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Increased soluble and platelet-associated CD40 ligand in essential thrombocythemia and reactive thrombocytosis

Abstract : CD40 ligand (CD40L) is expressed on activated CD4(+) T lymphocytes and at the activated platelet surface. A circulating soluble form of CD40L (sCD40L) is generated by the way of a proteolytic cleavage. We measured sCD40L in the plasma of either healthy subjects; patients with inflammatory disorders and low, normal, or high platelet count (reactive thrombocytosis); or patients with essential thrombocythemia (ET). A tight correlation was found between the platelet count and plasma sCD40L. ET patients had the highest levels of sCD40L. Platelet-associated CD40L was increased in ET and reactive thrombocytosis, conditions associated with increased platelet regeneration. Platelet-associated CD40L was released upon platelet activation. In conclusion, platelets appear as a reservoir of CD40L that may be a major contributor to circulating sCD40L. Platelet-associated CD40L may be a potential marker of platelet regeneration.
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https://www.hal.inserm.fr/inserm-02519484
Contributor : Christophe Grosset <>
Submitted on : Thursday, March 26, 2020 - 9:49:44 AM
Last modification on : Friday, March 27, 2020 - 1:58:33 AM

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Jean-François Viallard, Anne Solanilla, Bruno Gauthier, Cécile Contin, Julie Déchanet, et al.. Increased soluble and platelet-associated CD40 ligand in essential thrombocythemia and reactive thrombocytosis. Blood, American Society of Hematology, 2002, 99 (7), pp.2612-2614. ⟨10.1182/blood.v99.7.2612⟩. ⟨inserm-02519484⟩

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