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Journal articles
Specific inhibition of DNMT1/CFP1 reduces cancer phenotypes and enhances chemotherapy effectiveness
Abstract : Aim: DNA methylation is a fundamental biologic process of genomes and is a candidate for pharmacological manipulation that might have important therapeutic advantages. Thus, DNA methyltransferases (DNMTs) appear to be ideal targets for drug intervention. Materials & methods: To develop a new generation of DNMT inhibitor, we analyzed the ability of peptides to selectively inhibit certain DNMT1-incuding complexes. Results: Our study demonstrates that the disruption of DNMT1/CFP1-including complexes increases the efficiency of chemotherapeutic treatment on established tumors in mice. Conclusion: Our data opens a promising and innovative alternative to the development of DNMT inhibitors
https://www.hal.inserm.fr/inserm-02478615
Contributor : Pierre-Francois Cartron Connect in order to contact the contributor
Submitted on : Friday, February 14, 2020 - 6:21:37 AM
Last modification on : Wednesday, October 20, 2021 - 3:19:36 AM
Contributor : Pierre-Francois Cartron Connect in order to contact the contributor
Submitted on : Friday, February 14, 2020 - 6:21:37 AM
Last modification on : Wednesday, October 20, 2021 - 3:19:36 AM