Metformin Blocks Melanoma Invasion and Metastasis Development in AMPK/p53-Dependent Manner - Archive ouverte HAL Access content directly
Journal Articles Molecular Cancer Therapeutics Year : 2013

Metformin Blocks Melanoma Invasion and Metastasis Development in AMPK/p53-Dependent Manner

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Abstract

Metformin was reported to inhibit the proliferation of many cancer cells, including melanoma cells. In this report, we investigated the effect of metformin on melanoma invasion and metastasis development. Using different in vitro approaches, we found that metformin inhibits cell invasion without affecting cell migration and independently of antiproliferation action. This inhibition is correlated with modulation of expression of proteins involved in epithelial-mesenchymal transition such as Slug, Snail, SPARC, fibronectin, and N-cadherin and with inhibition of MMP-2 and MMP-9 activation. Furthermore, our data indicate that this process is dependent on activation of AMPK and tumor suppressor protein p53. Finally, we showed that metformin inhibits melanoma metastasis development in mice using extravasation and metastasis models. The presented data reinforce the fact that metformin might be a good candidate for clinical trial in melanoma treatment.
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Dates and versions

inserm-02530614 , version 1 (03-04-2020)

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M. Cerezo, M. Tichet, P. Abbe, M. Ohanna, A. Lehraiki, et al.. Metformin Blocks Melanoma Invasion and Metastasis Development in AMPK/p53-Dependent Manner. Molecular Cancer Therapeutics, 2013, 12 (8), pp.1605-1615. ⟨10.1158/1535-7163.MCT-12-1226-T⟩. ⟨inserm-02530614⟩
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