Skip to Main content Skip to Navigation
Journal articles

Host-Range Shif between Emerging P[8]-4 Rotavirus and Common P[8] and P[4] Strains

Abstract : In Tunisia, we observed that rotavirus P[8]-3 and P[4] in young children with gastroenteritis associate with the secretor histo-blood-group phenotype. Inversely, the emerging P[8]-4, representing 10% of cases, was exclusively found among nonsecretor patients. Unlike VP8* from P[8]-3 and P[4] strains, the P[8]-4 VP8* protein attached to glycans from saliva samples regardless of the donors Secretor status. Interestingly, a high frequency of FUT2 enzyme deficiency (nonsecretor phenotype) was observed in the population. This may allow co-circulation of P[8]-3 and P[8]-4 strains in secretor and nonsecretor children, respectively.
Document type :
Journal articles
Complete list of metadata

Cited literature [19 references]  Display  Hide  Download
Contributor : Elizabeth Bernardo Connect in order to contact the contributor
Submitted on : Friday, March 20, 2020 - 10:01:36 AM
Last modification on : Wednesday, April 27, 2022 - 4:02:03 AM
Long-term archiving on: : Sunday, June 21, 2020 - 1:14:33 PM


 Restricted access
To satisfy the distribution rights of the publisher, the document is embargoed until : jamais

Please log in to resquest access to the document



Amira Khachou, Béatrice Le Moullac-Vaidye, Cécile Peltier, Adrien Breiman, Berthe-Marie Imbert-Marcille, et al.. Host-Range Shif between Emerging P[8]-4 Rotavirus and Common P[8] and P[4] Strains. ACS Infectious Diseases, American Chemical Society, In press, pp.jiaa122. ⟨10.1093/infdis/jiaa122/5809929⟩. ⟨inserm-02512938⟩



Record views