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Increased soluble and platelet-associated CD40 ligand in essential thrombocythemia and reactive thrombocytosis
Jean-François Viallard
1
Anne Solanilla
2
Bruno Gauthier
Cécile Contin
3
Julie Déchanet
3
Christophe Grosset
4
Jean-François Moreau
3
Vincent Praloran
3
Paquita Nurden
5
Jean-Luc Pellegrin
1
Alan Nurden
5
Jean Ripoche
2
Jean-François Viallard
Cécile Contin
Julie Déchanet
Jean-François Moreau
Jean-François Viallard 1
Author
Anne Solanilla 2
Author
Bruno Gauthier
Author
Cécile Contin 3
Author
Julie Déchanet 3
Author
Christophe F Grosset 4
Author
Jean-François Moreau 3
Author
Vincent Praloran 3
Author
Jean-François Viallard
Author
Cécile Contin
Author
Julie Déchanet
Author
Jean-François Moreau
Author
1
Médecine Interne (33500 PESSAC - France)
- CHU Bordeaux [Bordeaux] (place Amélie Raba Léon 33076 BORDEAUX CEDEX - France)
- Hôpital Haut-Lévêque [CHU Bordeaux] (France)
- CHU Bordeaux [Bordeaux] (place Amélie Raba Léon 33076 BORDEAUX CEDEX - France)
2
Fibrose hépatique et cancer du foie (146, rue Léo Saignat 33076 Bordeaux - France)
- Université Bordeaux Segalen - Bordeaux 2 (146 rue Léo Saignat - 33076 Bordeaux cedex - France)
- IFR66 (France)
- INSERM - Institut National de la Santé et de la Recherche Médicale : E0362 (101, rue de Tolbiac, 75013 Paris - France)
3
CIRID - Composantes innées de la réponse immunitaire et différenciation (bat. 1B 2e étage 146 Rue Léo Saignat - BP 14 33076 BORDEAUX CEDEX - France)
- Université Bordeaux Segalen - Bordeaux 2 (146 rue Léo Saignat - 33076 Bordeaux cedex - France)
- CNRS - Centre National de la Recherche Scientifique : UMR5164 (France)
4
Biothérapies des maladies génétiques et cancers (146 rue Léo Saignat, Bat TP zone sud, 33076 Bordeaux Cedex - France)
- Université Bordeaux Segalen - Bordeaux 2 (146 rue Léo Saignat - 33076 Bordeaux cedex - France)
- INSERM - Institut National de la Santé et de la Recherche Médicale : U1035 (101, rue de Tolbiac, 75013 Paris - France)
5
Service d'hématologie (Place Amélie Rabat-Léon Bordeaux - France)
- CHU Bordeaux [Bordeaux] (place Amélie Raba Léon 33076 BORDEAUX CEDEX - France)
- Hôpital Haut-Lévêque [CHU Bordeaux] (France)
- CHU Bordeaux [Bordeaux] (place Amélie Raba Léon 33076 BORDEAUX CEDEX - France)
Abstract : CD40 ligand (CD40L) is expressed on activated CD4(+) T lymphocytes and at the activated platelet surface. A circulating soluble form of CD40L (sCD40L) is generated by the way of a proteolytic cleavage. We measured sCD40L in the plasma of either healthy subjects; patients with inflammatory disorders and low, normal, or high platelet count (reactive thrombocytosis); or patients with essential thrombocythemia (ET). A tight correlation was found between the platelet count and plasma sCD40L. ET patients had the highest levels of sCD40L. Platelet-associated CD40L was increased in ET and reactive thrombocytosis, conditions associated with increased platelet regeneration. Platelet-associated CD40L was released upon platelet activation. In conclusion, platelets appear as a reservoir of CD40L that may be a major contributor to circulating sCD40L. Platelet-associated CD40L may be a potential marker of platelet regeneration.
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Journal articles
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https://www.hal.inserm.fr/inserm-02519484
Contributor : Christophe Grosset <>
Submitted on : Thursday, March 26, 2020 - 9:49:44 AM
Last modification on : Friday, March 27, 2020 - 1:58:33 AM
Contributor : Christophe Grosset <>
Submitted on : Thursday, March 26, 2020 - 9:49:44 AM
Last modification on : Friday, March 27, 2020 - 1:58:33 AM
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- HAL Id : inserm-02519484, version 1
- DOI : 10.1182/blood.v99.7.2612
- PUBMED : 11895803
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Citation
Jean-François Viallard, Anne Solanilla, Bruno Gauthier, Cécile Contin, Julie Déchanet, et al.. Increased soluble and platelet-associated CD40 ligand in essential thrombocythemia and reactive thrombocytosis. Blood, American Society of Hematology, 2002, 99 (7), pp.2612-2614. ⟨10.1182/blood.v99.7.2612⟩. ⟨inserm-02519484⟩
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