L. F. Bancsi, F. J. Broekmans, M. J. Eijkemans, F. H. De-jong, J. D. Habbema et al., Predictors of poor ovarian response in in vitro fertilization: a prospective study comparing basal markers of ovarian reserve, Fertil Steril, vol.77, pp.328-364, 2002.

F. J. Soules-broekmans and B. C. Fauser, Ovarian aging: mechanisms and clinical consequences, Endocr Rev, vol.30, pp.465-93, 2009.

J. Cohen, N. Chabbert-buffet, and E. Darai, Diminished ovarian reserve, premature ovarian failure, poor ovarian responder -a plea for universal definitions, J Assist Reprod Genet, vol.32, pp.1709-1721, 2015.

K. Devine, S. L. Mumford, M. Wu, A. H. Decherney, M. J. Hill et al., Diminished ovarian reserve in the United States assisted reproductive technology population: diagnostic trends among 181,536 cycles from the Society for Assisted Reproductive Technology Clinic Outcomes Reporting System, Fertil Steril, vol.104, pp.612-621, 2015.

S. M. Nelson, E. E. Telfer, and R. A. Anderson, The ageing ovary and uterus: new biological insights, Hum Reprod Update, vol.19, pp.67-83, 2013.

M. J. Eijkemans, F. Van-poppel, D. F. Habbema, K. Smith, H. Leridon et al., Too old to have children? Lessons from natural fertility populations, Hum Reprod, vol.29, pp.1304-1316, 2014.

N. E. Baskind, N. M. Orsi, and V. Sharma, Follicular-phase ovarian follicular fluid and plasma cytokine profiling of natural cycle in vitro fertilization patients, Fertil Steril, vol.102, pp.410-418, 2014.

D. A. Dumesic, D. R. Meldrum, M. G. Katz-jaffe, R. L. Krisher, and W. B. Schoolcraft, Oocyte environment: follicular fluid and cumulus cells are critical for oocyte health, Fertil Steril, vol.103, pp.303-319, 2015.

R. B. Gilchrist, M. Lane, and J. G. Thompson, Oocyte-secreted factors: regulators of cumulus cell function and oocyte quality, Hum Reprod Update, vol.14, pp.159-77, 2008.

L. Pacella, D. L. Zander-fox, D. T. Armstrong, and M. Lane, Women with reduced ovarian reserve or advanced maternal age have an altered follicular environment, Fertil Steril, vol.98, pp.986-94, 2012.

C. Tatone, F. Amicarelli, M. C. Carbone, P. Monteleone, D. Caserta et al., Cellular and molecular aspects of ovarian follicle ageing, Hum Reprod Update, vol.14, pp.131-173, 2008.

S. Vujisic and S. Zidovec, Follicular immunology environment and the influence on in vitro fertilization outcome, Curr Womens Health Rev, vol.1, pp.49-60, 2005.

J. E. Fortune, Ovarian follicular growth and development in mammals, Biol Reprod, vol.50, pp.225-257, 1994.

C. Mcrae, V. Sharma, and J. Fisher, Metabolite profiling in the pursuit of biomarkers for IVF outcome: the case for metabolomics studies, Int J Reprod Med, p.603167, 2013.

A. O'gorman, M. Wallace, E. Cottell, M. J. Gibney, F. M. Mcauliffe et al., Metabolic profiling of human follicular fluid identifies potential biomarkers of oocyte developmental competence, Reproduction, vol.146, pp.389-95, 2013.

A. Revelli, L. Delle-piane, S. Casano, E. Molinari, M. Massobrio et al., Follicular fluid content and oocyte quality: from single biochemical markers to metabolomics, Reprod Biol Endocrinol, vol.7, p.40, 2009.

M. Wallace, E. Cottell, M. J. Gibney, F. M. Mcauliffe, M. Wingfield et al., An investigation into the relationship between the metabolic profile of follicular fluid, oocyte developmental potential, and implantation outcome, Fertil Steril, vol.97, pp.1078-84, 2012.

M. Bedaiwy, A. Y. Shahin, A. M. Abulhassan, J. M. Goldberg, R. K. Sharma et al., Differential expression of follicular fluid cytokines: relationship to subsequent pregnancy in IVF cycles, Reprod Biomed Online, vol.15, pp.321-326, 2007.

N. Lédée, R. Lombroso, L. Lombardelli, J. Selva, S. Dubanchet et al., Cytokines and chemokines in follicular fluids and potential of the corresponding embryo: the role of granulocyte colony-stimulating factor, Hum Reprod, vol.23, pp.2001-2010, 2008.

S. A. Taghavi, M. Ashrafi, M. Mehdizadeh, L. Karimian, M. T. Joghataie et al., Toll-like receptors expression in follicular cells of patients with poor ovarian response, Int J Fertil Steril, vol.8, pp.183-92, 2014.

