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Host-Range Shif between Emerging P[8]-4 Rotavirus and Common P[8] and P[4] Strains

Abstract : In Tunisia, we observed that rotavirus P[8]-3 and P[4] in young children with gastroenteritis associate with the secretor histo-blood-group phenotype. Inversely, the emerging P[8]-4, representing 10% of cases, was exclusively found among nonsecretor patients. Unlike VP8* from P[8]-3 and P[4] strains, the P[8]-4 VP8* protein attached to glycans from saliva samples regardless of the donors Secretor status. Interestingly, a high frequency of FUT2 enzyme deficiency (nonsecretor phenotype) was observed in the population. This may allow co-circulation of P[8]-3 and P[8]-4 strains in secretor and nonsecretor children, respectively.
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Amira Khachou, Béatrice Le Moullac-Vaidye, Cécile Peltier, Adrien Breiman, Berthe-Marie Imbert-Marcille, et al.. Host-Range Shif between Emerging P[8]-4 Rotavirus and Common P[8] and P[4] Strains. ACS Infectious Diseases, American Chemical Society, In press, pp.jiaa122. ⟨10.1093/infdis/jiaa122/5809929⟩. ⟨inserm-02512938⟩

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