An overview of targeted alpha therapy, Tumor Biol, vol.33, p.573, 2012. ,
Towards translation of 212Pb as a clinical therapeutic; getting the lead in!, Dalton Trans, vol.40, p.6068, 2011. ,
Possible production of radioactive isotopes of element 85, Phys Rev, vol.57, p.1087, 1940. ,
The present status of elements 85 and 87, J Phys Chem, vol.58, p.21, 1954. ,
Gmelin Handbook of Inorganic Chemistry: At, Astatine, 1985. ,
Microdosimetry of astatine-211 single-cell irradiation: Role of daughter polonium-211 diffusion, Med Phys, vol.31, p.218, 2004. ,
Measuring astatine-211 distributions with SPECT, Phys Med Biol, vol.38, p.1121, 1993. ,
Excitation function for the 209-Bi(7-Li,5n)211-Rn nuclear reaction as a route to the 211-Rn-211-At generator, J Label Compd Radiopharm, vol.28, p.233, 1981. ,
Fusion of 9 Li with 208 Pb, Phys Rev C, vol.80, p.54609, 2009. ,
Polonium-210 as a poison, J Radiol Prot, vol.27, p.17, 2007. ,
Astatine-211: Production and availability, Current Radiopharm, vol.4, p.177, 2011. ,
Experimental study of the cross-sections of [alpha]-particle induced reactions on 209 Bi, Appl Radiat Isot, vol.63, p.1, 2005. ,
Dry-distillation of astatine-211 from irradiated bismuth targets: A time-saving procedure with high recovery yields, Appl Radiat Isot, vol.55, p.157, 2001. ,
Wet harvesting of nocarrier-added 211 At from an irradiated 209 Bi target for radiopharmaceutical applications, J Radioanal Nucl Chem, vol.262, p.593, 2005. ,
Extraction of astatine-211 in diisopropylether (DIPE), Radiochim Acta, vol.97, p.161, 2009. ,
URL : https://hal.archives-ouvertes.fr/in2p3-00382729
Feasibility of the radioastatination of a monoclonal antibody with astatine-211 purified by wet extraction, J Label Compd Radiopharm, vol.51, p.379, 2008. ,
High-level production of alpha-particle-emitting (211)At and preparation of (211)At-labeled antibodies for clinical use, J Nucl Med, vol.42, p.1508, 2001. ,
Observation of astatine compounds by time-of-flight mass spectrometry, Inorg Chem, vol.5, p.766, 1966. ,
Chemical properties of astatine. I, J Chem Phys, vol.17, p.1, 1949. ,
The oxidation states of astatine in aqueous solution, J Am Chem Soc, vol.83, p.805, 1961. ,
Inorganic astatine chemistry: Formation of complexes of astatine, Radiochim Acta, vol.33, p.145, 1983. ,
Inorganic astatine chemistry part II: The chameleon behaviour and electrophilicity of At-species, Radiochim Acta, vol.47, p.97, 1989. ,
Investigation of the movement of astatine in an electric field, Radiochem Radioanal Lett, vol.35, p.257, 1978. ,
Cations of astatine in water: illustration and properties, Radiochem Radioanal Lett, vol.36, p.389, 1978. ,
Studies of polyhalogenide ions of astatine, Radiochem Radioanal Lett, vol.54, p.165, 1982. ,
The Radiochemistry of Astatine. DOE sponsored Nuclear Science Series monogram ,
, Available at www .ntis.gov/search/product.aspx?, ABBR = DE88015386 Accessed on, 1988.
