Black spots concentrate oncogenic 1003 asbestos fibers in the parietal pleura: thoracoscopic and mineralogic study, p.1004 ,
, Jaurand MC. Use of in-vitro genotoxicity and cell transformation assays to evaluate 1006 potential carcinogenicity of fibres, Mechanisms in Fiber Carcinogenesis, vol.153, pp.55-72, 1996.
Role of mutagenicity in 1009 asbestos fiber-induced carcinogenicity and other diseases, Journal of Toxicology, vol.14, pp.1-67, 1010. ,
Mechanisms of fiber-induced genotoxicity, Environ Health, p.1012 ,
, Perspect, vol.105, pp.1073-1084, 1997.
Aberrations of chromosome 19 in 1014 asbestos-associated lung cancer and in asbestos-induced micronuclei of bronchial 1015 epithelial cells in vitro, Carcinogenesis, vol.29, pp.913-917, 2008. ,
Asbestos causes stimulation of the 1017 extracellular signal-regulated kinase 1 mitogen-activated protein kinase cascade after 1018 phosophorylation of the epidermal growth factor receptor, Carcinogenesis, vol.56, pp.2275-2280, 1020. ,
Analysis of cell cycle disruptions in cultures 1024 of rat pleural mesothelial cells exposed to asbestos fibres, Amer J Respir Cell Mol ,
Phagocytosis of crocidolite asbestos induces oxidative 1033 stress, DNA damage, and apoptosis in mesothelial cells, Am J Respir cell Mol, p.1034 ,
Modulation of DNA single-strand breaks by 1036 intracellular glutathione in human lung cells exposed to asbestos fibers, Biol, vol.23, pp.371-378, 1035. ,
, Res, vol.514, pp.7-17, 2002.
SV40 oncoproteins enhance asbestos-induced DNA double-1039 strand breaks and abrogate senescence in murine mesothelial cells ,
, Res, vol.67, pp.3637-3645, 2007.
Role of oxygen 1042 derivatives in the cytotoxicity and DNA damage produced by asbestos on rat pleural 1043 mesothelial cells in vitro, Carcinogenesis, vol.15, pp.1251-1255, 1994. ,
, Synthesis of poly
, asbestos treated rat pleural mesothelial cells in culture. Mutat
, Res, vol.331, pp.197-204, 1995.
Sister chromatid exchanges in rat pleural 1048 mesothelial cells treated with crocidolite, attapulgite or benzo 3-4 pyrene, Br J Ind, p.1049 ,
, , vol.44, pp.281-283, 1987.
The interactions 1051 between asbestos fibers and metaphase chromosomes of rat pleural mesothelial cells in 1052 culture. A scanning and transmission electron microscopic study, Am J, vol.1053, p.60 ,
Epidemiology of malignant mesothelioma--an outline, Ann Occup, p.1095 ,
, , vol.54, pp.851-857, 2010.
Mortality in a cohort of vermiculite miners exposed 1097 to fibrous amphibole in Libby, Montana. Occup Environ Med, vol.61, pp.39-143, 2004. ,
Particle length-1101 dependent titanium dioxide nanomaterials toxicity and bioactivity, p.1102 ,
, Toxicol, vol.6, p.35, 2009.
Innate immune 1104 activation through Nalp3 inflammasome sensing of asbestos and silica ,
, Science, vol.320, pp.674-677, 2008.
Carbon nanotubes introduced into the abdominal 1107 cavity of mice show asbestos-like pathogenicity in a pilot study ,
, Nanotechnol, vol.3, pp.423-428, 2008.
, Chapter ex15 new22Revised Vf(text and tables
Absence of carcinogenic 1126 response to multiwall carbon nanotubes in a 2-year bioassay in the peritoneal cavity of the 1127 rat, Toxicol Sci, vol.110, pp.442-448, 2009. ,
Clinical aspects of the toxicity of inhaled mineral dusts, p.1129 ,
, Soc Rev, vol.28, pp.373-381, 1999.
