Molecular characterization of melanocyte stem cells in their niche, Development, vol.132, issue.24, pp.5589-5599, 2005. ,
Notch1 and Notch2 receptors influence progressive hair graying in a dosedependent manner, Developmental Dynamics, vol.236, issue.1, pp.282-289, 2007. ,
Sox10 regulates the development of neural crest-derived melanocytes in Xenopus, Developmental Biology, vol.259, issue.1, pp.19-33, 2003. ,
Pax3 functions at a nodal point in melanocyte stem cell differentiation, Nature, vol.433, issue.7028, pp.884-887, 2005. ,
Notch signaling via Hes1 transcription factor maintains survival of melanoblasts and melanocyte stem cells, Journal of Cell Biology, vol.173, issue.3, pp.333-339, 2006. ,
Regulation of pigment cell-specific gene expression by MITF, Pigment Cell Research, vol.13, issue.8, pp.98-102, 2000. ,
Induction of melanocyte-specific microphthalmia-associated transcription factor by Wnt-3a, Journal of Biological Chemistry, vol.275, issue.19, pp.14013-14016, 2000. ,
Piebaldism: a brief report and review of the literature, Indian Dermatology Online Journal, vol.3, issue.2, pp.144-147, 2012. ,
Melanocyte biology and skin pigmentation, Nature, vol.445, issue.7130, pp.843-850, 2007. ,
Generating quiescent stem cells, Pigment Cell Research, vol.20, issue.4, pp.263-270, 2007. ,
Defining the epithelial stem cell Niche in skin, Science, vol.303, issue.5656, pp.359-363, 2004. ,
Central role of p53 in the suntan response and pathologic hyperpigmentation, Cell, vol.128, issue.5, pp.853-864, 2007. ,
The melanocortin-1 receptor is a key regulator of human cutaneous pigmentation, Pigment Cell Research, vol.13, issue.8, pp.156-162, 2000. ,
Microphthalmia gene product as a signal transducer in cAMP-induced differentiation of melanocytes, Journal of Cell Biology, vol.142, issue.3, pp.827-835, 1998. ,
Microphthalmia-associated transcription factor (MITF) is required but is not sufficient to induce the expression of melanogenic genes, Pigment Cell Research, vol.16, issue.4, pp.374-382, 2003. ,
Novel MITF targets identified using a two-step DNA microarray strategy, Pigment Cell & Melanoma Research, vol.21, issue.6, pp.665-676, 2008. ,
The microphthalmia transcription factor (Mitf) controls expression of the ocular albinism type 1 gene: link between melanin synthesis and melanosome biogenesis, Molecular and Cellular Biology, vol.24, issue.15, pp.6550-6559, 2004. ,
Regulation of tyrosinase gene expression by cAMP in B16 melanoma cells involves two CATGTG motifs surrounding the TATA box: implication of the microphthalmia gene product, Journal of Cell Biology, vol.134, issue.3, pp.747-755, 1996. ,
Different cis-acting elements are involved in the regulation of TRP1 and TRP2 promoter activities by cyclic AMP: pivotal role of M boxes (GTCATGTGCT) and of microphthalmia, Molecular and Cellular Biology, vol.18, issue.2, pp.694-702, 1998. ,
Microphthalmiaassociated transcription factor regulates RAB27A gene expression and controls melanosome transport, Journal of Biological Chemistry, vol.283, issue.18, pp.12635-12642, 2008. ,
URL : https://hal.archives-ouvertes.fr/hal-02358833
Cyclic AMP promotes a peripheral distribution of melanosomes and stimulates melanophilin/Slac2-a actin association, FASEB Journal, vol.18, issue.9, pp.989-991, 2004. ,
URL : https://hal.archives-ouvertes.fr/inserm-02531092
Accelerated ultraviolet radiation-induced carcinogenesis in hepatocyte growth factor/scatter factor transgenic mice, Cancer Research, vol.60, issue.14, pp.3738-3743, 2000. ,
Single UVB overexposure stimulates melanocyte proliferation in murine skin, in contrast to fractionated or UVA-1 exposure, Journal of Investigative Dermatology, vol.124, issue.1, pp.241-247, 2005. ,
Murine neonatal melanocytes exhibit a heightened proliferative response to ultraviolet radiation and migrate to the epidermal basal layer, Journal of Investigative Dermatology, vol.129, issue.1, pp.184-193, 2009. ,
Role of keratinocyte-derived factors involved in regulating the proliferation and differentiation of mammalian epidermal melanocytes, Pigment Cell Research, vol.18, issue.1, pp.2-12, 2005. ,
Ras mediates the cAMPdependent activation of extracellular signal-regulated kinases (ERKs) in melanocytes, EMBO Journal, vol.19, issue.12, pp.2900-2910, 2000. ,
Bcl2 regulation by the melanocyte master regulator Mitf modulates lineage survival and melanoma cell viability, Cell, vol.109, issue.6, pp.707-718, 2002. ,
BCL2A1 is a lineage-specific antiapoptotic melanoma oncogene that confers resistance to BRAF inhibition, Proceedings of the National Academy of Sciences of the United States of Amrica, vol.110, pp.4321-4326, 2013. ,
Microphthalmia-associated transcription factor is a critical transcriptional regulator of melanoma inhibitor of apoptosis in melanomas, Cancer Research, vol.68, issue.9, pp.3124-3132, 2008. ,
Essential role of microphthalmia transcription factor for DNA replication, mitosis and genomic stability in melanoma, Oncogene, vol.30, issue.20, pp.2319-2332, 2011. ,
URL : https://hal.archives-ouvertes.fr/inserm-02530755
Sunlight and vitamin D for bone health and prevention of autoimmune diseases, cancers, and cardiovascular disease, The American Journal of Clinical Nutrition, vol.80, issue.6, pp.1678-1688, 2004. ,
