D. Sabatino, A. Pickard, K. M. Rampton, and D. , Blockade of transforming growth factor beta upregulates T-box transcription factor T-bet, and increases T helper cell type 1 cytokine and matrix metalloproteinase-3 production in the human gut mucosa, Gut, vol.57, pp.605-612, 2008.

A. Jarry, C. Bossard, and C. Bou-hanna, Mucosal IL-10 and TGFbeta play crucial roles in preventing LPS-driven, IFN-gamma-mediated epithelial damage in human colon explants, J Clin Invest, vol.118, pp.1132-1142, 2008.
URL : https://hal.archives-ouvertes.fr/hal-00277246

W. Strober, I. Fuss, and P. Mannon, The fundamental basis of inflammatory bowel disease, J Clin Invest, vol.117, pp.514-521, 2007.

G. Monteleone, D. V. Blanco, G. Monteleone, and I. , Posttranscriptional regulation of Smad7 in the gut of patients with inflammatory bowel disease, Gastroenterology, vol.129, pp.1420-1429, 2005.

I. Correa, M. Veny, and M. Esteller, Defective IL-10 production in severe phenotypes of Crohn's disease, J Leukoc Biol, vol.85, pp.896-903, 2009.

E. Noguchi, Y. Homma, and X. Kang, A Crohn's disease-associated NOD2 mutation suppresses transcription of human IL10 by inhibiting activity of the nuclear ribonucleoprotein hnRNP-A1, Nat Immunol, vol.10, pp.471-479, 2009.

E. O. Glocker, D. Kotlarz, and K. Boztug, Inflammatory bowel disease and mutations affecting the interleukin-10 receptor, N Engl J Med, vol.361, pp.2033-2045, 2009.

G. Trinchieri, Interleukin-12 and the regulation of innate resistance and adaptive immunity, Nat Rev Immunol, vol.3, pp.133-146, 2003.

F. Martinon and J. Tschopp, Inflammatory caspases: linking an intracellular innate immune system to autoinflammatory diseases, Cell, vol.117, pp.561-574, 2004.

F. Martinon, A. Mayor, and J. Tschopp, The inflammasomes: guardians of the body, Annu Rev Immunol, vol.27, pp.229-265, 2009.

G. Monteleone, L. Biancone, and R. Marasco, Interleukin 12 is expressed and actively released by Crohn's disease intestinal lamina propria mononuclear cells, Gastroenterology, vol.112, pp.1169-1178, 1997.

T. T. Pizarro, M. H. Michie, and M. Bentz, IL-18, a novel immunoregulatory cytokine, is up-regulated in Crohn's disease: expression and localization in intestinal mucosal cells, J Immunol, vol.162, pp.6829-6835, 1999.

I. J. Fuss, C. Becker, and Z. Yang, Both IL-12p70 and IL-23 are synthesized during active Crohn's disease and are down-regulated by treatment with anti-IL-12 p40 monoclonal antibody, Inflamm Bowel Dis, vol.12, pp.9-15, 2006.

A. Jarry, K. Bach-ngohou, and D. Masson, Human colonic myocytes are involved in postischemic inflammation through ADAM17 dependent TNFalpha production, Br J Pharmacol, vol.147, pp.64-72, 2006.

A. Tsiavou, D. Degiannis, and E. Hatziagelaki, Flow cytometric detection of intracellular IL-12 release: in vitro effect of widely used immunosuppressants, Int Immunopharmacol, vol.2, pp.1713-1720, 2002.

A. A. Te-velde, Y. Van-kooyk, and H. Braat, Increased expression of DC-SIGN?IL-12?IL-18? and CD83?IL-12-IL-18-dendritic cell populations in the colonic mucosa of patients with Crohn's disease, Eur J Immunol, vol.33, pp.143-151, 2003.

D. Novick, S. H. Kim, and G. Fantuzzi, Interleukin-18 binding protein: a novel modulator of the Th1 cytokine response, Immunity, vol.10, pp.127-136, 1999.

