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Metastatic Solitary Fibrous Tumor With Doege-Potter Syndrome : Hypoglycemia Treated by 90 Y Radioembolization

Abstract : Solitary fibrous tumor is a rare type of mesenchymal neoplasm that can be associated to a paraneoplastic severe hypoglycemia due to the overproduction of insulinlike growth factor type 2: Doege-Potter syndrome. When surgical resection is impossible or unsuccessful, alternative therapies were described with heterogeneous efficiency. We report the use of radioembolization with 90 Y-labeled glass microspheres in this application. Regarding the excellent results obtained and the potential interest of peptide receptor radionuclide therapy suggested by overexpression of somatostatin receptors in our patient, the place of targeted radionuclide therapies deserves to be explored in this group of tumors.
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Submitted on : Wednesday, February 19, 2020 - 4:13:16 PM
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Clément Bailly, Myriam Bichali Alroumani, Frédéric Douane, Catherine Ansquer, Delphine Drui. Metastatic Solitary Fibrous Tumor With Doege-Potter Syndrome : Hypoglycemia Treated by 90 Y Radioembolization. Clinical Nuclear Medicine, Lippincott, Williams & Wilkins, 2017, 43 (3), pp.e93-e95. ⟨10.1097/RLU.0000000000001944⟩. ⟨inserm-02484758⟩

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