Vitamin D: importance in the prevention of cancers, type 1 diabetes, heart disease, and osteoporosis, American Journal of Clinical Nutrition, vol.79, issue.3, pp.362-371, 2004. ,
Distinct sets of genetic alterations in melanoma, New England Journal of Medicine, vol.353, issue.20, pp.2135-2147, 2005. ,
Melanoma risk in congenital melanocytic naevi: a systematic review, British Journal of Dermatology, vol.155, issue.1, pp.1-8, 2006. ,
Germline p16 mutations in familial melanoma, Nature Genetics, vol.8, issue.1, pp.15-21, 1994. ,
Germline mutations in the p16(INK4a) binding domain of CDK4 in familial melanoma, Nature Genetics, vol.12, issue.1, pp.97-99, 1996. ,
Genetic and environmental factors in cutaneous malignant melanoma, Biochimie, vol.84, issue.1, pp.67-74, 2002. ,
MC1R variants increase melanoma risk in families with CDKN2A mutations: a meta-analysis, European Journal of Cancer, vol.46, issue.8, pp.1413-1420, 2010. ,
A SUMOylationdefective MITF germline mutation predisposes to melanoma and renal carcinoma, Nature, vol.480, issue.7375, pp.94-98, 2011. ,
URL : https://hal.archives-ouvertes.fr/hal-01791271
Prevalence of the E318K MITF germline mutation in Italian melanoma patients: associations with histological subtypes and family cancer history, Pigment Cell & Melanoma Research, vol.26, issue.2, pp.259-262, 2013. ,
Phenotypic characterization of nevus and tumor patterns in MITF E318K mutation carrier melanoma patients, Journal of Investigative Dermatology, 2013. ,
A novel recurrent mutation in MITF predisposes to familial and sporadic melanoma, Nature, vol.480, issue.7375, pp.99-103, 2011. ,
Increased risk of second primary cancers after a diagnosis of melanoma, Archives of Dermatology, vol.146, issue.3, pp.265-272, 2010. ,
Neonatal sunburn and melanoma in mice, Nature, vol.413, issue.6853, pp.271-272, 2001. ,
Site-specific risk of cutaneous malignant melanoma and pattern of sun exposure in New Zealand, International Journal of Cancer, vol.85, issue.5, pp.627-632, 2000. ,
UVAinduced cyclobutane pyrimidine dimers in DNA: a direct photochemical mechanism?, Organic and Biomolecular Chemistry, vol.8, issue.7, pp.1706-1711, 2010. ,
URL : https://hal.archives-ouvertes.fr/hal-00472822
Plasma lipoproteins as mediators of the oxidative stress induced by UV light in human skin: a review of biochemical and biophysical studies on mechanisms of apolipoprotein alteration, lipid peroxidation, and associated skin cell responses, Oxidative Medicine and Cellular Longevity, vol.2013, 2013. ,
Ultraviolet B but not ultraviolet A radiation initiates melanoma, Cancer Research, vol.64, issue.18, pp.6372-6376, 2004. ,
Xeroderma pigmentosum, Orphanet Journal of Rare Diseases, vol.6, issue.1, p.70, 2011. ,
URL : https://hal.archives-ouvertes.fr/inserm-00436508
High expression of DNA repair pathways is associated with metastasis in melanoma patients, Oncogene, vol.27, issue.5, pp.565-573, 2008. ,
URL : https://hal.archives-ouvertes.fr/hal-00281489
TP53 mutations in human skin cancers, Human Mutation, vol.21, issue.3, pp.217-228, 2003. ,
URL : https://hal.archives-ouvertes.fr/hal-02148397
Patterns of somatic mutation in human cancer genomes, Nature, vol.446, issue.7132, pp.153-158, 2007. ,
A comprehensive catalogue of somatic mutations from a human cancer genome, Nature, vol.463, issue.7278, pp.191-196, 2010. ,
8-Hydroxyguanine, an abundant form of oxidative DNA damage, causes G ? T and A ? C substitutions, Journal of Biological Chemistry, vol.267, issue.1, pp.166-172, 1992. ,
Melanoma genome sequencing reveals frequent PREX2 mutations, Nature, vol.485, issue.7399, pp.502-506, 2012. ,
A landscape of driver mutations in melanoma, Cell, vol.150, issue.2, pp.251-263, 2012. ,
Exome sequencing identifies recurrent somatic RAC1 mutations in melanoma, Nature Genetics, vol.44, issue.9, pp.1006-1014, 2012. ,
Genome-wide association studies in cancer, Human Molecular Genetics, vol.17, issue.2, pp.109-115, 2008. ,
Polygenic susceptibility to breast cancer and implications for prevention, Nature Genetics, vol.31, issue.1, pp.33-36, 2002. ,
Comprehensive analysis of CDKN2A (p16INK4A/p14ARF) and CDKN2B genes in 53 melanoma index cases considered to be at heightened risk of melanoma, Journal of Medical Genetics, vol.43, issue.1, pp.39-47, 2006. ,
Cutaneous melanoma in the era of molecular profiling, The Lancet, vol.374, issue.9687, pp.362-365, 2009. ,
Melanoma and genetics, Clinics in Dermatology, vol.27, issue.1, pp.46-52, 2009. ,
Mechanisms of cyclin-dependent kinase regulation: structures of Cdks, their cyclin activators, and Cip and INK4 inhibitors, Journal of Molecular Biology, vol.287, issue.5, pp.821-828, 1999. ,
How to make a melanoma: what do we know of the primary clonal events, Pigment Cell & Melanoma Research, vol.21, issue.1, pp.27-38, 2008. ,
Cellular senescence in naevi and immortalisation in melanoma: a role for p16, British Journal of Cancer, vol.95, issue.4, pp.496-505, 2006. ,
p16/cyclin-dependent kinase inhibitor 2A deficiency in human melanocyte senescence, apoptosis, and immortalization: possible implications for melanoma progression, Journal of the National Cancer Institute, vol.95, issue.10, pp.723-732, 2003. ,
Restoration of CDKN2A into melanoma cells induces morphologic changes and reduction in growth rate but not anchorage-independent growth reversal, Journal of Investigative Dermatology, vol.109, issue.1, pp.61-68, 1997. ,