A. B. Kulkarni, C. G. Huh, and D. Becker, Transforming growth factor beta 1 null mutation in mice causes excessive inflammatory response and early death, Proc Natl Acad Sci, vol.90, pp.770-774, 1993.

K. B. Hahm, Y. H. Im, and T. W. Parks, Loss of transforming growth factor beta signalling in the intestine contributes to tissue injury in inflammatory bowel disease, Gut, vol.49, pp.190-198, 2001.

D. M. Rennick and M. M. Fort, Lessons from genetically engineered animal models. XII. IL-10-deficient (IL-10-/-) mice and intestinal inflammation, Am J Physiol, vol.278, pp.829-833, 2000.

B. R. Ludviksson, R. O. Ehrhardt, and W. Strober, TGF-beta production regulates the development of the 2,4,6-trinitrophenol-conjugated keyhole limpet hemocyanin-induced colonic inflammation in IL-2-deficient mice, J Immunol, vol.159, pp.3622-3628, 1997.

I. J. Fuss, M. Boirivant, and B. Lacy, The interrelated roles of TGF-beta and IL-10 in the regulation of experimental colitis, J Immunol, vol.168, pp.900-908, 2002.

A. Kitani, I. J. Fuss, and K. Nakamura, Treatment of experimental (Trinitrobenzene sulfonic acid) colitis by intranasal administration of transforming growth factor (TGF)-beta1 plasmid: TGF-beta1-mediated suppression of T helper cell type 1 response occurs by interleukin (IL)-10 induction and IL-12 receptor beta2 chain downregulation, J Exp Med, vol.192, pp.41-52, 2000.

I. Castagliuolo, P. Brun, and D. Tormen, Lymphocytes endowed with colon-selective homing and engineered to produce TGF-beta1 prevent the development of dinitrobenzene sulphonic acid colitis, Eur J Gastroenterol Hepatol, vol.15, pp.1257-1265, 2003.

M. F. Neurath, I. Fuss, and B. L. Kelsall, Antibodies to interleukin 12 abrogate established experimental colitis in mice, J Exp Med, vol.182, pp.1281-1290, 1995.

G. Fantuzzi, D. A. Reed, and C. A. Dinarello, IL-12-induced IFN-gamma is dependent on caspase-1 processing of the IL-18 precursor, J Clin Invest, vol.104, pp.761-767, 1999.

S. K. Bliss, B. A. Butcher, and E. Y. Denkers, Rapid recruitment of neutrophils containing prestored IL-12 during microbial infection, J Immunol, vol.165, pp.4515-4521, 2000.

M. Quinones, S. K. Ahuja, and P. C. Melby, Preformed membraneassociated stores of interleukin (IL)-12 are a previously unrecognized source of bioactive IL-12 that is mobilized within minutes of contact with an intracellular parasite, J Exp Med, vol.192, pp.507-516, 2000.

A. Jarry, G. Vallette, and E. Cassagnau, Interleukin 1 and interleukin 1beta converting enzyme (caspase 1) expression in the human colonic epithelial barrier. Caspase 1 downregulation in colon cancer, Gut, vol.45, pp.246-251, 1999.

M. E. Mcalindon, C. J. Hawkey, and Y. R. Mahida, Expression of interleukin 1 beta and interleukin 1 beta converting enzyme by intestinal macrophages in health and inflammatory bowel disease, Gut, vol.42, pp.214-219, 1998.

K. Barbulescu, C. Becker, and J. F. Schlaak, IL-12 and IL-18 differentially regulate the transcriptional activity of the human IFNgamma promoter in primary CD4? T lymphocytes, J Immunol, vol.160, pp.3642-3647, 1998.

H. Helmby and R. K. Grencis, IFN-gamma-independent effects of IL-12 during intestinal nematode infection, J Immunol, vol.171, pp.3691-3696, 2003.

Z. E. Wang, C. Zheng, and . Db, Interferon gamma-independent effects of interleukin 12 administered during acute or established infection due to Leishmania major, Proc Natl Acad Sci U S A, vol.91, pp.12932-12936, 1994.