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Design, synthesis, anti‐mycobacterial and cytotoxic evaluation of C‐4 functionalized 1,8‐naphthalimide‐heterocyclic hydrazide conjugates

Abstract : This manuscript discloses the design and synthesis of a series of C-4 functionalized 1,8-naphthalimide-heterocyclic hydrazide conjugates along with their anti-mycobacterial and cytotoxic evaluation. The present work assumes significance as it describes the first report on the amalgamation of C-4 substituted naphthalimides with various heterocyclic hydrazides. However, contrary to the rationale behind the synthesis of the conjugates, none of them inhibited the growth of Mycobacterium tuberculosis at the tested concentrations though these were non-cytotoxic towards the Vero kidney epithelial cell line.
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Journal articles
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https://www.hal.inserm.fr/inserm-02480347
Contributor : Laurent Kremer <>
Submitted on : Sunday, February 16, 2020 - 7:59:36 AM
Last modification on : Tuesday, February 18, 2020 - 1:32:07 AM

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Shalini Shalini, Matt Johansen, Laurent Kremer, Vipan Kumar. Design, synthesis, anti‐mycobacterial and cytotoxic evaluation of C‐4 functionalized 1,8‐naphthalimide‐heterocyclic hydrazide conjugates. Chemical Biology and Drug Design, Wiley, 2019, 94 (1), pp.1300-1305. ⟨10.1111/cbdd.13503⟩. ⟨inserm-02480347⟩

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