The effect of iron binding on the ability of crocidolite asbestos to 1133 catalyze DNA single-strand breaks, Carcinogenesis, vol.3, pp.319-325, 1995. ,
Cell signaling and transcription factor activation 1135 by asbestos in lung injury and disease, Intl J Biochem Cell Biol, vol.35, pp.1198-1209, 2003. ,
Asbestos-induced pulmonary toxicity: role of DNA damage and 1137 apoptosis, Exp Biol Med (Maywood), vol.228, pp.650-659, 2003. ,
Free radical activity of synthetic vitreous fibers: iron 1139 chelation inhibits hydroxyl radical generation by refractory ceramic fiber, J Toxicol, p.1140 ,
Biological efects of naturally occurring and man-made fibres : 1142 in vitro cytotoxicity and mutagenesis in mammalian cells, Free Radic Biol Med, vol.53, pp.1227-1233, 1144. ,
Erionite exposure and mesotheliomas in 1216 rats, British Journal of Cancer, p.51, 1985. ,
Pluripotential nature of 1218 mesotheliomata induced by inhalation of erionite in rats, Br J Exp Pathol, vol.65, pp.377-1219, 1984. ,
Animal models of malignant mesothelioma, Inhal Toxicol, vol.18, pp.1001-1004, 2006. ,
Meosthelioma carcinogenesis: In vivo models, Pass H, Vogelzang N, p.1222 ,
, Malignant mesothelioma, vol.26, pp.60-86, 2005.
Targeted Removal of Bioavailable Metal as 1224 a Detoxification Strategy for Carbon Nanotubes, Carbon N Y, vol.46, pp.489-500, 2008. ,
Biodegradation of single-walled carbon 1226 nanotubes through enzymatic catalysis, Nano Lett, vol.8, pp.3899-3903, 2008. ,
Biodurability of Single-Walled Carbon Nanotubes Depends 1228 on Surface Functionalization, Carbon N Y, vol.48, pp.1961-1969, 2010. ,
Biopersistent fiber-induced inflammation and carcinogenesis: 1230 lessons learned from asbestos toward safety of fibrous nanomaterials, Arch Biochem, p.1231 ,
, , vol.502, pp.1-7, 2010.
Carbon nanotubes: a review of their properties in 1233 relation to pulmonary toxicology and workplace safety, Toxicol Sci, vol.92, pp.5-22, 2006. ,
Single-and multi-wall carbon nanotubes versus 1235 asbestos: are the carbon nanotubes a new health risk to humans?, J Toxicol Environ Health ,
, , vol.73, pp.378-395, 2010.
Inflammation-mediated cytosine damage: a mechanistic link 1278 between inflammation and the epigenetic alterations in human cancers, Cancer ,
, Res, vol.67, pp.5583-5586, 2007.
DNA methylation at the C-5 position of cytosine by methyl radicals: a 1281 possible role for epigenetic change during carcinogenesis by environmental agents, p.1282 ,
, Res Toxicol, vol.22, pp.984-989, 2009.
Oxidative stress, inflammation, and 1284 cancer: how are they linked?, Free Radic Biol Med, vol.49, pp.1603-1616, 2010. ,
The mesothelial cell, Int J Biochem Cell Biol, vol.36, pp.9-16, 2004. ,
Serosal membranes (pleura, pericardium, peritoneum) ,
, Normal structure, development and experimental pathology, Adv Anat Embryol Cell
, Biol, vol.183, pp.1-144, 2006.
Mesothelial regeneration is not dependent 1290 on subserosal cells, J Pathol, vol.190, pp.86-92, 2000. ,
Mesothelial cells: their structure, function and role in serosal repair ,
, Respirology, vol.7, pp.171-191, 2002.
