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PERSPECTIVES ON THE USE OF SUPER-ENHANCERS AS A DEFINING FEATURE OF CELL/TISSUE- IDENTITY GENES

Abstract : Super-enhancers (SE) have become a popular concept and are widely used as a feature defining key identity genes. Here, we provide perspectives on the use of SE to define and identify cell/tissue-identity genes. By mining SE and their associated genes using murine functional genomics data, we highlight and discuss current limitations and open questions regarding both the sensitivity and specificity of identity genes/TFs predicted by SE. In this context, we point to cell/tissue-specific promoters as an important additional level of information, which we propose to combine with SE when aiming to define potential identity genes.
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https://www.hal.inserm.fr/inserm-02506724
Contributor : Marie-Hélène Derudas <>
Submitted on : Thursday, March 12, 2020 - 3:02:12 PM
Last modification on : Friday, March 13, 2020 - 1:18:12 AM
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  • HAL Id : inserm-02506724, version 1

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Julie Dubois-Chevalier, Vanessa Dubois, Bart Staels, Philippe Lefebvre, Jérôme Eeckhoute. PERSPECTIVES ON THE USE OF SUPER-ENHANCERS AS A DEFINING FEATURE OF CELL/TISSUE- IDENTITY GENES. Epigenomics, Future Medicine, In press, Epub Ahead of Print. ⟨inserm-02506724⟩

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