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Journal articles
The intellectual disability protein Oligophrenin1 controls astrocyte morphology and migration: Structural and migratory alterations in astrocytes deficient for OPHN1 via the ROCK pathway
Abstract : Astrocytes are involved in several aspects of neuronal development and properties which are altered in intellectual disability (ID). Oligophrenin-1 is a RhoGAP protein implicated in actin cytoskeleton regulation, and whose mutations are associated with X-linked ID. Oligophrenin-1 is expressed in neurons, where its functions have been widely reported at the synapse, as well as in glial cells. However, its roles in astrocytes are still largely unexplored. Using in vitro and in vivo models of oligophrenin1 disruption in astrocytes, we found that oligophrenin1 regulates at the molecular level the RhoA/ROCK/MLC2 pathway in astroglial cells. We also showed at the cellular level that oligophrenin1 modulates astrocyte morphology and migration both in vitro and in vivo, and is involved in glial scar formation. Altogether, these data suggest that oligophrenin1 deficiency alters not only neuronal but also astrocytic functions, which might contribute to the development of ID.
Cited literature [87 references]
https://www.hal.inserm.fr/inserm-02506646
Contributor : Clara Martinez Rico Connect in order to contact the contributor
Submitted on : Thursday, March 12, 2020 - 2:23:05 PM
Last modification on : Friday, March 18, 2022 - 3:38:21 AM
Long-term archiving on: : Saturday, June 13, 2020 - 3:27:03 PM
Contributor : Clara Martinez Rico Connect in order to contact the contributor
Submitted on : Thursday, March 12, 2020 - 2:23:05 PM
Last modification on : Friday, March 18, 2022 - 3:38:21 AM
Long-term archiving on: : Saturday, June 13, 2020 - 3:27:03 PM
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PB_Pillet_et_al_Glia2020.pdf
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