 |
Journal articles
Specific inhibition of DNMT1/CFP1 reduces cancer phenotypes and enhances chemotherapy effectiveness
Pierre-Francois Cartron
1
Mathilde Cheray
1
Arulraj Nadaradjane
1
Pascal Bonnet
2
Sylvain Routier
2
François Vallette
1
Pierre-François Cartron
1
1
CRCINA-ÉQUIPE 9 - Apoptosis and Tumor Progression
CRCINA - Centre de Recherche en Cancérologie et Immunologie Nantes-Angers
Pierre-Francois Cartron 1
Mail :
Author IdHAL : pierre-francois-cartron ORCID : https://orcid.org/0000-0002-3393-784X
Mathilde Cheray 1
Mail :
Author
Arulraj Nadaradjane 1
Mail :
Author
Pascal Bonnet 2
Mail :
Author
Sylvain Routier 2
Author
François M. Vallette 1
Mail :
Author
Pierre-François Cartron 1
Mail :
Author IdHAL : pierre-francois-cartron ORCID : https://orcid.org/0000-0002-3393-784X
1
CRCINA-ÉQUIPE 9 - Apoptosis and Tumor Progression (Institut de Recherche en Santé de l'Université de Nantes - 8 quai Moncousu - BP 70721 - 44007 Nantes cedex 1 - France)
- CRCINA - Centre de Recherche en Cancérologie et Immunologie Nantes-Angers (8 quai de Moncousu - BP 70721 - 44007 Nantes Cedex 1 - France)
- INSERM - Institut National de la Santé et de la Recherche Médicale : UMR1232 (101, rue de Tolbiac, 75013 Paris - France)
- UFR MEDECINE - Université de Nantes - UFR de Médecine et des Techniques Médicales : UMR1232 (1 rue Gaston Veil BP 53508 44035 NANTES Cedex 1 - France)
- UN - Université de Nantes (1, quai de Tourville - BP 13522 - 44035 Nantes cedex 1 - France)
- CHU Nantes - Centre hospitalier universitaire de Nantes : UMR1232 (1 Place Alexis-Ricordeau, 44000 Nantes - France)
- CNRS - Centre National de la Recherche Scientifique : ERL6001 (France)
- UA - Université d'Angers : UMR1232 (Université d'Angers - 40 Rue de Rennes, BP 73532 - 49035 Angers CEDEX 01 - France)
2
ICOA - Institut de Chimie Organique et Analytique (UFR Sciences Rue de Chartres - BP 6759 45067 ORLEANS CEDEX 2 - France)
- CEA - Commissariat à l'énergie atomique et aux énergies alternatives : UMR 7311 (Centre de Saclay Centre de Grenoble Centre de Cadarache etc - France)
- UO - Université d'Orléans : UMR 7311 (Château de la Source - Avenue du Parc Floral - BP 6749 - 45067 Orléans cedex 2 - France)
- INSERM - Institut National de la Santé et de la Recherche Médicale : UMR 7311 (101, rue de Tolbiac, 75013 Paris - France)
- CNRS - Centre National de la Recherche Scientifique : UMR 7311 (France)
Abstract : Aim: DNA methylation is a fundamental biologic process of genomes and is a candidate for pharmacological manipulation that might have important therapeutic advantages. Thus, DNA methyltransferases (DNMTs) appear to be ideal targets for drug intervention. Materials & methods: To develop a new generation of DNMT inhibitor, we analyzed the ability of peptides to selectively inhibit certain DNMT1-incuding complexes. Results: Our study demonstrates that the disruption of DNMT1/CFP1-including complexes increases the efficiency of chemotherapeutic treatment on established tumors in mice. Conclusion: Our data opens a promising and innovative alternative to the development of DNMT inhibitors
Document type :
Journal articles
Complete list of metadatas
https://www.hal.inserm.fr/inserm-02478615
Contributor : Pierre-Francois Cartron <>
Submitted on : Friday, February 14, 2020 - 6:21:37 AM
Last modification on : Friday, June 19, 2020 - 3:25:00 AM
Contributor : Pierre-Francois Cartron <>
Submitted on : Friday, February 14, 2020 - 6:21:37 AM
Last modification on : Friday, June 19, 2020 - 3:25:00 AM
Identifiers
- HAL Id : inserm-02478615, version 1
- DOI : 10.2217/epi.14.18
Collections
ICOA | CEA | UNIV-ORLEANS | UNIV-NANTES | CNRS | CRCINA | UNIV-ANGERS
Citation
Pierre-Francois Cartron, Mathilde Cheray, Arulraj Nadaradjane, Pascal Bonnet, Sylvain Routier, et al.. Specific inhibition of DNMT1/CFP1 reduces cancer phenotypes and enhances chemotherapy effectiveness. Epigenomics, Future Medicine, 2014, 6 (3), pp.267-275. ⟨10.2217/epi.14.18⟩. ⟨inserm-02478615⟩
Metrics
Record views
