Skin-specific antibodies neutralizing mycolactone toxin during the spontaneous healing of Mycobacterium ulcerans infection - Archive ouverte HAL Access content directly
Journal Articles Science Advances Year : 2020

Skin-specific antibodies neutralizing mycolactone toxin during the spontaneous healing of Mycobacterium ulcerans infection

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Mélanie Foulon
  • Function : Author
Amélie Pouchin
  • Function : Author
Jeremy Manry
  • Function : Author
  • PersonId : 911182
Fida Khater
Marie Robbe-Saule
Amandine Durand
  • Function : Author
Lucille Esnault
Laurent Abel
Estelle Marion
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Abstract

Buruli ulcer, a neglected tropical infectious disease, is caused by Mycobacterium ulcerans. Without treatment, its lesions can progress to chronic skin ulcers, but spontaneous healing is observed in 5% of cases, suggesting the possible establishment of a host strategy counteracting the effects of M. ulcerans. We reveal here a skin-specific local humoral signature of the spontaneous healing process, associated with a rise in antibody-producing cells and specific recognition of mycolactone by the mouse IgG2a immunoglobulin subclass. We demonstrate the production of skin-specific antibodies neutralizing the immunomodulatory activity of the mycolactone toxin, and confirm the role of human host machinery in triggering effective local immune responses by the detection of anti-mycolactone antibodies in patients with Buruli ulcer. Our findings pave the way for substantial advances in both the diagnosis and treatment of Buruli ulcer in accordance with the most recent challenges issued by the World Health Organization.
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inserm-02512893 , version 1 (20-03-2020)

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Mélanie Foulon, Amélie Pouchin, Jeremy Manry, Fida Khater, Marie Robbe-Saule, et al.. Skin-specific antibodies neutralizing mycolactone toxin during the spontaneous healing of Mycobacterium ulcerans infection. Science Advances , 2020, 6 (9), pp.eaax7781. ⟨10.1126/sciadv.aax7781⟩. ⟨inserm-02512893⟩
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