M. F. Holick, Vitamin D deficiency, N Engl J Med, vol.357, pp.266-81, 2007.

P. Autier, P. Mullie, A. Macacu, M. Dragomir, M. Boniol et al., Effect of vitamin D supplementation on non-skeletal disorders: a systematic review of metaanalyses and randomised trials, Lancet Diabetes Endocrinol, vol.5, pp.30357-30358, 2017.

A. Giustina, R. A. Adler, N. Binkley, R. Bouillon, P. R. Ebeling et al., Controversies in vitamin D: summary statement from an international conference, J Clin Endocrinol Metab, vol.104, pp.234-274, 2019.

J. E. Manson, N. R. Cook, I. Lee, C. W. Bassuk, S. S. Mora et al., Vitamin D supplements and prevention of cancer and cardiovascular disease, N Engl J Med, vol.380, pp.33-44, 2019.

K. Ng, H. S. Nimeiri, N. J. Mccleary, T. A. Abrams, M. B. Yurgelun et al., Effect of high-dose vs standard-dose vitamin D3 supplementation on progression-free survival among patients with advanced or metastatic colorectal cancer: the sunshine randomized clinical trial, JAMA, vol.321, pp.1370-1379, 2019.

A. Gugger, A. Marzel, E. J. Orav, W. C. Willett, B. Dawson-hughes et al., Effect of monthly high-dose vitamin D on mental health in older adults: secondary analysis of a RCT, J Am Geriatr Soc, vol.67, pp.1211-1218, 2019.

K. Silvis, C. A. Aronsson, X. Liu, U. Uusitalo, J. Yang et al., Maternal dietary supplement use and development of islet autoimmunity in the offspring: TEDDY study, Pediatr Diabetes, vol.20, pp.86-92, 2019.

C. Bizzarri, D. Pitocco, N. Napoli, D. Stasio, E. et al., No protective effect of calcitriol on beta-cell function in recent-onset type 1 diabetes: the IMDIAB XIII trial, Diabetes Care, vol.33, pp.1962-1965, 2010.

A. A. Quyyumi, A. Mheid, and I. , The demise of vitamin D for cardiovascular prevention, JAMA Cardiol, 2019.

E. L. Barry, M. N. Passarelli, and J. A. Baron, Vitamin D as cancer therapy?: Insights from 2 new trials, JAMA, vol.321, pp.1354-1359, 2019.

J. J. Mcgrath, Vitamin D and mental health -the scrutiny of science delivers a sober message, Acta Psychiatr Scand, vol.135, pp.183-187, 2017.

R. Jorde and J. Kubiak, No improvement in depressive symptoms by vitamin D supplementation: results from a randomised controlled trial, J Nutr Sci, vol.7, 2018.

J. Maddock, A. Zhou, A. Cavadino, E. Ku?ma, Y. Bao et al., Vitamin D and cognitive function: a Mendelian randomisation study, Sci Rep, vol.7, p.13230, 2017.

L. Rejnmark, L. S. Bislev, K. D. Cashman, G. Eiríksdottir, M. Gaksch et al., Non-skeletal health effects of vitamin D supplementation: a systematic review on findings from meta-analyses summarizing trial data, PLoS One, vol.12, 2017.

J. M. Lappe and R. P. Heaney, Why randomized controlled trials of calcium and vitamin D sometimes fail, Dermato Endocrinol, vol.4, pp.95-100, 2012.

W. B. Grant, B. J. Boucher, H. P. Bhattoa, and H. Lahore, Why vitamin D clinical trials should be based on 25-hydroxyvitamin D concentrations, J Steroid Biochem Mol Biol, vol.177, pp.266-275, 2018.

R. Jorde, RCTS are the only appropriate way to demonstrate the role of vitamin D in health, J Steroid Biochem Mol Biol, vol.177, pp.10-14, 2018.

R. Scragg, Limitations of vitamin D supplementation trials: Why observational studies will continue to help determine the role of vitamin D in health, J Steroid Biochem Mol Biol, vol.177, pp.6-9, 2018.

T. Kuhn, The structure of scientific revolutions, 1962.

M. F. Holick, Vitamin D status: measurement, interpretation, and clinical application

, Ann Epidemiol, vol.19, pp.73-81, 2009.

R. W. Chesney, J. F. Rosen, A. J. Hamstra, C. Smith, K. Mahaffey et al., Absence of seasonal variation in serum concentrations of 1,25-dihydroxyvitamin D despite a rise in 25-hydroxyvitamin D in summer, J Clin Endocrinol Metab, vol.53, pp.139-181, 1981.

T. J. Hine and N. B. Roberts, Seasonal variation in serum 25-hydroxy vitamin D3 does not affect 1,25-dihydroxy vitamin D, Ann Clin Biochem, vol.31, pp.31-35, 1994.

R. M. Biancuzzo, N. Clarke, R. E. Reitz, T. G. Travison, and M. F. Holick, Serum concentrations of 1,25-dihydroxyvitamin D2 and 1,25-dihydroxyvitamin D3 in response to vitamin D2 and vitamin D3 supplementation, J Clin Endocrinol Metab, vol.98, pp.973-982, 2013.

