancer survival, Ann Oncol, vol.25, issue.7, p.37, 2014. ,
Glioblastoma and 726 glioblastoma stem cells are dependent on functional MTH1, Oncotarget, vol.8, issue.49, p.38, 2017. ,
Potent and specific MTH1 inhibitors targeting 728 gastric cancer, Cell Death Dis, vol.10, issue.6, pp.434-729, 2019. ,
MTH1 promotes 730 mitotic progression to avoid oxidative DNA damage in cancer cells, bioRxiv, vol.575290, p.40, 2019. ,
MTH1 deficiency selectively 732 increases non-cytotoxic oxidative DNA damage in lung cancer cells: more bad news than good? BMC 733 Cancer, vol.18, 2018. ,
The presumed MTH1-738 inhibitor TH588 sensitizes colorectal carcinoma cells to ionizing radiation in hypoxia, 736 Sci Rep, vol.9, issue.1, p.1190, 2018. ,
Histone H2A variants 741 H2AX and H2AZ, Curr Opin Genet Dev, vol.12, issue.2, p.44, 2002. ,
Isolation of 743 circulating tumor cells in a preclinical model of osteosarcoma: Effect of chemotherapy, J Bone Oncol, vol.744, p.45, 2018. ,
Prognostic and clinicopathological significance 746 of circulating tumor cells in osteosarcoma, J Bone Oncol, vol.16, p.46, 2019. ,
748 hMTH1 is required for maintaining migration and invasion potential of human thyroid cancer cells, DNA Repair (Amst), vol.749, pp.53-62, 2018. ,