,
, Evidence for incorporation of free-floating mesothelial cells as a mechanism of serosal 1295 healing, J Cell Sci, vol.115, pp.1383-1389, 2002.
Absence of p53 mutations in malignant mesothelioma ,
, Am J Respir Cell Mol Biol, vol.16, pp.9-13, 1997.
Accelerated progression of asbestos-induced 1338 mesotheliomas in heterozygous p53 (+/-) mice, Toxicol Sci, vol.68, pp.331-338, 2002. ,
Syntenic relationships between genomic profiles of 1340 fiber-induced murine and human malignant mesothelioma, Am J Pathol, vol.176, pp.881-1341, 2011. ,
High frequency of inactivating mutations in the 1343 neurofibromatosis type 2 gene (NF2) in primary malignant mesothelioma, Proc Natl Acad ,
, , vol.92, pp.10854-10858, 1995.
Neurofibromatosis type 1346 2 (NF2) gene is somatically mutated in mesothelioma but not in lung cancer, Cancer ,
, Res, vol.55, pp.1227-1231, 1995.
NF2 deficiency 1349 promotes tumorigenesis and metastasis by destabilizing adherens junctions, Genes ,
, Dev, vol.17, pp.1090-1100, 2003.
, A Tight Junction-Associated Merlin-Angiomotin
, Complex Mediates Merlin's Regulation of Mitogenic Signaling and Tumor Suppressive 1353 Functions, Cancer Cell, vol.19, pp.527-540, 2010.
Merlin, a "magic" linker between extracellular cues and 1355 intracellular signaling pathways that regulate cell motility, proliferation, and survival ,
, Curr Protein Pept Sci, vol.11, pp.471-484, 2010.
Nonrandom chromosomal 1358 abnormalities in malignant pleural mesothelioma, Cancer Genet Cytogenet, vol.33, pp.251-1359, 1988. ,
Chromosome 1369 number correlates with survival in patients with malignant pleural mesothelioma ,
, Genet Cytogenet, vol.62, pp.21-24, 1992.
Gains and losses of DNA sequences in 1372 malignant mesothelioma by comparative genomic hybridization, Cancer Genet, p.1373 ,
, Cytogenet, vol.89, pp.7-13, 1996.
Gene copy number analysis in 1375 malignant pleural mesothelioma using oligonucleotide array CGH, Cytogenet Genome, p.1376 ,
, Res, vol.119, pp.46-52, 2007.
Genomic events associated with progression of 1378 pleural malignant mesothelioma, Int J Cancer, vol.124, pp.589-599, 2009. ,
Second generation sequencing of the 1380 mesothelioma tumor genome, PLoS One, vol.5, p.10612, 2010. ,
The promyelocytic leukemia 1382 zinc-finger gene, PLZF, is frequently downregulated in malignant mesothelioma cells and 1383 contributes to cell survival, Oncogene, vol.29, pp.1633-1640, 2010. ,
Integrated Profiling Reveals a Global 1385 Correlation between Epigenetic and Genetic Alterations in Mesothelioma ,
, , vol.70, pp.5686-5694, 2010.
Cytogenetic analysis of malignant 1388 mesothelioma, Cancer Genet Cytogenet, vol.47, pp.1-28, 1990. ,
Recurrent chromosome 6 abnormalities in malignant 1390 mesothelioma, Monaldi Arch Chest Dis, vol.53, pp.228-235, 1998. ,
Chromosomal 1399 abnormalities and their correlations with asbestos exposure and survival in patients with 1400 mesothelioma, Br J Cancer, vol.60, pp.618-626, 1989. ,
Malignant mesothelioma: clinical 1402 characteristics, asbestos mineralogy and chromosomal abnormalities of 41 patients, Eur J, p.1403 ,
, Cancer, vol.28, pp.1373-1379, 1992.
