The spike glycoprotein of the new coronavirus 2019-nCoV contains a furin-like cleavage site absent in CoV of the same clade - Archive ouverte HAL Access content directly
Journal Articles Antiviral Research Year : 2020

The spike glycoprotein of the new coronavirus 2019-nCoV contains a furin-like cleavage site absent in CoV of the same clade

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Abstract

In 2019, a new coronavirus (2019-nCoV) infecting Humans has emerged in Wuhan, China. Its genome has been sequenced and the genomic information promptly released. Despite a high similarity with the genome sequence of SARS-CoV and SARS-like CoVs, we identified a peculiar furin-like cleavage site in the Spike protein of the 2019-nCoV, lacking in the other SARS-like CoVs. In this article, we discuss the possible functional consequences of this cleavage site in the viral cycle, pathogenicity and its potential implication in the development of antivirals.
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inserm-02517696 , version 1 (28-05-2020)

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Attribution - NonCommercial - NoDerivatives - CC BY 4.0

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Bruno Coutard, Coralie Valle, Xavier de Lamballerie, Bruno Canard, Nabil G Seidah, et al.. The spike glycoprotein of the new coronavirus 2019-nCoV contains a furin-like cleavage site absent in CoV of the same clade. Antiviral Research, 2020, 176, pp.104742. ⟨10.1016/j.antiviral.2020.104742⟩. ⟨inserm-02517696⟩
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