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Journal articles
Synthesis, anti-mycobacterial and cytotoxic evaluation of substituted isoindoline-1,3-dione-4-aminoquinolines coupled via alkyl/amide linkers
Abstract : A series of secondary amine-substituted isoindoline-1,3-dione-4-aminoquinolines were prepared via
microwave heating and assayed for their anti-mycobacterial activities. The compound with a butyl chain
as a spacer between the two pharmacophores and piperidine as the secondary amine component on
the isoindoline ring was the most potent and non-cytotoxic among the synthesized compounds,
exhibiting a minimum inhibitory concentration (MIC99) of 6.25 mg mL1 against Mycobacterium
tuberculosis.
Cited literature [143 references]
https://www.hal.inserm.fr/inserm-02480348
Contributor : Laurent Kremer <>
Submitted on : Sunday, February 16, 2020 - 8:01:28 AM
Last modification on : Tuesday, February 18, 2020 - 1:32:08 AM
Long-term archiving on: : Sunday, May 17, 2020 - 12:27:50 PM
Contributor : Laurent Kremer <>
Submitted on : Sunday, February 16, 2020 - 8:01:28 AM
Last modification on : Tuesday, February 18, 2020 - 1:32:08 AM
Long-term archiving on: : Sunday, May 17, 2020 - 12:27:50 PM