Metastasizing melanoma formation caused by expression of activated N-RasQ61K on an INK4a-deficient background, Cancer Research, vol.65, issue.10, pp.4005-4011, 2005. ,
A melanoma-associated germline mutation in exon 1 inactivates p14ARF, Oncogene, vol.20, issue.39, pp.5543-5547, 2001. ,
Germline mutation of ARF in a melanoma kindred, Human Molecular Genetics, vol.11, issue.11, pp.1273-1279, 2002. ,
A germline deletion of p14ARF but not CDKN2A in a melanomaneural system tumour syndrome family, Human Molecular Genetics, vol.10, issue.1, pp.55-62, 2001. ,
Frequent p16-independent inactivation of p14ARF in human melanoma, Journal of the National Cancer Institute, vol.100, issue.11, pp.784-795, 2008. ,
ARF functions as a melanoma tumor suppressor by inducing p53-independent senescence, Proceedings of the National Academy of Sciences of the United States of America, vol.104, pp.10968-10973, 2007. ,
Both products of the mouse INK4a/ARF locus suppress melanoma formation in vivo, Oncogene, vol.22, issue.32, pp.5055-5059, 2003. ,
BRAF alterations are associated with complex mutational profiles in malignant melanoma, Oncogene, vol.23, issue.35, pp.5968-5977, 2004. ,
Prevalence of p16 and CDK4 germline mutations in 48 melanoma-prone families in France. The French Familial Melanoma Study Group, Human Molecular Genetics, vol.7, issue.2, pp.209-216, 1998. ,
Germ line transmission of the Cdk4R24C mutation facilitates tumorigenesis and escape from cellular senescence, Molecular and Cellular Biology, vol.22, issue.2, pp.644-656, 2002. ,
Cooperativity of Cdk4R24C and Ras in melanoma development, Cell Cycle, vol.9, issue.16, pp.3305-3314, 2010. ,
Invasive melanoma in Cdk4-targeted mice, Proceedings of the National Academy of Sciences of the United States of America, vol.98, pp.13312-13317, 2001. ,
Melanocytes and the Microphthalmia transcription factor network, Annual Review of Genetics, vol.38, pp.365-411, 2004. ,
Fifteen-year quest for microphthalmia-associated transcription factor target genes, Pigment Cell & Melanoma Research, vol.23, issue.1, pp.27-40, 2010. ,
URL : https://hal.archives-ouvertes.fr/inserm-02530740
Integrative genomic analyses identify MITF as a lineage survival oncogene amplified in malignant melanoma, Nature, vol.436, issue.7047, pp.117-122, 2005. ,
Microphthalmiaassociated transcription factor gene amplification in metastatic melanoma is a prognostic marker for patient survival, but not a predictive marker for chemosensitivity and chemotherapy response, Clinical Cancer Research, vol.13, issue.21, pp.6344-6350, 2007. ,
Mitf regulation of Dia1 controls melanoma proliferation and invasiveness, Genes and Development, vol.20, issue.24, pp.3426-3439, 2006. ,
Mitf is the key molecular switch between mouse or human melanoma initiating cells and their differentiated progeny, Oncogene, vol.30, issue.20, pp.2307-2318, 2011. ,
URL : https://hal.archives-ouvertes.fr/inserm-02530763
Hypoxia and MITF control metastatic behaviour in mouse and human melanoma cells, Oncogene, vol.31, issue.19, pp.2461-2470, 2012. ,
URL : https://hal.archives-ouvertes.fr/inserm-02530643
Cancer stem cells versus phenotype-switching in melanoma, Pigment Cell & Melanoma Research, vol.23, issue.6, pp.746-759, 2010. ,
Mitf cooperates with Rb1 and activates p21Cip1 expression to regulate cell cycle progression, Nature, vol.433, issue.7027, pp.764-769, 2005. ,
URL : https://hal.archives-ouvertes.fr/hal-01068395
Microphthalmiaassociated transcription factor controls the DNA damage response and a lineage-specific senescence program in melanomas, Cancer Research, vol.70, issue.9, pp.3813-3822, 2010. ,
URL : https://hal.archives-ouvertes.fr/inserm-02530789
Advances in melanoma senescence and potential clinical application, Pigment Cell & Melanoma Research, vol.24, issue.2, pp.295-308, 2011. ,
URL : https://hal.archives-ouvertes.fr/inserm-02530650
Senescent cells develop a PARP-1 and nuclear factor-B-associated secretome (PNAS), Genes and Development, vol.25, issue.12, pp.1245-1261, 2011. ,
URL : https://hal.archives-ouvertes.fr/inserm-02530715
MAP kinase links the transcription factor Microphthalmia to c-Kit signalling in melanocytes, Nature, vol.391, issue.6664, pp.298-301, 1998. ,
Regulation of microphthalmia-associated transcription factor MITF protein levels by association with the ubiquitin-conjugating enzyme hUBC9, Experimental Cell Research, vol.255, issue.2, pp.135-143, 2000. ,
Mechanisms, regulation and consequences of protein SUMOylation, Biochemical Journal, vol.428, issue.2, pp.133-145, 2010. ,
Critical role of CDK2 for melanoma growth linked to its melanocyte-specific transcriptional regulation by MITF, Cancer Cell, vol.6, issue.6, pp.565-576, 2004. ,
Up-regulation of MET expression by -melanocyte-stimulating hormone and MITF allows hepatocyte growth factor to protect melanocytes and melanoma cells from apoptosis, Journal of Biological Chemistry, vol.282, issue.19, pp.14140-14147, 2007. ,
URL : https://hal.archives-ouvertes.fr/hal-02358861
Hypoxia-inducible factor 1 is a new target of microphthalmia-associated transcription factor (MITF) in melanoma cells, Journal of Cell Biology, vol.170, issue.1, pp.49-59, 2005. ,
