Skip to Main content Skip to Navigation
Journal articles

Decoding and unlocking the BCL‐2 dependency of cancer cells

Abstract : Cancer cells are subject to many apoptotic stimuli that would kill them were it not for compensatory prosurvival alterations. BCL‐2‐like (BCL‐2L) proteins contribute to such aberrant behaviour by engaging a network of interactions that is potent at promoting survival but that is also fragile: inhibition of a restricted number of interactions may suffice to trigger cancer cell death. Currently available and novel compounds that inhibit these interactions could be efficient therapeutic agents if this phenotype of BCL‐2L dependence was better understood at a molecular, cellular and systems level and if it could be diagnosed by relevant biomarkers.
Document type :
Journal articles
Complete list of metadata

Cited literature [131 references]  Display  Hide  Download
Contributor : Philippe Paul JUIN Connect in order to contact the contributor
Submitted on : Monday, February 17, 2020 - 11:51:49 AM
Last modification on : Wednesday, November 10, 2021 - 3:32:04 PM
Long-term archiving on: : Monday, May 18, 2020 - 2:56:30 PM


 Restricted access
To satisfy the distribution rights of the publisher, the document is embargoed until : jamais

Please log in to resquest access to the document




Philippe Juin, Olivier Geneste, Fabien Gautier, Stéphane Depil, Mario Campone. Decoding and unlocking the BCL‐2 dependency of cancer cells. Nature Reviews Cancer, Nature Publishing Group, 2013, 13 (7), pp.455-465. ⟨10.1038/nrc3538⟩. ⟨inserm-02481124⟩



Record views