Synthesis, anti-mycobacterial and cytotoxic evaluation of substituted isoindoline-1,3-dione-4-aminoquinolines coupled via alkyl/amide linkers
Résumé
A series of secondary amine-substituted isoindoline-1,3-dione-4-aminoquinolines were prepared via
microwave heating and assayed for their anti-mycobacterial activities. The compound with a butyl chain
as a spacer between the two pharmacophores and piperidine as the secondary amine component on
the isoindoline ring was the most potent and non-cytotoxic among the synthesized compounds,
exhibiting a minimum inhibitory concentration (MIC99) of 6.25 mg mL1 against Mycobacterium
tuberculosis.
Domaines
Microbiologie et Parasitologie
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