MiTF regulates cellular response to reactive oxygen species through transcriptional regulation of APE-1/Ref-1, Journal of Investigative Dermatology, vol.129, issue.2, pp.422-431, 2009. ,
Mitf dosage as a primary determinant of melanocyte survival after ultraviolet irradiation, Pigment Cell & Melanoma Research, vol.22, issue.3, pp.307-318, 2009. ,
Transcriptional regulation of the melanoma prognostic marker melastatin (TRPM1) by MITF in melanocytes and melanoma, Cancer Research, vol.64, issue.2, pp.509-516, 2004. ,
Oncogenic BRAF regulates oxidative metabolism via PGC1alpha and MITF, Cancer Cell, vol.23, issue.3, pp.302-315, 2013. ,
PGC1alpha expression defines a subset of human melanoma tumors with increased mitochondrial capacity and resistance to oxidative stress, Cancer Cell, vol.23, issue.3, pp.287-301, 2013. ,
Peroxisome proliferatoractivated receptor coactivator 1 coactivators, energy homeostasis, and metabolism, Endocrine Reviews, vol.27, issue.7, pp.728-735, 2006. ,
The melanocortin 1 receptor (MC1R): more than just red hair, Pigment Cell Research, vol.13, issue.3, pp.135-140, 2000. ,
Skin colour and skin cancer-MC1R, the genetic link, Melanoma Research, vol.12, issue.5, pp.405-416, 2002. ,
Melanocortin 1 receptor (MC1R) gene variants are associated with an increased risk for cutaneous melanoma which is largely independent of skin type and hair color, Journal of Investigative Dermatology, vol.117, issue.2, pp.294-300, 2001. ,
Melanocortin-1 receptor polymorphisms and risk of melanoma: is the association explained solely by pigmentation phenotype?, American Journal of Human Genetics, vol.66, issue.1, pp.176-186, 2000. ,
Variants of the melanocyte-stimulating hormone receptor gene are associated with red hair and fair skin in humans, Nature Genetics, vol.11, issue.3, pp.328-330, 1995. ,
MC1R genotype modifies risk of melanoma in families segregating CDKN2A mutations, American Journal of Human Genetics, vol.69, issue.4, pp.765-773, 2001. ,
Melanocortin-1 receptor variant R151C modifies melanoma risk in Dutch families with melanoma, American Journal of Human Genetics, vol.69, issue.4, pp.774-779, 2001. ,
MC1R variants increase risk of melanomas harboring BRAF mutations, Journal of Investigative Dermatology, vol.128, pp.2485-2490, 2008. ,
MC1R germline variants confer risk for BRAF-mutant melanoma, Science, vol.313, issue.5786, pp.521-522, 2006. ,
ASIP and TYR pigmentation variants associate with cutaneous melanoma and basal cell carcinoma, Nature Genetics, vol.40, issue.7, pp.886-891, 2008. ,
SLC45A2: a novel malignant melanoma-associated gene, Human Mutation, vol.29, issue.9, pp.1161-1167, 2008. ,
Polymorphisms in nevus-associated genes MTAP, PLA2G6, and IRF4 and the risk of invasive cutaneous melanoma, Twin Research and Human Genetics, vol.14, issue.5, pp.422-432, 2011. ,
TERT promoter mutations in familial and sporadic melanoma, Science, vol.339, issue.6122, pp.959-961, 2013. ,
Exome sequencing identifies GRIN2A as frequently mutated in melanoma, Nature Genetics, vol.43, issue.5, pp.442-448, 2011. ,
Analysis of the tyrosine kinome in melanoma reveals recurrent mutations in ERBB4, Nature Genetics, vol.41, issue.10, pp.1127-1132, 2009. ,
Analysis of the matrix metalloproteinase family reveals that MMP8 is often mutated in melanoma, Nature Genetics, vol.41, issue.5, pp.518-520, 2009. ,
Phox homology band 4.1/ezrin/radixin/moesin-like proteins function as molecular scaffolds that interact with cargo receptors and Ras GTPases, Proceedings of the National Academy of Sciences of the United States of America, vol.108, issue.19, pp.7763-7768, 2011. ,
Transforming acidic coiled coil 1 promotes transformation and mammary tumorigenesis, Cancer Research, vol.65, issue.22, pp.10363-10370, 2005. ,
High frequency of BRAF mutations in nevi, Nature Genetics, vol.33, issue.1, pp.19-20, 2003. ,
Clonal BRAF mutations in melanocytic nevi and initiating role of BRAF in melanocytic neoplasia, Journal of the National Cancer Institute, vol.105, issue.12, pp.917-919, 2013. ,
Use of human tissue to assess the oncogenic activity of melanoma-associated mutations, Nature Genetics, vol.37, issue.7, pp.745-749, 2005. ,
Hypoxia, melanocytes and melanoma-survival and tumor development in the permissive microenvironment of the skin, Pigment Cell & Melanoma Research, vol.22, issue.2, pp.166-174, 2009. ,
Molecular diagnostics in Melanoma: current status and perspectives, Archives of Pathology and Laboratory Medicine, vol.135, issue.7, pp.860-869, 2011. ,
Antioncogenic role of the endoplasmic reticulum differentially activated by mutations in the MAPK pathway, Nature Cell Biology, vol.8, issue.10, pp.1053-1063, 2006. ,
BRAFE600-associated senescence-like cell cycle arrest of human naevi, Nature, vol.436, issue.7051, pp.720-724, 2005. ,
BrafV600E cooperates with Pten loss to induce metastatic melanoma, Nature Genetics, vol.41, issue.5, pp.544-552, 2009. ,
Oncogenic braf induces melanocyte senescence and melanoma in mice, Cancer Cell, vol.15, issue.4, pp.294-303, 2009. ,
catenin signaling controls metastasis in braf-activated ptendeficient melanomas, Cancer Cell, vol.20, issue.6, pp.741-754, 2011. ,
The melanomas: a synthesis of epidemiological, clinical, histopathological, genetic, and biological aspects, supporting distinct subtypes, causal pathways, and cells of origin, Pigment Cell & Melanoma Research, vol.24, issue.5, pp.879-897, 2011. ,
