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Design, synthesis, anti‐mycobacterial and cytotoxic evaluation of C‐4 functionalized 1,8‐naphthalimide‐heterocyclic hydrazide conjugates
Abstract : This manuscript discloses the design and synthesis of a series of C-4 functionalized 1,8-naphthalimide-heterocyclic hydrazide conjugates along with their anti-mycobacterial and cytotoxic evaluation. The present work assumes significance as it describes the first report on the amalgamation of C-4 substituted naphthalimides with various heterocyclic hydrazides. However, contrary to the rationale behind the synthesis of the conjugates, none of them inhibited the growth of Mycobacterium tuberculosis at the tested concentrations though these were non-cytotoxic towards the Vero kidney epithelial cell line.
https://www.hal.inserm.fr/inserm-02480347
Contributor : Laurent Kremer <>
Submitted on : Sunday, February 16, 2020 - 7:59:36 AM
Last modification on : Tuesday, February 18, 2020 - 1:32:07 AM
Contributor : Laurent Kremer <>
Submitted on : Sunday, February 16, 2020 - 7:59:36 AM
Last modification on : Tuesday, February 18, 2020 - 1:32:07 AM
