D. Chen, J. Yoon, and W. Gu, Reactivating the ARF-p53 axis in AML cells by targeting ULF, Cell Cycle Georget. Tex, vol.9, pp.2946-2951, 2010.

Y. Xie and A. Varshavsky, UFD4 lacking the proteasome-binding region catalyses ubiquitination but is impaired in proteolysis, Nat. Cell Biol, vol.4, pp.1003-1007, 2002.

D. Ju, X. Wang, H. Xu, and Y. Xie, The armadillo repeats of the Ufd4 ubiquitin ligase recognize ubiquitin-fusion proteins, FEBS Lett, vol.581, pp.265-270, 2007.

B. R. Keppler and T. K. Archer, Ubiquitin-dependent and ubiquitin-independent control of subunit stoichiometry in the SWI/SNF complex, J. Biol. Chem, vol.285, pp.35665-35674, 2010.

Y. Park, S. K. Yoon, and J. Yoon, TRIP12 functions as an E3 ubiquitin ligase of APP-BP1, Biochem. Biophys. Res. Commun, vol.374, pp.294-298, 2008.

T. Gudjonsson, TRIP12 and UBR5 suppress spreading of chromatin ubiquitylation at damaged chromosomes, Cell, vol.150, pp.697-709, 2012.

D. Chen, Differential effects on ARF stability by normal versus oncogenic levels of c-Myc expression, Mol. Cell, vol.51, pp.46-56, 2013.

S. Kweon, An Adversarial DNA N6-Methyladenine-Sensor Network Preserves Polycomb Silencing, Mol. Cell, 2019.

N. Hanoun, The E3 ubiquitin ligase thyroid hormone receptor-interacting protein 12 targets pancreas transcription factor 1a for proteasomal degradation, J. Biol. Chem, vol.289, pp.35593-35604, 2014.

M. Kajiro, The E3 ubiquitin ligase activity of Trip12 is essential for mouse embryogenesis, PloS One, vol.6, p.25871, 2011.

D. Chen, regulation in oncogenic stress-mediated p53 responses, Nature, vol.464, pp.624-627, 2010.

J. Cai, Ubiquitin-specific protease 7 accelerates p14(ARF) degradation by deubiquitinating thyroid hormone receptorinteracting protein 12 and promotes hepatocellular carcinoma progression, Hepatol. Baltim. Md, vol.61, pp.1603-1614, 2015.

L. Wang, TRIP12 as a mediator of human papillomavirus/p16-related radiation enhancement effects, Oncogene, vol.36, pp.820-828, 2017.

B. J. O'roak, Recurrent de novo mutations implicate novel genes underlying simplex autism risk, Nat. Commun, vol.5, p.5595, 2014.

N. C. Bramswig, Identification of new TRIP12 variants and detailed clinical evaluation of individuals with non-syndromic intellectual disability with or without autism, Hum. Genet, vol.136, pp.179-192, 2017.

K. Siddiqui, K. F. On, and J. F. Diffley, Regulating DNA replication in eukarya, Cold Spring Harb. Perspect. Biol, vol.5, 2013.

Y. F. Lau and F. E. Arrighi, Studies of mammalian chromosome replication. II. Evidence for the existence of defined chromosome replicating units, Chromosoma, vol.83, pp.721-741, 1981.

W. G. Dunphy, L. Brizuela, D. Beach, and J. Newport, The Xenopus cdc2 protein is a component of MPF, a cytoplasmic regulator of mitosis, Cell, vol.54, pp.423-431, 1988.

L. L. Parker and H. Piwnica-worms, Inactivation of the p34cdc2-cyclin B complex by the human WEE1 tyrosine kinase, Science, vol.257, pp.1955-1957, 1992.

, Scientific RepoRtS |, vol.10, p.789, 2020.

J. R. Mclean, D. Chaix, M. D. Ohi, and K. L. Gould, State of the APC/C: organization, function, and structure, Crit. Rev. Biochem. Mol. Biol, vol.46, pp.118-136, 2011.

A. Musacchio and E. D. Salmon, The spindle-assembly checkpoint in space and time, Nat. Rev. Mol. Cell Biol, vol.8, pp.379-393, 2007.

J. A. Pesin and T. L. Orr-weaver, Regulation of APC/C activators in mitosis and meiosis, Annu. Rev. Cell Dev. Biol, vol.24, pp.475-499, 2008.

N. J. Ganem and D. Pellman, Linking abnormal mitosis to the acquisition of DNA damage, J. Cell Biol, vol.199, pp.871-881, 2012.

K. Crasta, DNA breaks and chromosome pulverization from errors in mitosis, Nature, vol.482, pp.53-58, 2012.

R. Aviner, A. Shenoy, O. Elroy-stein, and T. Geiger, Uncovering Hidden Layers of Cell Cycle Regulation through Integrative Multiomic Analysis, PLoS Genet, vol.11, p.1005554, 2015.

R. Van-der-lee, Classification of intrinsically disordered regions and proteins, Chem. Rev, vol.114, pp.6589-6631, 2014.

B. R. Sabari, Coactivator condensation at super-enhancers links phase separation and gene control, Science, vol.361, 2018.

J. Pines and T. Hunter, Isolation of a human cyclin cDNA: evidence for cyclin mRNA and protein regulation in the cell cycle and for interaction with p34cdc2, Cell, vol.58, pp.833-846, 1989.

G. H. Enders, Gauchos and ochos: a Wee1-Cdk tango regulating mitotic entry, Cell Div, vol.5, p.12, 2010.

A. Lindqvist, W. Van-zon, C. Karlsson-rosenthal, and R. M. Wolthuis, Cyclin B1-Cdk1 activation continues after centrosome separation to control mitotic progression, PLoS Biol, vol.5, p.123, 2007.

