Skip to Main content Skip to Navigation

Decoding and unlocking the BCL‐2 dependency of cancer cells

Abstract : Cancer cells are subject to many apoptotic stimuli that would kill them were it not for compensatory prosurvival alterations. BCL‐2‐like (BCL‐2L) proteins contribute to such aberrant behaviour by engaging a network of interactions that is potent at promoting survival but that is also fragile: inhibition of a restricted number of interactions may suffice to trigger cancer cell death. Currently available and novel compounds that inhibit these interactions could be efficient therapeutic agents if this phenotype of BCL‐2L dependence was better understood at a molecular, cellular and systems level and if it could be diagnosed by relevant biomarkers.
Document type :
Journal articles
Complete list of metadatas

Cited literature [131 references]  Display  Hide  Download

https://www.hal.inserm.fr/inserm-02481124
Contributor : Philippe Paul Juin <>
Submitted on : Monday, February 17, 2020 - 11:51:49 AM
Last modification on : Tuesday, February 18, 2020 - 1:32:08 AM

File

 Restricted access
To satisfy the distribution rights of the publisher, the document is embargoed until : jamais

Please log in to resquest access to the document

Identifiers

Collections

Citation

Philippe Juin, Olivier Geneste, Fabien Gautier, Stéphane Depil, Mario Campone. Decoding and unlocking the BCL‐2 dependency of cancer cells. Nature Reviews Cancer, Nature Publishing Group, 2013, 13 (7), pp.455-465. ⟨10.1038/nrc3538⟩. ⟨inserm-02481124⟩

Share

Metrics

Record views

18