A. Zittermann, J. B. Ernst, I. Birschmann, and M. Dittrich, Effect of vitamin D or activated vitamin D on circulating 1,25-dihydroxyvitamin D concentrations: a systematic review and metaanalysis of randomized controlled trials, Clin Chem, vol.61, pp.1484-94, 2015.

K. Hesselink and J. M. , Fundamentals of and critical issues in lipid autacoid medicine: a review, Pain Ther, vol.6, pp.153-64, 2017.

C. N. Serhan and B. D. Levy, Resolvins in inflammation: emergence of the pro-resolving superfamily of mediators, J Clin Invest, 2018.

B. W. Hollis and C. L. Wagner, Clinical review: the role of the parent compound vitamin D with respect to metabolism and function: why clinical dose intervals can affect clinical outcomes, J Clin Endocrinol Metab, vol.98, pp.4619-4647, 2013.

R. Bouillon, M. Garmyn, A. Verstuyf, S. Segaert, K. Casteels et al., Paracrine role for calcitriol in the immune system and skin creates new therapeutic possibilities for vitamin D analogs, Eur J Endocrinol, vol.133, pp.7-16, 1995.

M. Ellfolk, M. Norlin, K. Gyllensten, and K. Wikvall, Regulation of human vitamin D(3) 25-hydroxylases in dermal fibroblasts and prostate cancer LNCaP cells, Mol Pharmacol, vol.75, pp.1392-1401, 2009.

L. Bonnet, M. A. Hachemi, E. Karkeni, C. Couturier, J. Astier et al., Diet induced obesity modifies vitamin D metabolism and adipose tissue storage in mice
URL : https://hal.archives-ouvertes.fr/hal-01998526

, J Steroid Biochem Mol Biol, vol.185, pp.39-46, 2019.

V. Landel, D. Stephan, X. Cui, D. Eyles, and F. Feron, Differential expression of vitamin Dassociated enzymes and receptors in brain cell subtypes, J Steroid Biochem Mol Biol, vol.177, pp.129-163, 2018.
URL : https://hal.archives-ouvertes.fr/hal-01735376

D. Zehnder, R. Bland, M. C. Williams, R. W. Mcninch, A. J. Howie et al., Extrarenal expression of 25-hydroxyvitamin d(3)-1 alpha-hydroxylase, J Clin Endocrinol Metab, vol.86, pp.888-94, 2001.

M. Hewison, Vitamin D and immune function: autocrine, paracrine or endocrine?, Scand J Clin Lab Invest Suppl, vol.243, pp.92-102, 2012.

D. Feldman, A. V. Krishnan, S. Swami, E. Giovannucci, and B. J. Feldman, The role of vitamin D in reducing cancer risk and progression, Nat Rev Cancer, vol.14, pp.342-57, 2014.

M. El-atifi, M. Dreyfus, F. Berger, and D. Wion, Expression of CYP2R1 and VDR in human brain pericytes: the neurovascular vitamin D autocrine/paracrine model, NeuroReport, vol.26, pp.245-253, 2015.
URL : https://hal.archives-ouvertes.fr/inserm-01342467

M. Dreyfus and D. Wion, Investigating the relationship between vitamin D and cancer requires dosing the bioavailable nonhydroxylated vitamin D storage in cancer tissues, Cancer, vol.121, pp.3362-3365, 2015.
URL : https://hal.archives-ouvertes.fr/inserm-01194476

E. B. Mawer, J. Backhouse, C. A. Holman, G. A. Lumb, and S. W. Stanbury, The distribution and storage of vitamin D and its metabolites in human tissues, Clin Sci, vol.43, pp.413-444, 1972.

X. Fu, G. G. Dolnikowski, W. B. Patterson, B. Dawson-hughes, T. Zheng et al., Determination of vitamin D and Its metabolites in human brain using an ultrapressure LC-tandem mass spectra method, Curr Dev Nutr, vol.3, 2019.

S. Safaiyan, N. Kannaiyan, N. Snaidero, S. Brioschi, K. Biber et al., Age-related myelin degradation burdens the clearance function of microglia during aging, Nat Neurosci, vol.19, pp.995-1003, 2016.

I. Neveu, P. Naveilhan, C. Menaa, D. Wion, P. Brachet et al., Synthesis of 1,25-dihydroxyvitamin D3 by rat brain macrophages in vitro, J Neurosci Res, vol.38, pp.214-234, 1994.
URL : https://hal.archives-ouvertes.fr/inserm-02276158

M. Yeung, S. Zdunek, O. Bergmann, S. Bernard, M. Salehpour et al., Dynamics of oligodendrocyte generation and myelination in the human brain, Cell, vol.159, pp.766-74, 2014.
URL : https://hal.archives-ouvertes.fr/hal-01092151

X. Cui, H. Gooch, A. Petty, J. J. Mcgrath, and D. Eyles, Vitamin D and the brain: genomic and non-genomic actions, Mol Cell Endocrinol, vol.453, pp.131-174, 2017.

E. Garcion, N. Wion-barbot, C. N. Montero-menei, F. Berger, and D. Wion, New clues about vitamin D functions in the nervous system, Trends Endocrinol Metab, vol.13, pp.100-105, 2002.

M. Lu, B. V. Taylor, and H. Körner, Genomic effects of the vitamin D receptor: potentially the link between vitamin D, immune cells, and multiple sclerosis, Front Immunol, vol.9, p.477, 2018.