Comparison of DNA copy number 1405 changes in malignant mesothelioma, adenocarcinoma and large-cell anaplastic carcinoma 1406 of the lung, Br J Cancer, vol.77, pp.260-269, 1998. ,
Deletions at 14q in malignant mesothelioma 1408 detected by microsatellite marker analysis, Br J Cancer, vol.81, pp.1111-1115, 1999. ,
Array comparative genomic 1410 hybridization analysis of chromosomal imbalances and their target genes in 1411 gastrointestinal stromal tumors, Genes Chromosomes Cancer, vol.46, pp.564-576, 2007. ,
Distinct DNA methylation profiles in malignant 1413 mesothelioma, lung adenocarcinoma, and non-tumor lung, Lung Cancer, vol.47, pp.193-1414, 2005. ,
Epigenetic profiles distinguish malignant pleural 1416 mesothelioma from lung adenocarcinoma, Cancer Res, vol.69, pp.9073-9082, 2009. ,
DNA methylation profile of 28 potential marker loci in 1418 malignant mesothelioma, Lung Cancer, vol.58, pp.220-230, 2007. ,
Integrative analysis od 1420 microRNA, mRNA and acGH dta reveals asbestos-and histology-related changes in lung ,
Functional 1429 inactivation of NF2/merlin in human mesothelioma, Lung Cancer, vol.64, pp.140-147, 2009. ,
Identification of potential therapeutic targets in 1431 malignant mesothelioma using cell-cycle gene expression analysis, Am J, p.1432 ,
, Pathol, vol.174, pp.762-770, 2009.
Antiproliferative effect of Aurora kinase 1434 targeting in mesothelioma, Lung Cancer, vol.70, pp.271-279, 2010. ,
Malignant 1436 pleural mesothelioma: genome-wide expression patterns reflecting general resistance 1437 mechanisms and a proposal of novel targets, Lung Cancer, vol.67, pp.57-68, 2010. ,
Global gene expression profiling of pleural 1439 mesotheliomas: overexpression of aurora kinases and P16/CDKN2A deletion as 1440 prognostic factors and critical evaluation of microarray-based prognostic prediction ,
, Cancer Res, vol.66, pp.2970-2979, 2006.
The role of stathmin in the regulation of the cell cycle, J Cell, p.1443 ,
, Biochem, vol.93, pp.242-250, 2004.
Stathmin is overexpressed in malignant mesothelioma ,
, Anticancer Res, vol.27, pp.39-44, 2007.
Cell signaling by receptor tyrosine kinases ,
, Cell, vol.141, pp.1117-1134, 2010.
Mitogen-activated protein kinase 1449 expression and activation does not differentiate benign from malignant mesothelial cells ,
, Cancer, vol.103, pp.2427-2433, 2005.
,
VEGF and VEGF type C play an important role in 1459 angiogenesis and lymphangiogenesis in human malignant mesothelioma tumours, Br J, p.1460 ,
, Cancer, vol.81, pp.54-61, 1999.
Co-expression of vascular endothelial growth 1462 factor and its receptor flt-1 in malignant pleural mesothelioma, Respiration, vol.67, pp.36-1463, 2000. ,
Vascular endothelial growth factor is an autocrine 1465 growth factor in human malignant mesothelioma, J Pathol, vol.193, pp.468-475, 2001. ,
Immunohistochemical 1467 expression and distribution of VEGFR-3 in malignant mesothelioma ,
, Cytopathol, vol.35, pp.786-791, 2007.