D. Coverley, H. Laman, and R. A. Laskey, Distinct roles for cyclins E and A during DNA replication complex assembly and activation, Nat. Cell Biol, vol.4, pp.523-528, 2002.

C. Li, M. Andrake, R. Dunbrack, and G. H. Enders, A bifunctional regulatory element in human somatic Wee1 mediates cyclin A/ Cdk2 binding and Crm1-dependent nuclear export, Mol. Cell. Biol, vol.30, pp.116-130, 2010.

N. Den-elzen and J. Pines, Cyclin A is destroyed in prometaphase and can delay chromosome alignment and anaphase, J. Cell Biol, vol.153, pp.121-136, 2001.

L. De-boer, Cyclin A/cdk2 coordinates centrosomal and nuclear mitotic events, Oncogene, vol.27, pp.4261-4268, 2008.

M. L. Whitfield, Identification of Genes Periodically Expressed in the Human Cell Cycle and Their Expression in Tumors, Mol. Biol. Cell, vol.13, 1977.

T. Dobson, J. Chen, and L. A. Krushel, Dysregulating IRES-Dependent Translation Contributes to Overexpression of Oncogenic Aurora A Kinase, Mol. Cancer Res, vol.11, pp.887-900, 2013.

W. Chen, J. M. Smeekens, and R. Wu, Systematic study of the dynamics and half-lives of newly synthesized proteins in human cells, Chem. Sci, vol.7, pp.1393-1400, 2016.

H. Ma, M phase phosphorylation of the epigenetic regulator UHRF1 regulates its physical association with the deubiquitylase USP7 and stability, Proc. Natl. Acad. Sci. USA, vol.109, pp.4828-4833, 2012.

A. Petrone, M. E. Adamo, C. Cheng, and A. N. Kettenbach, Identification of Candidate Cyclin-dependent kinase 1 (Cdk1) Substrates in Mitosis by Quantitative Phosphoproteomics, Mol. Cell. Proteomics MCP, vol.15, pp.2448-2461, 2016.

H. J. Dyson and P. E. Wright, Intrinsically unstructured proteins and their functions, Nat. Rev. Mol. Cell Biol, vol.6, pp.197-208, 2005.

Z. Peng and L. Kurgan, High-throughput prediction of RNA, DNA and protein binding regions mediated by intrinsic disorder, Nucleic Acids Res, vol.43, p.121, 2015.

C. Wang, V. N. Uversky, and L. Kurgan, Disordered nucleiome: Abundance of intrinsic disorder in the DNA-and RNA-binding proteins in 1121 species from Eukaryota, Bacteria and Archaea, Proteomics, vol.16, pp.1486-1498, 2016.

A. Maréchal, PRP19 transforms into a sensor of RPA-ssDNA after DNA damage and drives ATR activation via a ubiquitinmediated circuitry, Mol. Cell, vol.53, pp.235-246, 2014.

W. A. Braden, A. K. Mcclendon, and E. S. Knudsen, Cyclin-dependent kinase 4/6 activity is a critical determinant of pre-replication complex assembly, Oncogene, vol.27, pp.7083-7093, 2008.

C. Demeret, Y. Vassetzky, and M. Méchali, Chromatin remodelling and DNA replication: from nucleosomes to loop domains, Oncogene, vol.20, pp.3086-3093, 2001.

Q. Cao, The central role of EED in the orchestration of polycomb group complexes, Nat. Commun, vol.5, p.3127, 2014.

G. Oliviero, Dynamic Protein Interactions of the Polycomb Repressive Complex 2 during Differentiation of Pluripotent Cells, Mol. Cell. Proteomics MCP, vol.15, pp.3450-3460, 2016.

S. Abe, The initial phase of chromosome condensation requires Cdk1-mediated phosphorylation of the CAP-D3 subunit of condensin II, Genes Dev, vol.25, pp.863-874, 2011.

R. S. Wu, K. W. Kohn, and W. M. Bonner, Metabolism of ubiquitinated histones, J. Biol. Chem, vol.256, pp.5916-5920, 1981.

M. Arora, Promoters active in interphase are bookmarked during mitosis by ubiquitination, Nucleic Acids Res, vol.40, pp.10187-10202, 2012.

S. Giunta, R. Belotserkovskaya, and S. P. Jackson, DNA damage signaling in response to double-strand breaks during mitosis, J. Cell Biol, vol.190, pp.197-207, 2010.

D. Nakajima, Preparation of a set of expression-ready clones of mammalian long cDNAs encoding large proteins by the ORF trap cloning method, DNA Res. Int. J. Rapid Publ. Rep. Genes Genomes, vol.12, pp.257-267, 2005.

J. Torrisani, let-7 MicroRNA transfer in pancreatic cancer-derived cells inhibits in vitro cell proliferation but fails to alter tumor progression, Hum Gene Ther, vol.20, pp.831-875, 2009.
URL : https://hal.archives-ouvertes.fr/inserm-00409952

Z. Dosztányi, V. Csizmók, P. Tompa, and I. Simon, The pairwise energy content estimated from amino acid composition discriminates between folded and intrinsically unstructured proteins, J. Mol. Biol, vol.347, pp.827-839, 2005.

R. Linding, R. B. Russell, V. Neduva, T. J. Gibson, and . Globplot, Exploring protein sequences for globularity and disorder, Nucleic Acids Res, vol.31, pp.3701-3708, 2003.

R. Linding, Protein disorder prediction: implications for structural proteomics, Struct. Lond. Engl, vol.11, pp.1453-1459, 1993.