D. Lavanchy, The global burden of hepatitis C, Liver Int, vol.29, issue.1, pp.74-81, 2009.

L. B. Seeff, The history of the "natural history" of hepatitis, Liver Int, vol.29, issue.1, pp.89-99, 1968.

C. Neumann-haefelin and R. Thimme, Adaptive immune responses in hepatitis C virus infection, Curr Top Microbiol Immunol, vol.369, pp.243-62, 2013.

S. M. Horner and M. Gale, Regulation of hepatic innate immunity by hepatitis C virus, Nat Med, vol.19, pp.879-88, 2013.

V. Soriano, M. G. Peters, and S. Zeuzem, New therapies for hepatitis C virus infection, Clin Infect Dis, vol.48, pp.313-333, 2009.

L. Golden-mason and H. R. Rosen, Natural killer cells: multifaceted players with key roles in hepatitis C immunity, Immunol Rev, vol.255, pp.68-81, 2013.

K. A. Stegmann, N. K. Bjorkstrom, and H. Veber, Interferon-alpha-induced TRAIL on natural killer cells is associated with control of hepatitis C virus infection, Gastroenterology, vol.138, pp.1885-97, 2010.

S. Jost and M. Altfeld, Control of human viral infections by natural killer cells, Annu Rev Immunol, vol.31, pp.163-94, 2013.

J. C. Yoon, J. B. Lim, and J. H. Park, Cell-to-cell contact with hepatitis C virus-infected cells reduces functional capacity of natural killer cells, J Virol, vol.85, pp.12557-69, 2011.

K. Cheent and S. I. Khakoo, Natural killer cells and hepatitis C: action and reaction, Gut, vol.60, pp.268-78, 2011.

P. Bonorino, M. Ramzan, and X. Camous, Fine characterization of intrahepatic NK cells expressing natural killer receptors in chronic hepatitis B and C, J Hepatol, vol.51, pp.458-67, 2009.
URL : https://hal.archives-ouvertes.fr/inserm-00405723

N. Kawarabayashi, S. Seki, and K. Hatsuse, Decrease of CD56(+)T cells and natural killer cells in cirrhotic livers with hepatitis C may be involved in their susceptibility to hepatocellular carcinoma, Hepatology, vol.32, pp.962-971, 2000.

S. Varchetta, D. Mele, and S. Mantovani, Impaired intrahepatic natural killer cell cytotoxic function in chronic hepatitis C virus infection, Hepatology, vol.56, pp.841-850, 2012.

H. Fickenscher, S. Hor, and H. Kupers, The interleukin-10 family of cytokines, Trends Immunol, vol.23, pp.89-96, 2002.

W. Ouyang, S. Rutz, and N. K. Crellin, Regulation and functions of the IL-10 family of cytokines in inflammation and disease, Annu Rev Immunol, vol.29, pp.71-109, 2011.

R. Sabat, IL-10 family of cytokines, Cytokine Growth Factor Rev, vol.21, pp.315-339, 2010.

A. Knappe, S. Hor, and S. Wittmann, Induction of a novel cellular homolog of interleukin-10, AK155, by transformation of T lymphocytes with herpesvirus saimiri, J Virol, vol.74, pp.3881-3888, 2000.

O. Braum, H. Pirzer, and H. Fickenscher, Interleukin-26, a highly cationic T-cell cytokine targeting epithelial cells, Antiinflamm Antiallergy Agents Med Chem, vol.11, pp.221-230, 2012.

R. P. Donnelly, F. Sheikh, and H. Dickensheets, Interleukin-26: an IL-10-related cytokine produced by Th17 cells, Cytokine Growth Factor Rev, vol.21, pp.393-401, 2010.

J. Dambacher, F. Beigel, and K. Zitzmann, The role of the novel Th17 cytokine IL-26 in intestinal inflammation, Gut, vol.58, pp.1207-1224, 2009.

F. Sheikh, V. V. Baurin, and A. Lewis-antes, Cutting edge: IL-26 signals through a novel receptor complex composed of IL-20 receptor 1 and IL-10 receptor 2, J Immunol, vol.172, pp.2006-2016, 2004.

S. Hor, H. Pirzer, and L. Dumoutier, The T-cell lymphokine interleukin-26 targets epithelial cells through the interleukin-20 receptor 1 and interleukin-10 receptor 2 chains, J Biol Chem, vol.279, pp.33343-51, 2004.

M. Corvaisier, Y. Delneste, and H. Jeanvoine, IL-26 is overexpressed in rheumatoid arthritis and induces proinflammatory cytokine production and Th17 cell generation, PLoS Biol, vol.10, p.1001395, 2012.

