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Advances in melanoma senescence and potential clinical application

Abstract : Normal cells possess a limited proliferative life span, after which they enter a state of irreversible growth arrest, called replicative senescence, which acts as a potent barrier against transformation. Transformed cells have escaped the process of replicative senescence and theoretically can not re-enter senescence. However, recent observations showed that transformed cells, and particularly the melanoma cells, can still undergo oncogene or stress-induced senescence. This senescence state is accompanied by many of the markers associated with replicative senescence, such as flattened shape, increased acidic β-galactosidase activity, characteristic changes in gene expression and growth arrest. Interestingly, in some cancers, senescence induction following chemotherapy has been correlated with a favorable patient outcome. In this review, we gathered recent results describing senescence-like phenotype induction in melanoma cells and discuss why senescence may also be exploited as a therapeutic strategy in melanoma.
Keywords : Melanoma Senescence
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Sandy Giuliano, Mickaël Ohanna, Robert Ballotti, Corine Bertolotto. Advances in melanoma senescence and potential clinical application. Pigment Cell & melanoma research, Blackwell Munksgaard, 2011, 24 (2), pp.295-308. ⟨10.1111/j.1755-148X.2010.00820.x⟩. ⟨inserm-02530650⟩



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