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Specific inhibition of DNMT1/CFP1 reduces cancer phenotypes and enhances chemotherapy effectiveness

Pierre-Francois Cartron 1 Mathilde Cheray 1 Arulraj Nadaradjane 1 Pascal Bonnet 2 Sylvain Routier 2 François Vallette 1 Pierre-François Cartron 1
1 CRCNA / Equipe 9 - Apoptose et Progression tumorale
IRS-UN - Institut de Recherche en Santé de l'Université de Nantes, INSERM - Institut National de la Santé et de la Recherche Médicale : U892
2 ICOA - Institut de Chimie Organique et Analytique
Abstract : Aim: DNA methylation is a fundamental biologic process of genomes and is a candidate for pharmacological manipulation that might have important therapeutic advantages. Thus, DNA methyltransferases (DNMTs) appear to be ideal targets for drug intervention. Materials & methods: To develop a new generation of DNMT inhibitor, we analyzed the ability of peptides to selectively inhibit certain DNMT1-incuding complexes. Results: Our study demonstrates that the disruption of DNMT1/CFP1-including complexes increases the efficiency of chemotherapeutic treatment on established tumors in mice. Conclusion: Our data opens a promising and innovative alternative to the development of DNMT inhibitors
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Journal articles
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https://www.hal.inserm.fr/inserm-02478615
Contributor : Pierre-Francois Cartron <>
Submitted on : Friday, February 14, 2020 - 6:21:37 AM
Last modification on : Saturday, February 15, 2020 - 1:36:40 AM

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Pierre-Francois Cartron, Mathilde Cheray, Arulraj Nadaradjane, Pascal Bonnet, Sylvain Routier, et al.. Specific inhibition of DNMT1/CFP1 reduces cancer phenotypes and enhances chemotherapy effectiveness. Epigenomics, Future Medicine, 2014, 6 (3), pp.267-275. ⟨10.2217/epi.14.18⟩. ⟨inserm-02478615⟩

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