Update on the molecular biology of malignant 1470 mesothelioma, Cancer, vol.109, pp.1454-1461, 2007. ,
Malignant mesothelioma growth inhibition by agents 1472 that target the VEGF and VEGF-C autocrine loops, Int J Cancer, vol.104, pp.603-610, 2003. ,
Expression of human hyaluronan 1474 synthases in response to external stimuli, Biochem J, vol.348, pp.29-35, 2000. ,
Characterization of the 1476 molecular mechanism involved in the activation of hyaluronan synthetase by platelet-1477 derived growth factor in human mesothelial cells, Biochem J, vol.283, pp.165-170, 1992. ,
Comparison of production of transforming 1479 growth factor-beta and platelet-derived growth factor by normal human mesothelial cells 1480 212. Van der Meeren A, Amer J Respir Cell Mol Biol, vol.8, pp.214-221, 1993. ,
Targeted epidermal growth factor receptor therapy in 1492 malignant pleural mesothelioma: Where do we stand? Cancer Treat Rev, 2010. ,
Selective activation of insulin receptor substrate-1 ,
, pleural mesothelioma cells: association with distinct malignant phenotypes
, Cancer Res, vol.64, pp.7479-7485, 2004.
Molecular pathways in malignant pleural mesothelioma ,
, Cancer Lett, vol.239, pp.183-189, 2006.
, Textbook of 1499 pleural diseases, pp.27-37, 2008.
Normal human mesothelial cells and mesothelioma cell 1501 lines express insulin-like growth factor I and associated molecules, Cancer ,
, Res, vol.53, pp.2858-2864, 1993.
Regulation of matrix metalloprotease activity in malignant 1504 mesothelioma cell lines by growth factors, Thorax, vol.58, pp.198-203, 2003. ,
Functional analysis of c-Met/hepatocyte 1506 growth factor pathway in malignant pleural mesothelioma, Cancer Res, vol.66, pp.352-361, 2006. ,
Combined inhibition of MET and EGFR 1508 suppresses proliferation of malignant mesothelioma cells, Carcinogenesis, vol.30, pp.1097-1509, 2009. ,
Hepatocyte growth 1511 factor/scatter factor and its receptor c-Met are overexpressed and associated with an 1512 increased microvessel density in malignant pleural mesothelioma, J Cancer Res Clin, p.1513 ,
, Oncol, vol.124, pp.291-296, 1998.
Expression of HGF/SF in mesothelioma cell lines 1518 and its effects on cell motility, proliferation and morphology, Br J Cancer, vol.77, pp.1052-1519, 1998. ,
Inhibition of the met receptor in mesothelioma ,
, Clin Cancer Res, vol.11, pp.8122-8130, 2005.
PTEN/MMAC1/TEP1 in signal transduction and 1523 tumorigenesis, Eur J Biochem, vol.263, pp.605-611, 1999. ,
Malignant pleural mesothelioma cells resist 1525 anoikis as quiescent pluricellular aggregates, Cell Death and Differentiation, vol.16, pp.1526-1146, 2009. ,
Human and mouse mesotheliomas exhibit elevated ,
,
, Oncogene, vol.24, pp.6080-6089, 2005.
Activation of the PI3K-AKT pathway in 1531 human malignant mesothelioma cells, Molecular Medicine Reports, vol.2, pp.181-188, 2009. ,
Wnt/beta-catenin signaling in development and disease, Cell, vol.127, pp.469-1533, 2006. ,
Dickkopf-1 antagonizes Wnt signaling independent of beta-1535 catenin in human mesothelioma, Biochem Biophys Res Commun, vol.323, pp.1246-1250, 2004. ,
Secreted frizzled-related protein 4 is silenced by 1537 hypermethylation and induces apoptosis in beta-catenin-deficient human mesothelioma 1538 cells, Cancer Res, vol.65, pp.743-748, 2005. ,
Wnt inhibitory factor-1, a Wnt antagonist, is 1540 silenced by promoter hypermethylation in malignant pleural mesothelioma, Biochem, 1541. ,
, Biophys Res Commun, vol.342, pp.1228-1232, 2006.
Aberrant promoter methylation of WIF-1 and 1543 ,
, SFRP1, 2, 4 genes in mesothelioma, Oncol Rep, vol.24, pp.423-431, 2010.