BRAF and NRAS mutations in melanoma: potential relationships to clinical response to HSP90 inhibitors, Molecular Cancer Therapeutics, vol.7, issue.4, pp.737-739, 2008. ,
Clinical correlates of NRAS and BRAF mutations in primary human melanoma, Clinical Cancer Research, vol.17, issue.2, pp.229-235, 2011. ,
Analysis of mutations in B-RAF, N-RAS, and H-RAS genes in the differential diagnosis of Spitz nevus and spitzoid melanoma, American Journal of Surgical Pathology, vol.29, issue.9, pp.1145-1151, 2005. ,
Mutations of the BRAF gene in human cancer, Nature, vol.417, issue.6892, pp.949-954, 2002. ,
NRAS mutation status is an independent prognostic factor in metastatic melanoma, Cancer, vol.118, issue.16, pp.4014-4023, 2012. ,
Coexisting NRAS and BRAF mutations in primary familial melanomas with specific CDKN2A germline alterations, Journal of Investigative Dermatology, vol.130, issue.2, pp.618-620, 2010. ,
Oncogenic BRAF regulates melanoma proliferation through the lineage specific factor MITF, PLoS ONE, vol.3, issue.7, 2008. ,
Malignant transformation of melanocytes to melanoma by constitutive activation of mitogen-activated protein kinase kinase (MAPKK) signaling, Journal of Biological Chemistry, vol.278, issue.11, pp.9790-9795, 2003. ,
Novel Ras antagonist blocks human melanoma growth, Proceedings of the National Academy of Sciences of the United States of America, vol.96, pp.14019-14024, 1999. ,
Suppression of BRAFV599E in human melanoma abrogates transformation, Cancer Research, vol.63, issue.17, pp.5198-5202, 2003. ,
Oncogenic BRAF is required for tumor growth and maintenance in melanoma models, Cancer Research, vol.66, issue.2, pp.999-1006, 2006. ,
Targeting mitogenactivated protein kinase/extracellular signal-regulated kinase kinase in the mutant (V600E) B-Raf signaling cascade effectively inhibits melanoma lung metastases, Cancer Research, vol.66, issue.16, pp.8200-8209, 2006. ,
A switch in the expression of embryonic EMT-inducers drives the Development of Malignant Melanoma, Cancer Cell, vol.24, issue.4, pp.466-480, 2013. ,
Oncogene abnormalities in a series of primary melanomas of the sinonasal tract: NRAS mutations and cyclin D1 amplification are more frequent than KIT or BRAF mutations, Human Pathology, vol.44, issue.9, pp.1902-1911, 2013. ,
URL : https://hal.archives-ouvertes.fr/inserm-00872629
Cyclin D1 is a candidate oncogene in cutaneous melanoma, Cancer Research, vol.62, issue.11, pp.3200-3206, 2002. ,
Increased cyclin D1 expression can mediate BRAF inhibitor resistance in BRAF V600E-mutated melanomas, Molecular Cancer Therapeutics, vol.7, issue.9, pp.2876-2883, 2008. ,
Pharmacodynamic effects and mechanisms of resistance to vemurafenib in patients with metastatic melanoma, Journal of Clinical Oncology, vol.31, issue.14, pp.1767-1774, 2013. ,
Adhesion control of cyclin D1 and p27Kip1 levels is deregulated in melanoma cells through BRAF-MEK-ERK signaling, Oncogene, vol.24, issue.21, pp.3459-3471, 2005. ,
Distinctive role of the cKit receptor tyrosine kinase signaling in mammalian melanocytes, Journal of Investigative Dermatology, vol.126, issue.5, pp.1102-1110, 2006. ,
In utero manipulation of coat color formation by a monoclonal antic-kit antibody: two distinct waves of c-kit-dependency during melanocyte development, EMBO Journal, vol.10, issue.8, pp.2111-2118, 1991. ,
Effects of monoclonal anti-c-Kit antibody (ACK2) on melanocytes in newborn mice, Journal of Investigative Dermatology, vol.105, issue.3, pp.322-328, 1995. ,
KIT receptor is expressed in more than 50% of early-stage malignant melanoma: a retrospective study of 261 patients, Melanoma Research, vol.15, issue.4, pp.251-256, 2005. ,
Driving transcriptional regulators in melanoma metastasis, Cancer and Metastasis Reviews, vol.31, issue.3-4, pp.621-632, 2012. ,
Role of AP-2 in tumor growth and metastasis of human melanoma, Cancer and Metastasis Reviews, vol.18, issue.3, pp.377-385, 1999. ,
Tumor suppressor activity of AP2 mediated through a direct interaction with p53, Journal of Biological Chemistry, vol.277, issue.47, pp.45028-45033, 2002. ,
L576P KIT mutation in anal melanomas correlates with KIT protein expression and is sensitive to specific kinase inhibition, International Journal of Cancer, vol.121, issue.2, pp.257-264, 2007. ,
KIT gene mutations and copy number in melanoma subtypes, Clinical Cancer Research, vol.14, issue.21, pp.6821-6828, 2008. ,
Somatic activation of KIT in distinct subtypes of melanoma, Journal of Clinical Oncology, vol.24, issue.26, pp.4340-4346, 2006. ,
BRAF and c-kit gene copy number in mutationpositive malignant melanoma, Human Pathology, vol.37, issue.5, pp.520-527, 2006. ,
Loss of AP-2 results in downregulation of c-KIT and enhancement of melanoma tumorigenicity and metastasis, EMBO Journal, vol.17, issue.15, pp.4358-4369, 1998. ,
Identification of a novel subgroup of melanomas with KIT/cyclindependent kinase-4 overexpression, Cancer Research, vol.68, issue.14, pp.5743-5752, 2008. ,
Blinded by the light: the growing complexity of p53, Cell, vol.137, issue.3, pp.413-431, 2009. ,
Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours, Nature, vol.356, issue.6366, pp.215-221, 1992. ,