A. Karaer, G. Tuncay, A. Mumcu, and B. Dogan, Metabolomics analysis of follicular fluid in women with ovarian endometriosis undergoing in vitro fertilization, Syst Biol Reprod Med, vol.65, pp.39-47, 2019.

Y. D. Tan and H. Xu, A general method for accurate estimation of false discovery rates in identification of differentially expressed genes, Bioinformatics, vol.30, pp.2018-2043, 2014.

, Practice Committee of the American Society for Reproductive. Testing and interpreting measures of ovarian reserve: a committee opinion, Fertil Steril, vol.103, pp.9-17, 2015.

M. Caillaud, G. Duchamp, and N. Gérard, In vivo effect of interleukin-1beta and interleukin-1RA on oocyte cytoplasmic maturation, ovulation, and early embryonic development in the mare, Reprod Biol Endocrinol, vol.3, p.26, 2005.

S. Kol, B. W. Donesky, K. Ruutiainen-altman, I. Ben-shlomo, M. Irahara et al., Ovarian interleukin-1 receptor antagonist in rats: gene expression, cellular localization, cyclic variation, and hormonal regulation of a potential determinant of Interleukin-1 action, Biol Reprod, vol.6, pp.274-82, 1999.

H. Xu, A. Schultze-mosgau, A. Agic, K. Diedrich, R. N. Taylor et al., Regulated upon activation, normal T cell expressed and secreted (RANTES) and monocyte chemotactic protein 1 in follicular fluid accumulate differentially in patients with and without endometriosis undergoing in vitro fertilization, Fertil Steril, vol.86, pp.1616-1636, 2006.

R. Nuñez-calonge, S. Cortés, G. Gonzalez, L. M. Kireev, R. Vara et al., Oxidative stress in follicular fluid of young women with low response compared with fertile oocyte donors, Reprod Biomed Online, vol.32, pp.446-56, 2016.

M. E. Hammadeh, C. Fischer-hammadeh, G. T. Rosenbaum, P. Schmidt, and W. , Comparison between cytokine concentration in follicular fluid of poor and high responder patients and their influence of ICSI-outcome, Am J Reprod Immunol, vol.50, pp.131-137, 2003.

L. Scotti, F. Parborell, G. Irusta, D. Zuñiga, I. Bisioli et al., Plateletderived growth factor BB and DD and angiopoietin1 are altered in follicular fluid from polycystic ovary syndrome patients, Mol Reprod Dev, vol.81, pp.748-56, 2014.

L. S. Sleer and C. C. Taylor, Cell-type localization of platelet-derived growth factors and receptors in the postnatal rat ovary and follicle, Biol Reprod, vol.76, pp.379-90, 2007.

J. Andrae, R. Gallini, and C. Betsholtz, Role of platelet-derived growth factors in physiology and medicine, Genes Dev, vol.22, pp.1276-312, 2008.

N. Pascuali, L. Scotti, D. Abramovich, G. Irusta, D. Pietro et al., Inhibition of platelet-derived growth factor (PDGF) receptor affects follicular development and ovarian proliferation, apoptosis and angiogenesis in prepubertal eCG-treated rats, Mol Cell Endocrinol, vol.412, pp.148-58, 2015.

H. Pinkas, B. Fisch, G. Rozansky, C. Felz, G. Kessler-icekson et al., Plateletderived growth factors (PDGF-A and -B) and their receptors in human fetal and adult ovaries, Mol Hum Reprod, vol.14, pp.199-206, 2008.

A. Gougeon, Régulation de l'initiation de la croissance folliculaire, Gynecol Obstet Fertil, vol.39, pp.511-514, 2011.

A. Hasegawa, K. Kumamoto, N. Mochid, S. Komori, and K. Koyama, Gene expression profile during ovarian folliculogenesis, J Reprod Immunol, vol.83, pp.40-44, 2009.

R. Cabezas, N. E. Vega-vela, J. González-sanmiguel, J. González, P. Esquinas et al., PDGF-BB preserves mitochondrial morphology attenuates ROS production and upregulates neuroglobin in an astrocytic model under rotenone insult, Mol Neurobiol, vol.55, pp.3085-95, 2018.

M. C. Carbone, C. Tatone, S. Delle-monache, M. R. Caserta, D. Colonna et al., Antioxidant enzymatic defences in human follicular fluid: characterization and age-dependent changes, Mol Hum Reprod, vol.9, pp.639-682, 2003.

S. E. Elizur, O. Lebovitz, R. Orvieto, J. Dor, and T. Zan-bar, Reactive oxygen species in follicular fluid may serve as biochemical markers to determine ovarian aging and follicular metabolic age, Gynecol Endocrinol, vol.30, pp.705-712, 2014.

A. Ben-meir, K. Kim, R. Mcquaid, N. Esfandiari, Y. Bentov et al., Co-Enzyme Q10 supplementation rescues cumulus cells dysfunction in a maternal aging model, Antioxydants, vol.8, 2019.