Formation and stability of astatide-mercury complexes, J Radioanal Nucl Chem, vol.268, p.91, 2006. ,
Preparation of Rh[16aneS4-diol] 211 At and Ir[16aneS4-diol] 211 At complexes as potential precursors for astatine radiopharmaceuticals. Part I: Synthesis, Bioconjug Chem, vol.19, p.958, 2008. ,
Solvent extraction studies of interhalogen compounds of astatine, J Phys Chem, vol.65, p.325, 1961. ,
Pseudohalogen compounds of astatine: Synthesis and characterization of At/I/-tricyanomethanide-and At/I/-azide-compounds, J Radioanal Nucl Chem, vol.117, p.275, 1987. ,
Synthesis and characterization of cationic astatine compounds with sulphurcontaining ligands stable in aqueous solutions, J Radioanal Nucl Chem, vol.96, p.333, 1985. ,
Synthesis and first characterization of cationic At/I/-compounds with selenium-containing neutral ligands, J Radioanal Nucl Chem, vol.119, p.181, 1987. ,
First investigation of complex formation of At(I) with phosphorous organic compounds, Radiochim Acta, vol.47, p.129, 1989. ,
The EDTA complexes of astatine, J Radioanal Nucl Chem, vol.127, p.193, 1988. ,
Characterization of DTPA complexes and conjugated antibodies of astatine, J Radioanal Nucl Chem, vol.137, p.365, 1989. ,
Nitrilotriacetate complex of univalent astatine, Radiochim Acta, vol.56, p.173, 1992. ,
Preparation and preliminary evaluation of astatine-211 labeled IgG via DTPA anhydride, J Radioanal Nucl Chem, vol.227, p.187, 1998. ,
Complex formation equilibria between astatine(I) and sulphur-containing chelating ligands, Polyhedron, vol.10, p.11, 1991. ,
Synthesis and biodistribution study of a new 211-At-calix[4]arene complex, J Label Compd Radiopharm, vol.43, p.1219, 2000. ,
Determination of stability constants between complexing agents and At(I) and At(III) species present at ultra-trace concentrations, Inorg Chim Acta, vol.362, p.2654, 2009. ,
URL : https://hal.archives-ouvertes.fr/in2p3-00382733
, The halogens: Fluorine, Chlorine, Bromine, Iodine and Astatine, vol.789, 1997.
Alpha-particle-induced radiolytic effects on the chemical behavior of (211)At, J Nucl Med, vol.3, p.1190, 2007. ,
Recent Advances in the Organic Chemistry of Astatine. In: PATAI'S Chemistry of Functional Groups, John Wiley and Sons, 2009. ,
Stö cklin G. No-carrier added radiohalogenation methods with heavy halogens, Radiochim Acta, vol.34, p.47, 1983. ,
Halogen exchanges using crown ethers: Synthesis and preliminary biodistribution of 6-[ 211 At]astatomethyl-19-norcholest-5(10)-en-3 beta-ol, Int J Appl Radiat Isot, vol.36, p.561, 1985. ,
Potential diagnostic and therapeutic agents for malignant melanoma: Synthesis of heavy radiohalogenated derivatives of methylene blue by electrophilic and nucleophilic methods, J Radioanal Nucl Chem Lett, vol.107, p.337, 1986. ,
Synthesis and analysis of 2-[ 211 At]-l-phenylalanine and 4-[ 211 At]-lphenylalanine and their uptake in human glioma cell cultures in-vitro, Appl Radiat Isot, vol.68, p.1060, 2010. ,
The reaction of astatine with aromatic diazonium compounds, Radiochem Radioanal Lett, vol.51, p.135, 1982. ,
Reaction of aromatic diazonium salts with carrier-free radioiodine and astatine. Evidence for complex formation, J Am Chem Soc, vol.101, p.3121, 1979. ,
A simple method for labelling proteins with 211 At via diazotized aromatic diamine, J Radioanal Nucl Chem Lett, vol.117, p.197, 1987. ,
The preparation of astatine labelled tyrosine using an electrophilic reaction, J Radioanal Nucl Chem, vol.94, p.185, 1985. ,
Synthesis of astatine-tagged methylene blue, a compound for fighting micrometastases and individual cells of melanoma, J Radioanal Nucl Chem, vol.237, p.155, 1998. ,
The preparation and stability of astatotyrosine and astato-iodotyrosine, Int J Appl Radiat Isot, vol.30, p.749, 1979. ,
The preparation of aromatic astatine compounds through aromatic mercury compounds part II: Astatination of pyrimidines and steroids, J Label Compd Radiopharm, vol.18, p.799, 1981. ,
A kit method for the high level synthesis of [ 211 At]MABG, Bioorg Med Chem, vol.15, p.3430, 2007. ,
