Skip to Main content Skip to Navigation
Journal articles

Nucleotide lipid-based hydrogel as a new biomaterial ink for biofabrication

Abstract : One of the greatest challenges in the field of biofabrication remains the discovery of suitable bioinks that satisfy physicochemical and biological requirements. Despite recent advances in tissue engineering and biofabrication, progress has been limited to the development of technologies using polymer-based materials. Here, we show that a nucleotide lipid-based hydrogel resulting from the self-assembly of nucleotide lipids can be used as a bioink for soft tissue reconstruction using injection or extrusion-based systems. To the best of our knowledge, the use of a low molecular weight hydrogel as an alternative to polymeric bioinks is a novel concept in biofabrication and 3D bioprinting. Rheological studies revealed that nucleotide lipid-based hydrogels exhibit suitable mechanical properties for biofabrication and 3D bioprinting, including i) fast gelation kinetics in a cell culture medium and ii) shear moduli and thixotropy compatible with extruded oral cell survival (human gingival fibroblasts and stem cells from the apical papilla). This polymer-free soft material is a promising candidate for a new bioink design.
Complete list of metadata

Cited literature [54 references]  Display  Hide  Download
Contributor : Myriam Bodescot Connect in order to contact the contributor
Submitted on : Thursday, March 5, 2020 - 2:35:28 PM
Last modification on : Monday, April 25, 2022 - 9:21:35 AM


Publication funded by an institution




Bérangère Dessane, Rawen Smirani, Guillaume Bouguéon, Tina Kauss, Emeline Ribot, et al.. Nucleotide lipid-based hydrogel as a new biomaterial ink for biofabrication. Scientific Reports, Nature Publishing Group, 2020, 10 (1), pp.2850. ⟨10.1038/s41598-020-59632-w⟩. ⟨inserm-02499702⟩



Record views


Files downloads