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The spike glycoprotein of the new coronavirus 2019-nCoV contains a furin-like cleavage site absent in CoV of the same clade

Abstract : In 2019, a new coronavirus (2019-nCoV) infecting Humans has emerged in Wuhan, China. Its genome has been sequenced and the genomic information promptly released. Despite a high similarity with the genome sequence of SARS-CoV and SARS-like CoVs, we identified a peculiar furin-like cleavage site in the Spike protein of the 2019-nCoV, lacking in the other SARS-like CoVs. In this article, we discuss the possible functional consequences of this cleavage site in the viral cycle, pathogenicity and its potential implication in the development of antivirals.
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Submitted on : Thursday, May 28, 2020 - 11:11:51 AM
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Bruno Coutard, Coralie Valle, Xavier de Lamballerie, Bruno Canard, Nabil Seidah, et al.. The spike glycoprotein of the new coronavirus 2019-nCoV contains a furin-like cleavage site absent in CoV of the same clade. Antiviral Research, Elsevier Masson, 2020, 176, pp.104742. ⟨10.1016/j.antiviral.2020.104742⟩. ⟨inserm-02517696⟩

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