Molecular pathogenesis of cutaneous melanocytic neoplasms, Annual Review of Pathology, vol.4, pp.551-579, 2009. ,
Dual inactivation of RB and p53 pathways in RASinduced melanomas, Molecular and Cellular Biology, vol.21, issue.6, pp.2144-2153, 2001. ,
Oncogenic NRAS cooperates with p53 loss to generate melanoma in zebrafish, Zebrafish, vol.6, issue.4, pp.397-404, 2009. ,
Melanocytic nevus-like hyperplasia and melanoma in transgenic BRAFV600E mice, Oncogene, vol.28, issue.23, pp.2289-2298, 2009. ,
BRAF mutations are sufficient to promote nevi formation and cooperate with p53 in the genesis of melanoma, Current Biology, vol.15, issue.3, pp.249-254, 2005. ,
Inactivation of the apoptosis effector Apaf-1 in malignant melanoma, Nature, vol.409, issue.6817, pp.207-211, 2001. ,
The role of BRAF mutation and p53 inactivation during transformation of a subpopulation of primary human melanocytes, American Journal of Pathology, vol.174, issue.6, pp.2367-2377, 2009. ,
Amplification of CDK4 and MDM2 in malignant melanoma, Genes Chromosomes and Cancer, vol.45, issue.5, pp.447-454, 2006. ,
MDM4 is a key therapeutic target in cutaneous melanoma, Nature Medicine, vol.18, issue.8, pp.1239-1247, 2012. ,
The hypoxic microenvironment of the skin contributes to Akt-mediated melanocyte transformation, Cancer Cell, vol.8, issue.6, pp.443-454, 2005. ,
DNA damage is a prerequisite for p53-mediated proteasomal degradation of HIF-1 in hypoxic cells and downregulation of the hypoxia marker carbonic anhydrase IX, Molecular and Cellular Biology, vol.24, issue.13, pp.5757-5766, 2004. ,
A p53/miRNA-34 axis regulates Snail1-dependent cancer cell epithelial-mesenchymal transition, Journal of Cell Biology, vol.195, issue.3, pp.417-433, 2011. ,
p53 regulates epithelialmesenchymal transition through microRNAs targeting ZEB1 and ZEB2, Journal of Experimental Medicine, vol.208, issue.5, pp.875-883, 2011. ,
,
Management of cutaneous melanoma, New England Journal of Medicine, vol.351, issue.10, pp.998-1042, 2004. ,
Loss of PTEN promotes tumor development in malignant melanoma, Cancer Research, vol.63, issue.11, pp.2881-2890, 2003. ,
Deregulated Akt3 activity promotes development of malignant melanoma, Cancer Research, vol.64, issue.19, pp.7002-7010, 2004. ,
Novel somatic mutations to PI3K pathway genes in metastatic melanoma, PLoS ONE, vol.7, issue.8, 2012. ,
Examination of mutations in BRAF, NRAS, and PTEN in primary cutaneous melanoma, Journal of Investigative Dermatology, vol.126, issue.1, pp.154-160, 2006. ,
Epithelial-mesenchymal transition in development and cancer: role of phosphatidylinositol 3 kinase/AKT pathways, Oncogene, vol.24, issue.50, pp.7443-7454, 2005. ,
GM3 upregulation of matrix metalloproteinase-9 possibly through PI3K, AKT, RICTOR, RHOGDI-2, and TNF-a pathways in mouse melanoma B16 cells, Advances in Experimental Medicine and Biology, vol.705, pp.335-348, 2011. ,
Matrix metalloproteinases in tumor invasion and metastasis, Seminars in Cancer Biology, vol.10, issue.6, pp.415-433, 2000. ,
Cancer stem cells and EMT in carcinoma, Cancer and Metastasis Reviews, vol.31, issue.1-2, pp.285-293, 2012. ,
Snail silencing effectively suppresses tumour growth and invasiveness, Oncogene, vol.26, issue.13, pp.1862-1874, 2007. ,
Snail, ZEB and bHLH factors in tumour progression: an alliance against the epithelial phenotype?, Nature Reviews Cancer, vol.7, issue.6, pp.415-428, 2007. ,
Epithelial-mesenchymal transitions in development and disease, Cell, vol.139, issue.5, pp.871-890, 2009. ,
Epithelial-mesenchymal transition: at the crossroads of development and tumor metastasis, Developmental Cell, vol.14, issue.6, pp.818-829, 2008. ,
A high-throughput study in melanoma identifies epithelial-mesenchymal transition as a major determinant of metastasis, Cancer Research, vol.67, issue.7, pp.3450-3460, 2007. ,
The transcription factor Snail is a repressor of E-cadherin gene expression in epithelial tumour cells, Nature Cell Biology, vol.2, issue.2, pp.84-89, 2000. ,
The SLUG zinc-finger protein represses E-cadherin in breast cancer, Cancer Research, vol.62, issue.6, pp.1613-1618, 2002. ,
Twist, a master regulator of morphogenesis, plays an essential role in tumor metastasis, Cell, vol.117, issue.7, pp.927-939, 2004. ,
The melanocyte differentiation program predisposes to metastasis after neoplastic transformation, Nature Genetics, vol.37, issue.10, pp.1047-1054, 2005. ,
Reexpression of E-cadherin, alpha-catenin and beta-catenin, but not of gamma-catenin, in metastatic tissue from breast cancer patients [seecomments], Journal of Pathology, vol.190, issue.1, pp.15-19, 2000. ,
E-cadherin expression in melanoma cells restores keratinocyte-mediated growth control and down-regulates expression of invasion-related adhesion receptors, American Journal of Pathology, vol.156, issue.5, pp.1515-1525, 2000. ,
Heterogeneity of expression of epithelial-mesenchymal transition markers in melanocytes and melanoma cell lines, Frontiers in Genetics, vol.4, p.97, 2013. ,
Akt enhances Mdm2-mediated ubiquitination and degradation of p53, Journal of Biological Chemistry, vol.277, issue.24, pp.21843-21850, 2002. ,
P53 regulates epithelialmesenchymal transition and stem cell properties through modulating miRNAs, Nature Cell Biology, vol.13, issue.3, pp.317-323, 2011. ,
