, CME

, A00013-38); German centres: Ethik-Kommission der Bayerischen Landesarztekammer (N° 10015); Reykjavik: National Biotecs Committe of Iceland (NBCI) (N° VSNb2011090016/03.11); Pavia: Fondazione IRCCS Policlinico 'San Matteo' (N° P-20110024215); Turin: Comitato Etico dell' Azienda Sanitaria Locale TO/2 di Torino (N° 569/09/08); Verona: Comitato Etico per la Sperimentazione dell' Azienda Ospedaliera Istituti Ospitalieri di Verona (N° 1393), pp.209-226, 2011.

, Barcelona: Comité Ético de Investigación Clínica del Instituto Municipal de Asistencia Sanitaria

, Huelva: Comisión de Investigación del Hospital Juan Ramón Jiménez de Huelva, 20090417.

, UK centres: NRES Committee London -Stanmore (REC Reference 11/LO/0965 IRAS number 70769)] and in SAPALDIA [Swiss Academy of Medical Sciences and the regional committees for each study centre; ethics approval is coordinated by the lead ethical agency EKNZ in, Basel: Swiss Academy of Medical Sciences and the ethics committee of Basel (N° PV123/00

R. Lozano, Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study, Lancet, vol.380, pp.2095-2128, 2010.
URL : https://hal.archives-ouvertes.fr/hal-00827612

, Global Initiative for Chronic Obstructive Lung Disease. Global Strategy for the Diagnosis, Management, and Prevention of Chronic Obstructive Pulmonary Disease, National Institutes of Health Publication No, 2018.

C. D. Mathers and D. Loncar, Projections of global mortality and burden of disease from 2002 to 2030, PLoS Med, vol.3, 2006.

T. R. Schermer, Current clinical guideline definitions of airflow obstruction and COPD overdiagnosis in primary care, Eur. Respir. J, vol.32, pp.945-952, 2008.

S. Sawalha, L. Hedman, E. Rönmark, B. Lundbäck, and A. Lindberg, Pre-and post-bronchodilator airway obstruction are associated with similar clinical characteristics but different prognosis -report from a population-based study, Int. J. Chron. Obstruct. Pulmon. Dis, vol.12, pp.1269-1277, 2017.

J. Gibson, R. Loddenkemper, Y. Sibille, and B. Lundbäck, Tobacco smoking in The European Lung White Book, pp.98-111, 2013.

S. K. Lhachimi, DYNAMO-HIA-a Dynamic Modeling tool for generic Health Impact Assessments, PLoS One, vol.7, 2012.

P. G. Burney, C. Luczynska, S. Chinn, and D. Jarvis, The European Community Respiratory Health Survey, Eur. Respir. J, vol.7, pp.954-960, 1994.

, European Community Respiratory Health Survey II Steering Committee. The European Community Respiratory Health Survey II, Eur. Respir. J, vol.20, pp.1071-1079, 2002.

A. F. Amaral, Changes in IgE sensitization and total IgE levels over 20 years of follow-up, J. Allergy Clin. Immunol, vol.137, pp.1788-1795, 2016.
URL : https://hal.archives-ouvertes.fr/hal-01886136

U. Ackermann-liebrich, Lung function and long term exposure to air pollutants in Switzerland. Study on Air Pollution and Lung Diseases in Adults (SAPALDIA) Team, Am. J. Respir. Crit. Care Med, vol.155, pp.122-129, 1997.

U. Ackermann-liebrich, Follow-up of the Swiss Cohort Study on Air Pollution and Lung Diseases in Adults (SAPALDIA 2) 1991-2003: methods and characterization of participants, Soz. Praventivmed, vol.50, pp.245-263, 2005.

S. Hansen, Gender differences in adult-onset asthma: results from the Swiss SAPALDIA cohort study, Eur. Respir. J, vol.46, pp.1011-1020, 2015.

R. De-marco, Incidence of chronic obstructive pulmonary disease in a cohort of young adults according to the presence of chronic cough and phlegm, Am. J. Respir. Crit. Care Med, vol.175, pp.32-39, 2007.

N. Terzikhan, Prevalence and incidence of COPD in smokers and non-smokers: the Rotterdam Study, Eur. J. Epidemiol, vol.31, pp.785-792, 2016.

R. De-marco, An international survey of chronic obstructive pulmonary disease in young adults according to GOLD stages, Thorax, vol.59, pp.120-125, 2004.

N. Mercado, K. Ito, and P. J. Barnes, Accelerated ageing of the lung in COPD: new concepts, Thorax, vol.70, pp.482-489, 2015.

M. K. Han, Gender and chronic obstructive pulmonary disease: why it matters, Am. J. Respir. Crit. Care Med, vol.176, pp.1179-1184, 2007.