Apoptosis 1547 and expression of apoptosis regulating proteins bcl-2, mcl-1, bcl-X, and bax in malignant 1548 mesothelioma, Clin Cancer Res, vol.5, pp.3508-3515, 1999. ,
FLIP overexpression inhibits death receptor-1550 induced apoptosis in malignant mesothelial cells, Oncogene, vol.23, pp.7753-7760, 2004. ,
Expression of 1552 bcl-2 family members in malignant pleural mesothelioma, Acta Oncol, vol.45, pp.449-453, 2006. ,
Evaluation of apoptosis 1554 and immunohistochemical expression of the apoptosis-related proteins in mesothelioma ,
, Hiroshima J Med Sci, vol.59, pp.27-33, 2010.
The hallmarks of cancer, Cell, vol.100, pp.57-70, 2000. ,
p53 expression is 1558 common in malignant mesothelioma, Histopathology, vol.21, pp.331-334, 1992. ,
Immunoreactivity for p53 protein in 1560 malignant mesothelioma and non-neoplastic mesothelium, J Pathol, vol.168, pp.371-375, 1992. ,
, The Frequency of p53 Immunostaining in Asbestos-1562 Associated Mesotheliomas and Non-Asbestos-Associated Mesotheliomas
, Histopathology, vol.22, pp.383-386, 1993.
The use of immunohistochemistry in distinguishing 1565 reactive from neoplastic mesothelium. A novel use for desmin and comparative 1566 evaluation with epithelial membrane antigen, vol.53 ,
, Histopathology, vol.43, pp.231-238, 2003.
, Chapter ex15 new22Revised Vf(text and tables
Sensing centromere tension: Aurora B and the regulation 1578 of kinetochore function, Trends Cell Biol, vol.21, pp.133-140, 2011. ,
Long crocidolite asbestos fibers 1580 cause polyploidy by sterically blocking cytokinesis, Carcinogenesis, vol.17, pp.2013-2021, 1996. ,
Inhibition of cytokinesis by asbestos and synthetic fibres, Cell, vol.1582 ,
, Biol Intl, vol.23, pp.829-840, 1999.
Chrysotile effects on human lung cell carcinoma in 1584 culture: 3-D reconstruction and DNA quantification by image analysis ,
, Cancer, vol.8, p.181, 2008.
Particle-induced indentation of the alveolar 1587 epithelium caused by surface tension forces, J Appl Physiol, vol.109, pp.1179-1194, 2010. ,
Molecular and genetic changes in 1589 asbestos-related lung cancer, Cancer Lett, vol.265, pp.1-15, 2008. ,
Non-neoplastic and neoplastic pleural 1591 endpoints following fiber exposure, J Toxicol Environ Health B Crit Rev, vol.14, pp.153-1592, 2011. ,
Chromosomal translocations with specific breakpoints in 1594 asbestos-induced rat mesotheliomas, Cancer Res, vol.48, pp.6455-6461, 1988. ,
Analysis of K-ras and p53 1596 mutations in mesotheliomas from humans and rats exposed to asbestos ,
, Res, vol.468, pp.87-92, 2000.
P53 mutations in tumours 1599 induced by intraperitoneal injection of crocidolite asbestos and benzo ,
, Exp Toxicol Pathol, vol.49, pp.181-187, 1997.
Distinct spectrum of mutations induced by crocidolite 1602 asbestos : clue for 8-hydroxydeoxyguanosine-dependent mutagenesis in vivo ,
, Res, vol.62, pp.99-104, 2002.
Induction of 8-hydroxydeoxyguanosine by man 1605 made vitreous fibres and crocidolite asbestos administered intraperitoneally in rats ,
Activated TNF-alpha/NF-kappaB signaling via 1608 down-regulation of Fas-associated factor 1 in asbestos-induced mesotheliomas from Arf 1609 knockout mice, Proc Natl Acad Sci U S A, vol.106, pp.3420-3425, 2009. ,
Effects of asbestos on initiation of DNA 1611 damage, induction of DNA-strand breaks, P53-expression and apoptosis in primary, p.1612 ,
, SV40-transformed and malignant human mesothelial cells, Mutat Res, vol.558, pp.81-92, 2004.
