Skip to Main content Skip to Navigation
Journal articles

Expression of thrombopoietin by umbilical vein endothelial cells.

Abstract : Current data suggest that the primary source of thrombopoietin (TPO) is the liver. Extra-hepatic sites for TPO production have been demonstrated essentially through the study of the expression of TPO mRNA. In this work, we report that TPO is expressed at low levels by endothelial cells (EC) derived from the umbilical vein (HUVEC). Both TPO mRNA and the protein are expressed and the protein is functional as assessed by biological assay. Expression of TPO by HUVEC may be useful to study the regulation of the production of this cytokine and to understand the apparent specific interactions between mature megakaryocytes and EC in the bone marrow.
Document type :
Journal articles
Complete list of metadatas

https://www.hal.inserm.fr/inserm-02519481
Contributor : Christophe Grosset <>
Submitted on : Thursday, March 26, 2020 - 9:48:27 AM
Last modification on : Tuesday, June 23, 2020 - 2:28:02 PM

Identifiers

  • HAL Id : inserm-02519481, version 1
  • PUBMED : 11399515

Collections

Citation

A El Andaloussi, P Duchez, J Rieffers, J. Ripoche, C. Grosset. Expression of thrombopoietin by umbilical vein endothelial cells.. European Cytokine Network, John Libbey Eurotext, 2001, 12 (2), pp.268-73. ⟨inserm-02519481⟩

Share

Metrics

Record views

23