A Wnt-Axin2-GSK3 cascade regulates Snail1 activity in breast cancer cells, Nature Cell Biology, vol.8, issue.12, pp.1398-1406, 2006. ,
Rac1b and reactive oxygen species mediate MMP-3-induced EMT and genomic instability, Nature, vol.436, issue.7047, pp.123-127, 2005. ,
Dual regulation of Snail by GSK-3 -mediated phosphorylation in control of epithelialmesenchymal transition, Nature Cell Biology, vol.6, issue.10, pp.931-940, 2004. ,
Stable overexpression of Smad7 in human melanoma cells inhibits their tumorigenicity in vitro and in vivo, Oncogene, vol.24, issue.51, pp.7624-7629, 2005. ,
URL : https://hal.archives-ouvertes.fr/inserm-00147458
TGFbeta in cancer, Cell, vol.134, issue.2, pp.215-230, 2008. ,
Induction of sonic hedgehog mediators by transforming growth factor-: smad3-dependent activation of Gli2 and Gli1 expression in vitro and in vivo, Cancer Research, vol.67, issue.14, pp.6981-6986, 2007. ,
URL : https://hal.archives-ouvertes.fr/inserm-00194393
GLI2 cooperates with ZEB1 for transcriptional repression of CDH1 expression in human melanoma cells, Pigment Cell & Melanoma Research, vol.26, issue.6, pp.861-873, 2013. ,
Insights into the transforming growth factor-beta signaling pathway in cutaneous melanoma, Annals of Dermatology, vol.25, issue.2, pp.135-144, 2013. ,
The Wnt signaling pathway in development and disease, Annual Review of Cell and Developmental Biology, vol.20, pp.781-810, 2004. ,
Brn-2 expression controls melanoma proliferation and is directly regulated bycatenin, Molecular and Cellular Biology, vol.24, issue.7, pp.2915-2922, 2004. ,
Identification of c-MYC as a target of the APC pathway, Science, vol.281, issue.5382, pp.1509-1512, 1998. ,
The cyclin D1 gene is a target of the -catenin/LEF-1 pathway, Proceedings of the National Academy of Sciences of the United States of America, vol.96, pp.5522-5527, 1999. ,
Frequent nuclear/cytoplasmic localization of -catenin without exon 3 mutations in malignant melanoma, American Journal of Pathology, vol.154, issue.2, pp.325-329, 1999. ,
Molecular genetic analysis of malignant melanomas for aberrations of the wnt signaling pathway genes CTNNB1, APC, ICAT and BTRC, International Journal of Cancer, vol.100, issue.5, pp.549-556, 2002. ,
Catenin induces immortalization of melanocytes by suppressing p16INK4a expression and cooperates with N-Ras in melanoma development, Genes and Development, vol.21, issue.22, pp.2923-2935, 2007. ,
The gene expression signatures of melanoma progression, Proceedings of the National Academy of Sciences of the United States of America, vol.102, pp.6092-6097, 2005. ,
Expression of Dickkopf genes is strongly reduced in malignant melanoma, Oncogene, vol.25, issue.36, pp.5027-5036, 2006. ,
Wnt inhibitory factor-1 gene transfer inhibits melanoma cell growth, Human Gene Therapy, vol.18, issue.4, pp.379-386, 2007. ,
Dickkopf-1 activates cell death in MDA-MB435 melanoma cells, Biochemical and Biophysical Research Communications, vol.352, issue.3, pp.675-680, 2007. ,
Activated Wnt/ -catenin signaling in melanoma is associated with decreased proliferation in patient tumors and a murine melanoma model, Proceedings of the National Academy of Sciences of the United States of America, vol.106, issue.4, pp.1193-1198, 2009. ,
Metastatic potential of melanomas defined by specific gene expression profiles with no BRAF signature, Pigment Cell Research, vol.19, issue.4, pp.290-302, 2006. ,
Wnt/ -catenin signaling and AXIN1 regulate apoptosis triggered by inhibition of the mutant kinase BRAFV600E in human melanoma, Science Signaling, vol.5, issue.206, p.3, 2012. ,
The Wnt5A/protein kinase C pathway mediates motility in melanoma cells via the inhibition of metastasis suppressors and initiation of an epithelial to mesenchymal transition, Journal of Biological Chemistry, vol.282, issue.23, pp.17259-17271, 2007. ,
Wnt5a signaling directly affects cell motility and invasion of metastatic melanoma, Cancer Cell, vol.1, issue.3, pp.279-288, 2002. ,
Rho and RAC take center stage, Cell, vol.116, issue.2, pp.167-179, 2004. ,
GTP-binding proteins of the Rho/Rac family: regulation, effectors and functions in vivo, BioEssays, vol.29, issue.4, pp.356-370, 2007. ,
Rac1 in the driver's seat for melanoma, Pigment Cell & Melanoma Research, vol.25, issue.6, pp.762-764, 2012. ,
RAC1P29S is a spontaneously activating cancer-associated GTPase, Proceedings of the National Academy of Sciences of the United States of Amrica, vol.110, pp.912-917, 2013. ,
P-Rex1 is required for efficient melanoblast migration and melanoma metastasis, Nature Communications, vol.2, p.555, 2011. ,
Activated mutant NRas(Q61K) drives aberrant melanocyte signaling, survival, and invasiveness via a Rac1-dependent mechanism, Journal of Investigative Dermatology, vol.132, issue.11, pp.2610-2621, 2012. ,
Discovery and development of sorafenib: a multikinase inhibitor for treating cancer, Nature Reviews Drug Discovery, vol.5, issue.10, pp.835-844, 2006. ,
Improved survival with vemurafenib in melanoma with BRAF V600E mutation, New England Journal of Medicine, vol.364, issue.26, pp.2507-2516, 2011. ,
Resistance to BRAF-targeted therapy in melanoma, European Journal of Cancer, vol.49, issue.6, pp.1297-1304, 2013. ,
Cutaneous toxicities of RAF inhibitors, The Lancet Oncology, vol.14, issue.1, pp.11-18, 2013. ,
