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Synthesis, anti-mycobacterial and cytotoxic evaluation of substituted isoindoline-1,3-dione-4-aminoquinolines coupled via alkyl/amide linkers

Abstract : A series of secondary amine-substituted isoindoline-1,3-dione-4-aminoquinolines were prepared via microwave heating and assayed for their anti-mycobacterial activities. The compound with a butyl chain as a spacer between the two pharmacophores and piperidine as the secondary amine component on the isoindoline ring was the most potent and non-cytotoxic among the synthesized compounds, exhibiting a minimum inhibitory concentration (MIC99) of 6.25 mg mL1 against Mycobacterium tuberculosis.
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https://www.hal.inserm.fr/inserm-02480348
Contributor : Laurent Kremer <>
Submitted on : Sunday, February 16, 2020 - 8:01:28 AM
Last modification on : Tuesday, February 18, 2020 - 1:32:08 AM
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Anu Rani, Albertus Viljoen, Matt Johansen, Laurent Kremer, Vipan Kumar. Synthesis, anti-mycobacterial and cytotoxic evaluation of substituted isoindoline-1,3-dione-4-aminoquinolines coupled via alkyl/amide linkers. RSC Advances, Royal Society of Chemistry, 2019, 9 (15), pp.8515-8528. ⟨10.1039/C8RA10532D⟩. ⟨inserm-02480348⟩

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