Detection of 8-oxo-2'-deoxyguanosine, a marker 1614 of oxidative DNA damage, in culture medium from human mesothelial cells exposed to 1615 crocidolite asbestos, Carcinogen, vol.17, pp.2525-2527, 1996. ,
Patterns of 8-hydroxydeoxyguanosine 1617 formation in DNA and indications of oxidative stress in rat and human pleural mesothelial 1618 cells after exposure to crocidolite asbestos, Carcinogenesis, vol.18, pp.825-832, 1997. ,
DNA damage in bronchial epithelial and 1620 mesothelial cells with and without associated crocidolite asbestos fibers, Environ Mol, p.1621 ,
, Mutagen, vol.44, pp.477-482, 2004.
Chromosomal changes induced by 1623 chrysotile fibres or benzo(3-4)pyrene in rat pleural mesothelial cells ,
, Res, vol.169, pp.141-148, 1986.
Uncheduled DNA synthesis in rat pleural 1626 mesothelial cells treated with mineral fibres or benzo[a]pyrene, Mutat Res, vol.241, pp.361-1627, 1990. ,
Asbestos increases mammalian AP-1629 endonuclease gene expression, protein levels, and enzyme activity in mesothelial cells ,
, Cancer Res, vol.58, pp.189-194, 1998.
,
Asbestos-induced phosphorylation of 1638 epidermal growth actor receptor is linked to c-fos and apoptosis, Am J, p.1639 ,
, Physiol, vol.277, pp.684-693, 1999.
beta1-integrin mediates asbestos-induced phosphorylation 1641 of AKT and ERK1/2 in a rat pleural mesothelial cell line, Oncogene, vol.22, pp.8524-8528, 2003. ,
, Chapter ex15 new22Revised Vf(text and tables
, Figure 15-1. Multistage Development of Asbestos-Induced Mesothelioma
, , vol.76, 2003.
, , vol.253, 2008.
, , vol.114, 2010.
, , vol.254, 2011.
255] Rat, i.p. administration Chromosome analysis in MM. Crocidolite Chrysotile Loss of chromosomes X, 8, 16, Translocations involving 5, 10 and 13, vol.18, 1988. ,
, , p.256, 2000.
, Investigation of p53 (exons 5-8), and K-ras (exons 1, 2) mutations in MM
, Crocidolite No mutation detected
, , 1997.
, Rat, i.p. administration. Investigation of p53 mutations in MM
, Crocidolite No mutation detected in p53 while numerous base substitution were found in B
, , 2004.
, Big Blue rat, i.p. administration. Crocidolite Significantly enhanced mutation rate of lacI gene from omenta 12 and 24 weeks post-exposure*
, , 2004.
, Crocidolite Significantly enhanced level of 8-OHdG in DNA from omenta 10-20 weeks post treatment
, , 2002.
, , 2003.
, Mice, N?2 heterozygous, i.p. administration. Gene analysis. Crocidolite LOH at the N?2 locus
, , 2005.
, N?2 heterozygous, i.p. administration. Gene analysis. Crocidolite LOH at the N?2 locus. Deletion INK4 locus
, , 2005.
, , 2009.
, Arf heterozygous, i.p. administration. Gene analysis. Crocidolite LOH at the Arf locus. Hemizygous loss of Faf1 (Fas-associated factor 1)
, A to T (6%), A to G and insertion (3%), intraperitoneal LOH : Loss Of Heterozygozity * G to T predominant (29%) followed by deletion (26%), G to A (20%), G to C (12%)
, , 1989.
, Karyotype analysis (G banding)
, Crocidolite Chrysotile Amosite Non random aneuploidy, deletion, translocations, inversions (but not breaks, dicentrics, fragments, polyploidization)
, , vol.46, 1995.