A. Tam, Sex-related differences in pulmonary function following 6 months of cigarette exposure: implications for sexual dimorphism in mild COPD, PLoS One, vol.11, 2016.

A. F. Amaral, D. P. Strachan, P. G. Burney, and D. L. Jarvis, Female smokers are at greater risk of airflow obstruction than male smokers. UK Biobank, Am. J. Respir. Crit. Care Med, vol.195, pp.1226-1235, 2017.

I. C. Sørheim, Gender differences in COPD: are women more susceptible to smoking effects than men?, Thorax, vol.65, pp.480-485, 2010.

A. Marcon, Trends in smoking initiation in Europe over 40 years: A retrospective cohort study, PLoS One, vol.13, 2018.

G. Pesce, Time and age trends in smoking cessation in Europe, PLoS One, vol.14, 2019.

W. C. Tan, Characteristics of COPD in never-smokers and ever-smokers in the general population: Results from the CanCOLD study, Thorax, vol.70, pp.822-829, 2015.

B. Lamprecht, COPD in never smokers: results from the population-based burden of obstructive lung disease study, Chest, vol.139, pp.752-763, 2011.

O. Savran and C. S. Ulrik, Early life insults as determinants of chronic obstructive pulmonary disease in adult life, Int. J. Chron. Obstruct. Pulmon. Dis, vol.13, pp.683-693, 2018.

S. Hagstad, Prevalence and risk factors of COPD among never-smokers in two areas of Sweden -Occupational exposure to gas, dust or fumes is an important risk factor, Respir. Med, vol.109, pp.1439-1445, 2015.

N. A. Assad, J. Balmes, S. Mehta, U. Cheema, and A. Sood, Chronic obstructive pulmonary disease secondary to household air pollution, Semin. Respir. Crit. Care Med, vol.36, pp.408-421, 2015.

Z. J. Andersen, Chronic obstructive pulmonary disease and long-term exposure to traffic-related air pollution: a cohort study, Am. J. Respir. Crit. Care Med, vol.183, pp.455-461, 2011.

S. S. Salvi and P. J. Barnes, Chronic obstructive pulmonary disease in non-smokers, Lancet, vol.374, pp.733-743, 2009.

J. K. Stoller and L. S. Aboussouan, Alpha1-antitrypsin deficiency, Lancet, vol.365, pp.2225-2236, 2005.

R. De-marco, Long-term outcomes in mild/moderate chronic obstructive pulmonary disease in the European Community Respiratory Health Survey, Am. J. Respir. Crit. Care Med, vol.180, pp.956-963, 2009.

P. Rogliani, J. Ora, E. Puxeddu, and M. Cazzola, Airflow obstruction: is it asthma or is it COPD?, Int. J. Chron. Obstruct. Pulmon. Dis, vol.11, pp.3007-3013, 2016.

M. R. Sears, Smoking, asthma, chronic airflow obstruction and COPD, Eur. Respir. J, vol.45, pp.586-588, 2015.

J. Roca, References values for forced spirometry, Eur. Respir. J, vol.11, pp.1354-1362, 1998.

M. P. Swanney, Using the lower limit of normal for the FEV1/FVC ratio reduces the misclassification of airway obstruction, Thorax, vol.63, pp.1046-1051, 2008.

T. R. Schermer, Should the diagnosis of COPD be based on a single spirometry test?, NPJ Prim. Care Respir. Med, vol.26, p.16059, 2016.

S. D. Aaron, Diagnostic instability and reversals of chronic obstructive pulmonary disease diagnosis in individuals with mild to moderate airflow obstruction, Am. J. Respir. Crit. Care Med, vol.196, pp.306-314, 2017.

B. W. Martin, SAPALDIA: methods and participation in the cross-sectional part of the Swiss Study on Air Pollution and Lung Diseases in Adults, Soz. Praventivmed, vol.42, pp.67-84, 1997.

M. R. Miller, Standardisation of spirometry, Eur. Respir. J, vol.26, pp.319-338, 2005.

P. O. Bridevaux, Spirometer replacement and serial lung function measurements in population studies: results from the SAPALDIA study, Am. J. Epidemiol, vol.181, pp.752-761, 2015.

R. J. Knudson, M. D. Lebowitz, C. J. Holberg, and B. Burrows, Changes in the normal maximal expiratory flow-volume curve with growth and aging, Am. Rev. Respir. Dis, vol.127, pp.725-734, 1983.

I. Cerveri, Underestimation of airflow obstruction among young adults using FEV1/FVC <70% as a fixed cut-off: a longitudinal evaluation of clinical and functional outcomes, Thorax, vol.63, pp.1040-1045, 2008.