, Les auteurs déclarent n'avoir aucun conflit d'intérêt

S. Jonas, Towards a molecular understanding of microRNAmediated gene silencing, Nat Rev Genet, vol.16, issue.7, pp.421-454, 2015.

L. Gebert, Regulation of microRNA function in animals, Nat Rev Mol Cell Biol, vol.20, issue.1, pp.21-37, 2019.

S. Jalvy-delvaille, Molecular basis of differential target regulation by miR-96 and miR-182: the Glypican-3 as a model, Nucleic Acids Res, vol.40, issue.3, pp.1356-65, 2012.
URL : https://hal.archives-ouvertes.fr/inserm-02437939

K. Zhang, A novel class of microRNA-recognition elements that function only within open reading frames, Nat Struct Mol Biol, vol.25, issue.11, pp.1019-1046, 2018.

S. M. Peterson, Common features of microRNA target prediction tools, Front Genet, vol.5, p.23, 2014.

N. K. Singh, MiRNAs target databases: developmental methods and target identification techniques with functional annotations, Cell Mol Life Sci, vol.74, issue.12, pp.2239-61, 2017.

N. Pinzon, MicroRNA target prediction programs predict many false positives, Genome Res, vol.27, issue.2, pp.234-279, 2017.
URL : https://hal.archives-ouvertes.fr/hal-01845045

E. -indersie, Tracking cellular and molecular changes in a species-specific manner during experimental tumor progression in vivo, Oncotarget, vol.9, issue.22, pp.16149-62, 2018.

A. -kozomara, MiRBase: from microRNA sequences to function, Nucleic Acids Res, vol.47, issue.D1, pp.155-62, 2019.

H. Valadi, Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells, Nat Cell Biol, vol.9, issue.6, pp.654-663, 2007.

M. P. Hunter, The fusion of two worlds: non-coding RNAs and extracellular vesicles--diagnostic and therapeutic implications (Review), Int J Oncol, vol.3, issue.11, pp.17-27, 2008.

P. S. Mitchell, Circulating microRNAs as stable bloodbased markers for cancer detection, Proc Natl Acad Sci U S A, vol.105, issue.30, pp.10513-10521, 2008.

G. A. -calin, Frequent deletions and down-regulation of micro-RNA genes miR15 and miR16 at 13q14 in chronic lymphocytic leukemia, Proc Natl Acad Sci, vol.99, issue.24, pp.15524-15533, 2002.

M. Chowdhury and S. , Ultrasound-guided therapeutic modulation of hepatocellular carcinoma using complementary microRNAs, J Control Release, vol.238, pp.272-80, 2016.

G. -dimcevski, A human clinical trial using ultrasound and microbubbles to enhance gemcitabine treatment of inoperable pancreatic cancer, J Control Release, vol.243, pp.172-81, 2016.

W. Wu, A PEGylated megamer-based microRNA delivery system activatable by stepwise microenvironment stimulation, Chem Commun, vol.55, issue.63, pp.9363-9369, 2019.

U. K. -sukumar, Intranasal delivery of targeted polyfunctional gold-iron oxide nanoparticles loaded with therapeutic microRNAs for combined theranostic multimodality imaging and presensitization of glioblastoma to temozolomide, Invest New Drugs, vol.218, issue.2, pp.180-188, 2017.

. -van-zandwijk, Safety and activity of microRNA-loaded minicells in patients with recurrent malignant pleural mesothelioma: a first-in-man, phase 1, open-label, dose-escalation study, Lancet Oncol, vol.18, issue.10, pp.1386-96, 2017.