Skip to Main content Skip to Navigation
Journal articles

Is antigen specificity the key to efficient adoptive T‑cell therapy?

Abstract : Adoptive transfer of T cells remains a promising approach in melanoma. Initial clinical trials performed with polyclonal tumor-infiltrating lymphocyte gave limited clinical results. Nonetheless, encouraging results have been reported in adjuvant setting (stage III melanoma), and when tumor-infiltrating lymphocytes were associated with lymphodepleting regimens. Specificity of adoptive cell therapy has been achieved with the infusion of antigen specific cytotoxic T-lymphocyte clones, associated with some clinical responses. Antigen specificity can also be obtained by the allogeneic transfer of high-avidity T-cell receptors into autologous T cells. We propose an alternative strategy based on the selection of antigen-specific T cells with magnetic beads coated with HLA-peptide multimers. Future improvements of adoptive melanoma immunotherapy may be achieved by its association with other therapeutic strategies such as targeted therapy against signaling pathways.
Complete list of metadatas

Cited literature [63 references]  Display  Hide  Download

https://www.hal.inserm.fr/inserm-02481934
Contributor : Nathalie Labarriere <>
Submitted on : Monday, February 17, 2020 - 5:14:32 PM
Last modification on : Friday, June 19, 2020 - 3:08:56 AM
Long-term archiving on: : Monday, May 18, 2020 - 6:54:10 PM

File

 Restricted access
To satisfy the distribution rights of the publisher, the document is embargoed until : jamais

Please log in to resquest access to the document

Identifiers

Collections

Citation

Nathalie Labarrière, Amir Khammari, François Lang, Brigitte Dreno. Is antigen specificity the key to efficient adoptive T‑cell therapy?. Immunotherapy, Future Medicine, 2011, ⟨10.2217/IMT.11.16⟩. ⟨inserm-02481934⟩

Share

Metrics

Record views

105