Monoclonal antibody F(ab¢) 2 fragment labeled with N-succinimidyl 2,4-dimethoxy-3-halobenzoates: In vivo comparison of iodinated and astatinated fragments, Nucl Med Biol, vol.21, p.105, 1994. ,
Preparation and preliminary evaluation of 4-[ 211 At]astato-N-piperidinoethyl benzamide, Nucl Med Biol, vol.22, p.467, 1995. ,
5-[ 211 At]Astato-2'-deoxyuridine, an {alpha}-particle-emitting endoradiotherapeutic agent undergoing DNA incorporation, Cancer Res, vol.56, p.1204, 1996. ,
No-carrier added astatination of N-succinimidyl-3-(tri-n-butylstannyl) benzoate (ATE) via electrophilic destannylation, Radiochim Acta, vol.47, p.131, 1989. ,
The medicinal chemistry of carboranes, Coord Chem Rev, vol.232, p.173, 2002. ,
Reagents for astatination of biomolecules: Comparison of the in vivo distribution and stability of some radioiodinated/astatinated benzamidyl and nido-carboranyl compounds, Bioconjug Chem, vol.15, p.203, 2004. ,
At]Astatine-labeled compound stability: Issues with released [ 211 At]astatide and development of labeling reagents to increase stability, Current Radiopharm, vol.1, p.144, 2008. ,
Blocking [ 211 At]astatide accumulation in normal tissues: Preliminary evaluation of seven potential compounds, Nucl Med Biol, vol.25, p.351, 1998. ,
Destructive action of astatine 211 (element 85) on the thyroid gland of the rat, Proc Soc Exp Biol Med, vol.73, p.51, 1950. ,
The induction of tumors in the rat by astatine-211, Radiat Res, vol.9, p.378, 1958. ,
,
Radiotoxicity of systematically administered [ 211 At]astatide in B6C3F1 and BALB/c (nu/nu) mice: A long-term survival study with histologic analysis, Int J Radiat Oncol Biol Phys, vol.35, p.69, 1996. ,
Targeted alpha-particle radiotherapy with 211 At-labeled monoclonal antibodies, Nucl Med Biol, vol.34, p.779, 2007. ,
The preparation of astatine labelled proteins, Int J Appl Radiat Isot, vol.26, p.25, 1975. ,
The preparation of astatine labelled proteins using an electrophilic reaction, Int J Nucl Med Biol, vol.5, p.229, 1978. ,
The preparation of astatotyrosine, Int J Appl Radiat Isot, vol.28, p.595, 1977. ,
The preparation and stability of 211 At-astato-imidazoles, Int J Appl Radiat Isot, vol.31, p.275, 1980. ,
The nature of the astatine-protein bond, Int J Appl Radiat Isot, vol.32, p.905, 1981. ,
Preparation of a biologically stable and immunogenically competent astatinated protein, Int J Nucl Med Biol, vol.4, p.219, 1977. ,
Astatination of proteins using an N-succinimidyl tri-n-butylstannyl benzoate intermediate, Int J Rad Appl Instrum A, vol.39, p.227, 1988. ,
Radiopharmaceutical chemistry of targeted radiotherapeutics, part 1: Effects of solvent on the degradation of radiohalogenation precursors by 211 At alpha-particles, J Nucl Med, vol.46, p.700, 2005. ,
Clinical experience with alpha-particle emitting 211 At: Treatment of recurrent brain tumor patients with 211 At-labeled chimeric antitenascin monoclonal antibody 81C6, J Nucl Med, vol.49, p.30, 2008. ,
Astatine-211 labeling of internalizing anti-EGFRvIII monoclonal antibody using Nsuccinimidyl 5-[ 211 At]astato-3-pyridinecarboxylate, Nucl Med Biol, vol.26, p.405, 1999. ,
N-succinimidyl 3-[ 211 At]astato-4-guanidinomethylbenzoate: An acylation agent for labeling internalizing antibodies with alpha-particle emitting 211 At, Nucl Med Biol, vol.30, p.351, 2003. ,
Astatine-211 labeling of an antimelanoma antibody and its Fab fragment using N-succinimidyl p-astatobenzoate: Comparisons in vivo with the p-[ 125 I]iodobenzoyl conjugate, Bioconjug Chem, vol.2, p.171, 1991. ,
Comparative tissue distribution in mice of the alpha-emitter 211 At and 131 I as labels of a monoclonal antibody and F(ab¢) 2 fragment, Cancer Res, vol.50, p.3514, 1990. ,
Preparation and in vivo evaluation of novel linkers for 211 At labeling of proteins, Nucl Med Biol, vol.31, p.1061, 2004. ,
Preparation and in vivo evaluation of a novel stabilized linker for 211 At labeling of protein, Nucl Med Biol, vol.33, p.469, 2006. ,
Preparation and in vivo evaluation of linkers for 211 At labeling of humanized anti-Tac, Nucl Med Biol, vol.28, p.845, 2001. ,