RAF inhibitors transactivate RAF dimers and ERK signalling in cells with wild-type BRAF, Nature, vol.464, issue.7287, pp.427-430, 2010. ,
Dabrafenib in BRAF-mutated metastatic melanoma: a multicentre, openlabel, phase 3 randomised controlled trial, The Lancet, vol.380, issue.9839, pp.358-365, 2012. ,
MEK162 for patients with advanced melanoma harbouring NRAS or Val600 BRAF mutations: a non-randomised, open-label phase 2 study, The Lancet Oncology, vol.14, issue.3, pp.249-256, 2013. ,
Improved survival with MEK inhibition in BRAF-mutated melanoma, New England Journal of Medicine, vol.367, issue.2, pp.107-114, 2012. ,
Phase II, openlabel, randomized trial of the MEK1/2 inhibitor selumetinib as monotherapy versus temozolomide in patients with advanced melanoma, Clinical Cancer Research, vol.18, issue.2, pp.555-567, 2012. ,
Secondary c-Kit mutations confer acquired resistance to RTK inhibitors in c-Kit mutant melanoma cells, Pigment Cell & Melanoma Research, vol.26, issue.4, pp.518-526, 2013. ,
Imatinib targeting of KITmutant oncoprotein in melanoma, Clinical Cancer Research, vol.14, issue.23, pp.7726-7732, 2008. ,
Lack of clinical efficacy of imatinib in metastatic melanoma, British Journal of Cancer, vol.92, issue.8, pp.1398-1405, 2005. ,
Multicenter phase II trial of high-dose imatinib mesylate in metastatic melanoma: significant toxicity with no clinical efficacy, Cancer, vol.106, issue.9, 2005. ,
Major response to imatinib mesylate in KIT-mutated melanoma, Journal of Clinical Oncology, vol.26, issue.12, pp.2046-2051, 2008. ,
Dose-dependent, complete response to imatinib of a metastatic mucosal melanoma with a K642E KIT mutation, Pigment Cell & Melanoma Research, vol.21, issue.4, pp.492-493, 2008. ,
Imatinib for melanomas harboring mutationally activated or amplified KIT arising on mucosal, acral, and chronically sun-damaged skin, Journal of Clinical Oncology, vol.31, issue.26, pp.3182-3190, 2013. ,
Focus on TILs: prognostic significance of tumor infiltrating lymphocytes in human melanoma, Cancer Immunity, vol.9, 2009. ,
Immunotherapy for melanoma: current status and perspectives, Journal of Immunotherapy, vol.33, issue.6, pp.570-590, 2010. ,
Regulation of cell surface expression of CTLA-4 by secretion of CTLA-4-containing lysosomes upon activation of CD4+ T cells, Journal of Immunology, vol.165, issue.9, pp.5062-5068, 2000. ,
Improved survival with ipilimumab in patients with metastatic melanoma, New England Journal of Medicine, vol.363, issue.8, pp.711-723, 2010. ,
Ipilimumab plus dacarbazine for previously untreated metastatic melanoma, New England Journal of Medicine, vol.364, issue.26, pp.2517-2526, 2011. ,
Safety and tumor responses with lambrolizumab (anti-PD-1) in melanoma, New England Journal of Medicine, vol.369, issue.2, pp.134-144, 2013. ,
Nivolumab plus ipilimumab in advanced melanoma, New England Journal of Medicine, vol.369, issue.2, pp.122-133, 2013. ,
Mechanisms of hair graying: incomplete melanocyte stem cell maintenance in the niche, Science, vol.307, issue.5710, pp.720-724, 2005. ,
A dual role for SOX10 in the maintenance of the postnatal melanocyte lineage and the differentiation of melanocyte stem cell progenitors, PLOS Genetics, vol.9, issue.7, 2013. ,
Human dermal stem cells differentiate into functional epidermal melanocytes, Journal of Cell Science, vol.123, issue.6, pp.853-860, 2010. ,
A tumorigenic subpopulation with stem cell properties in melanomas, Cancer Research, vol.65, issue.20, pp.9328-9337, 2005. ,
Melanoma contains CD133 and ABCG2 positive cells with enhanced tumourigenic potential, European Journal of Cancer, vol.43, issue.5, pp.935-946, 2007. ,
Isolation and identification of cancer stem-like cells from murine melanoma cell lines, Cellular & Molecular Immunology, vol.4, issue.6, pp.467-472, 2007. ,
Human melanoma-initiating cells express neural crest nerve growth factor receptor CD271, Nature, vol.466, issue.7302, pp.133-137, 2010. ,
Identification of cells initiating human melanomas, Nature, vol.451, issue.7176, pp.345-349, 2008. ,
ALDH1A isozymes are markers of human melanoma stem cells and potential therapeutic targets, Stem Cells, vol.30, issue.10, pp.2100-2113, 2012. ,
A temporarily distinct subpopulation of slow-cycling melanoma cells is required for continuous tumor growth, Cell, vol.141, issue.4, pp.583-594, 2010. ,
Overcoming intrinsic multidrug resistance in melanoma by blocking the mitochondrial respiratory chain of slow-cycling JARID1B(high) cells, Cancer Cell, vol.23, issue.6, pp.811-825, 2013. ,
ATP-binding cassette transporter ABCB5 gene is expressed with variability in malignant melanoma, Actas Dermo-Sifiliograficas, vol.101, issue.4, pp.341-348, 2010. ,
ABCB5-mediated doxorubicin transport and chemoresistance in human malignant melanoma, Cancer Research, vol.65, issue.10, pp.4320-4333, 2005. ,
Identification of multiple antigens recognized by tumor-infiltrating lymphocytes from a single patient: tumor escape by antigen loss and loss of MHC expression, Journal of Immunotherapy, vol.27, issue.3, pp.184-190, 2004. ,
MLANA/MART1 and SILV/PMEL17/GP100 are transcriptionally regulated by MITF in melanocytes and melanoma, American Journal of Pathology, vol.163, issue.1, pp.333-343, 2003. ,
Finding the missing heritability of complex diseases, Nature, vol.461, issue.7265, pp.747-753, 2009. ,