R. P. Donnelly, H. Dickensheets, O. 'brien, and T. R. , Interferon-lambda and therapy for chronic hepatitis C virus infection, Trends Immunol, vol.32, pp.443-50, 2011.

O. Braum, M. Klages, and H. Fickenscher, The cationic Cytokine IL-26 differentially modulates virus infection in culture, PLoS One, vol.8, p.70281, 2013.

D. Duluc, F. Tan, and M. Scotet, PolyI:C plus IL-2 or IL-12 induce IFN-gamma production by human NK cells via autocrine IFN-beta, Eur J Immunol, vol.39, pp.2877-84, 2009.

L. L. Lanier, A. M. Le, and C. I. Civin, The relationship of CD16 (Leu-11) and Leu-19 (NKH-1) antigen expression on human peripheral blood NK cells and cytotoxic T lymphocytes, J Immunol, vol.136, pp.4480-4486, 1986.

K. J. Blight, J. A. Mckeating, and C. M. Rice, Highly permissive cell lines for subgenomic and genomic hepatitis C virus RNA replication, J Virol, vol.76, pp.13001-13015, 2002.

T. Wakita, T. Pietschmann, and T. Kato, Production of infectious hepatitis C virus in tissue culture from a cloned viral genome, Nat Med, vol.11, pp.791-797, 2005.

P. Ferraris, E. Beaumont, and R. Uzbekov, Sequential biogenesis of host cell membrane rearrangements induced by hepatitis C virus infection, Cell Mol Life Sci, vol.70, pp.1297-306, 2013.
URL : https://hal.archives-ouvertes.fr/inserm-00805157

C. E. Samuel, Antiviral actions of interferons, Clin Microbiol Rev, vol.14, pp.778-809, 2001.

B. Rehermann, Pathogenesis of chronic viral hepatitis: differential roles of T cells and NK cells, Nat Med, vol.19, pp.859-68, 2013.

G. Ahlenstiel, R. H. Titerence, and C. Koh, Natural killer cells are polarized toward cytotoxicity in chronic hepatitis C in an interferon-alfa-dependent manner, Gastroenterology, vol.138, pp.325-360, 2010.

K. A. Holder, S. N. Stapleton, and M. E. Gallant, Hepatitis C Virus-infected cells downregulate NKp30 and inhibit ex vivo NK cell functions, J Immunol, vol.191, pp.3308-3326, 2013.

J. Pene, S. Chevalier, and L. Preisser, Chronically inflamed human tissues are infiltrated by highly differentiated Th17 lymphocytes, J Immunol, vol.180, pp.7423-7453, 2008.

N. J. Wilson, K. Boniface, and J. R. Chan, Development, cytokine profile and function of human interleukin 17-producing helper T cells, Nat Immunol, vol.8, pp.950-957, 2007.

Q. Chang, Y. K. Wang, and Q. Zhao, Th17 cells are increased with severity of liver inflammation in patients with chronic hepatitis C, J Gastroenterol Hepatol, vol.27, pp.273-281, 2012.

D. Saadoun, O. Boyer, and H. Trebeden-negre, Predominance of type 1 (Th1) cytokine production in the liver of patients with HCV-associated mixed cryoglobulinemia vasculitis, J Hepatol, vol.41, pp.1031-1038, 2004.

B. Gao and S. Radaeva, Natural killer and natural killer T cells in liver fibrosis, Biochim Biophys Acta, vol.1832, pp.1061-1070, 2013.

M. Eisenhardt, A. Glassner, and B. Kramer, The CXCR3(+)CD56Bright phenotype characterizes a distinct NK cell subset with anti-fibrotic potential that shows dys-regulated activity in hepatitis C, PLoS One, vol.7, p.38846, 2012.

M. H. Heim, Innate immunity and HCV, J Hepatol, vol.58, pp.564-74, 2013.

P. Metz, E. Dazert, and A. Ruggieri, Identification of type I and type II interferoninduced effectors controlling hepatitis C virus replication, Hepatology, vol.56, pp.2082-93, 2012.

K. Hiroishi, T. Ito, and M. Imawari, Immune responses in hepatitis C virus infection and mechanisms of hepatitis C virus persistence, J Gastroenterol Hepatol, vol.23, pp.1473-82, 2008.

H. Zhu and C. Liu, Interleukin-1 inhibits hepatitis C virus subgenomic RNA replication by activation of extracellular regulated kinase pathway, J Virol, vol.77, pp.5493-5501, 2003.

M. L. Nagalakshmi, E. Murphy, and T. Mcclanahan, Expression patterns of IL-10 ligand and receptor gene families provide leads for biological characterization, Int Immunopharmacol, vol.4, pp.577-92, 2004.