Reagents for astatination of biomolecules. 2. Conjugation of anionic boron cage pendant groups to a protein provides a method for direct labeling that is stable to in vivo deastatination, Bioconjug Chem, vol.18, p.1226, 2007. ,
Preparation and in vivo evaluation of radioiodinated closo-decaborate(2-) derivatives to identify structural components that provide low retention in tissues, Nucl Med Biol, vol.37, p.167, 2010. ,
Reagents for astatination of biomolecules. 5. Evaluation of hydrazone linkers in 211 At-and 125 I-labeled closo-decaborate(2-) conjugates of fab¢ as a means of decreasing kidney retention, Bioconjug Chem, vol.22, p.1089, 2011. ,
Radioiodination and astatination of octreotide by conjugation labeling, Nucl Med Biol, vol.27, p.329, 2000. ,
Radioiodine and 211 At-labeled guanidinomethyl halobenzoyl octreotate conjugates: Potential peptide radiotherapeutics for somatostatin receptor-positive cancers, Peptides, vol.25, p.2087, 2004. ,
Synthesis and evaluation of glycosylated octreotate analogues labeled with radioiodine and 211 At via a tin precursor, Bioconjug Chem, vol.17, p.195, 2006. ,
Avidinbiotin technology in targeted therapy, Expert Opin Drug Deliv, vol.7, p.551, 2010. ,
Preparation and biological evaluation of an astatine-211 labeled biotin conjugate: Biotinyl-3-[ 211 At]astatoanilide, Nucl Med Biol, vol.24, p.135, 1997. ,
Astatine-211-labeled biotin conjugates resistant to biotinidase for use in pretargeted radioimmunotherapy, Nucl Med Biol, vol.25, p.81, 1998. ,
Biotin reagents in antibody pretargeting. 6. Synthesis and in vivo evaluation of astatinated and radioiodinated aryl-and nidocarboranyl-biotin derivatives, Bioconjug Chem, vol.15, p.601, 2004. ,
Reagents for astatination of biomolecules. 3. Comparison of closodecaborate(2-) and closo-dodecaborate(2-) moieties as reactive groups for labeling with astatine-211, Bioconjug Chem, vol.20, p.591, 2009. ,
Synthesis and biodistribution of 211 At-labeled, biotinylated, and charge-modified poly-L-lysine: Evaluation for use as an effector molecule in pretargeted intraperitoneal tumor therapy, Bioconjug Chem, vol.13, p.502, 2002. ,
At-labeled and biotinylated effector molecules for pretargeted radioimmunotherapy using poly-L-and poly-D-lysine as multicarriers, Clin Cancer Res, vol.9, issue.211, p.3873, 2003. ,
In vivo distribution of avidin-conjugated MX35 and 211 At-labeled, biotinylated poly-L-lysine for pretargeted intraperitoneal a-radioimmunotherapy, Cancer Biother Radiopharm, vol.26, p.727, 2011. ,
211 At-and 131 Ilabeled bisphosphonates with high in vivo stability and bone accumulation, J Nucl Med, vol.40, p.1197, 1999. ,
1-(m-[ 211 At]astatobenzyl)guanidine: Synthesis via astato demetalation and preliminary in vitro and in vivo evaluation, Bioconjug Chem, vol.3, p.499, 1992. ,
211-At-labelling of polymer particles for radiotherapy: Synthesis, purification and stability, J Label Compd Radiopharm, vol.33, p.977, 1993. ,
Alpha-particle radiotherapy with 211 At-labeled monodisperse polymer particles, 211 At-labeled IgG proteins, and free 211 At in a murine intraperitoneal tumor model, Gynecol Oncol, vol.57, p.9, 1995. ,
Astatination of nanoparticles containing silver as possible carriers of 211 At, Appl Radiat Isot, vol.64, p.201, 2006. ,
211 AtCl@US-tube nanocapsules: A new concept in radiotherapeuticagent design, Small, vol.3, p.1496, 2007. ,
The cytotoxicity and microdosimetry of astatine-211-labeled chimeric monoclonal antibodies in human glioma and melanoma cells in vitro, Radiat Res, vol.149, p.155, 1998. ,
, , p.211
, At-labeled trastuzumab in human breast cancer cell lines: Effect of specific activity and HER2 receptor heterogeneity on survival fraction, Nucl Med Biol, vol.33, p.333, 2006.
Radiation doses to non-Hodgkin's lymphoma cells and normal bone marrow exposed in vitro. Comparison of an alpha-emitting radioimmunoconjugate and external gamma-irradiation ,
, Int J Radiat Biol, vol.78, p.133, 2002.
, , p.211
, At-anti-CD33 antibody therapy of leukaemia cells overcomes cellular resistance seen in vivo against gemtuzumab ozogamicin, Eur J Nucl Med Mol Imaging, vol.37, p.851, 2010.