, , 2004.
, Normal cells and human Met-5A
, DNA breakage (comet assay, quantification of DNA-strand breaks and Fpg-sensitive sites by alkaline unwinding*)
, Crocidolite Chrysotile DNA breakage in both assays, but no increase in Fpgsensitive sites. No effect on MeT-5A cells
, , 2004.
, , 1996.
Formation of 8-oxo-2'-deoxyguanosine released in the culture medium (HPLC) ,
, Crocidolite Increased level of of 8-oxo-2'-deoxyguanosine
MeT-5A. Formation of 8-OH-dG in DNA (HPLC), vol.263, 1997. ,
, Crocidolite Decreased level of 8-OH-dG
, , 1999.
High-resolution time-lapse microscopy. Crocidolite Chrysotile Delayed cytokinesis. Formation of bi-multinucleated cells ,
, , 2004.
, Crocidolite Increased DNA breakage, more pronounced in cells associated with fibers than in cells without fibers
Pleural mesothelial cells. Morphological study of metaphases. Chrysotile Increased chromosome breakage, vol.265, 1986. ,
URL : https://hal.archives-ouvertes.fr/inserm-02449474
Sister chromatid exchanges. Crocidolite Increased sister chromatid exchanges, vol.42, 1987. ,
Pleural mesothelial cells. Ultrastructural study of metaphases, vol.43, 1987. ,
, Crocidolite Chrysotile Polyploidization, chromosome deformities (vacuolization)
266] Pleural mesothelial cells. DNA repair (unscheluled DNA synthesis), 1990. ,
Pleural mesothelial cells. Morphological study of mitotic cells, vol.44, 1993. ,
Pleural mesothelial cells. DNA repair (unscheluled DNA synthesis), vol.40, 1994. ,
, Crocidolite Chrysotile Increased DNA repair. Partial involvement of ROS
41] Pleural mesothelial cells. DNA repair (poly(ADP-ribose) synthesis), 1995. ,
, Crocidolite Chrysotile Increased DNA repair. Partial involvement of ROS
Pleural mesothelial cells. Morphological study of mitotic cells, vol.47, 1995. ,
, Crocidolite Chrysotile Amosite Induction of abnormal anaphases and telophases
Pleural mesothelial cells. Formation of 8-OH-dG in DNA (HPLC) Crocidolite Increased level of 8-OH-dG, vol.263, 1997. ,
, , vol.34, 1997.
G0/G1 accumulation and timedependent p53 and p21 expression (chrysotile) ,
, , 1998.
, Pleural mesothelial cells, induction de l'enzyme apurinic/apyrimidinic endonuclease
, Crocidolite Increased level (mRNA and protein)
Cell cyle arrest in G2/M. Phagocytosis reduction by cytochalasin reduces DNA breakage ,
, Met-5A : an SV40-transformed human mesothelial cell line
, ROS : Reactive Oxygen Species * Fpg protein, which recognizes oxidized bases such as 8-oxo-guanine, is used as indicative of oxidative DNA-base modifications
, Reduction of micronucleus formation by antioxidants (metal chelators and ROS scavengers). ROS produced by fibers (crocidolite), 1994.
, Pleural mesothelial cells from rat
, Crocidolite Chrysotile Increased mRNA expression of c-fos and c-jun
, , 1998.
, Pleural mesothelial cells from rat. Crocidolite Increased mRNA and protein expression of c-fos and c-jun
, , 1999.
, Crocidolite Increased expression of mRNA c-fos via enhancement of EGFR level
, , 2003.
, , 2009.
, Crocidolite Regulation of NF-?B dependent on Faf1 expression in response to TNF-?. Upregulated in cell showing loss of Faf1 (see Table, pp.22-23
, Met-5A : a SV40-transformed human mesothelial cell line