Effect of cetuximab in combination with alpha-radioimmunotherapy in cultured squamous cell carcinomas, Nucl Med Biol, vol.38, p.103, 2011. ,
Targeting against epidermal growth factor receptors. Cellular processing of astatinated EGF after binding to cultured carcinoma cells, Anticancer Res, vol.24, p.4035, 2004. ,
Relative biological effectiveness of the alpha-particle emitter (211)At for double-strand break induction in human fibroblasts, Radiat Res, vol.167, p.312, 2007. ,
RBE of a-particles from 211 At for complex DNA damage and cell survival in relation to cell cycle position, Int J Rad Biol, vol.87, p.372, 2011. ,
The anti-CD25 monoclonal antibody 7G7/B6, armed with the a-emitter 211 At, provides effective radioimmunotherapy for a murine model of leukemia, Cancer Res, vol.66, p.8227, 2006. ,
Effective treatment of a murine model of adult T-cell leukemia using 211 At-7G7/B6 and its combination with unmodified anti-Tac (daclizumab) directed toward CD25, Blood, vol.108, p.1007, 2006. ,
Effective therapy of murine models of human leukemia and lymphoma with radiolabeled anti-CD30 antibody, HeFi-1, Proc Natl Acad Sci U S A, vol.104, p.8444, 2007. ,
Radioimmunotherapy with astatine-211 using chimeric monoclonal antibody U36 in head and neck squamous cell carcinoma, Laryngoscope, vol.117, p.1013, 2007. ,
Effective treatment of established human breast tumor xenografts in immunodeficient mice with a single dose of the a-emitting radioisotope astatine-211 conjugated to anti-HER2/neu diabodies, Clin Cancer Res, vol.14, p.875, 2008. ,
Administered activity and metastatic cure probability during radioimmunotherapy of ovarian cancer in nude mice with 211 At-MX35 F(ab¢) 2, Int J Radiat Oncol Biol Phys, vol.66, p.1228, 2006. ,
{alpha}-radioimmunotherapy of intraperitoneally growing OVCAR-3 tumors of variable dimensions: Outcome related to measured tumor size and mean absorbed dose, J Nucl Med, vol.47, p.1342, 2006. ,
Fractionated radioimmunotherapy of intraperitoneally growing ovarian cancer in nude mice with 211At-MX35 F(ab¢) 2 : Therapeutic efficacy and myelotoxicity, Nucl Med Biol, vol.33, p.1065, 2006. ,
Repeated intraperitoneal a-radioimmunotherapy of ovarian cancer in mice, J Oncol, vol.2010, p.1, 2010. ,
Comparison of therapeutic efficacy and biodistribution of 213 Bi-and 211 Atlabeled monoclonal antibody MX35 in an ovarian cancer model, Nucl Med Biol, vol.39, p.15, 2012. ,
Radioimmunotherapy of neoplastic meningitis in rats using an alpha-particle-emitting immunoconjugate, Cancer Res, vol.54, p.4719, 1994. ,
Tissue distribution and radiation dosimetry of astatine-211-labeled chimeric 81C6, an a-particle-emitting immunoconjugate, Nucl Med Biol, vol.24, p.255, 1997. ,
Therapeutic efficacy of astatine-211-labeled trastuzumab on radioresistant SKOV-3 tumors in nude mice, Int J Radiat Oncol Biol Phys, vol.69, p.572, 2007. ,
Treatment of HER2-positive breast carcinomatous meningitis with intrathecal administration of [alpha]-particle-emitting 211 Atlabeled trastuzumab, Nucl Med Biol, vol.36, p.659, 2009. ,
Intraperitoneal {alpha}-particle radioimmunotherapy of ovarian cancer patients: Pharmacokinetics and dosimetry of 211 At-MX35 F(ab¢) 2 -a phase I study, J Nucl Med, vol.50, p.1153, 2009. ,
A comparison of the metabolism of iodine and of element 85 (eka-iodine), Proc Natl Acad Sci U S A, vol.26, p.483, 1940. ,
Reagents for astatination of biomolecules. 4. Comparison of maleimidocloso-decaborate(2-) and meta-[ 211 At]astatobenzoate conjugates for labeling anti-CD45 antibodies with [ 211 At]astatine, Bioconjug Chem, vol.20, 1983. ,
Radiolabelling of proteins with stabilised hypervalent astatine-211: Feasability and stability, J Nucl Med, vol.52, p.1486, 2011. ,
The ARRONAX project, Current Radiopharm, vol.4, p.186, 2011. ,
,