Skip to Main content Skip to Navigation
Journal articles

Defective Excitation-Contraction Coupling in Experimental Cardiac Hypertrophy and Heart Failure

Abstract : Cardiac hypertrophy and heart failure caused by high blood pressure were studied in single myocytes taken from hypertensive rats (Dahl SS/Jr) and SH-HF rats in heart failure. Confocal microscopy and patch-clamp methods were used to examine excitation-contraction (EC) coupling, and the relation between the plasma membrane calcium current (ICa) and evoked calcium release from the sarcoplasmic reticulum (SR), which was visualized as "calcium sparks." The ability of ICa to trigger calcium release from the SR in both hypertrophied and failing hearts was reduced. Because ICa density and SR calcium-release channels were normal, the defect appears to reside in a change in the relation between SR calcium-release channels and sarcolemmal calcium channels. beta-Adrenergic stimulation largely overcame the defect in hypertrophic but not failing heart cells. Thus, the same defect in EC coupling that develops during hypertrophy may contribute to heart failure when compensatory mechanisms fail.
Complete list of metadata

Cited literature [75 references]  Display  Hide  Download
Contributor : Ana Maria Gomez Connect in order to contact the contributor
Submitted on : Thursday, February 13, 2020 - 2:01:54 PM
Last modification on : Monday, May 9, 2022 - 11:58:07 AM
Long-term archiving on: : Thursday, May 14, 2020 - 3:32:08 PM


 Restricted access
To satisfy the distribution rights of the publisher, the document is embargoed until : jamais

Please log in to resquest access to the document




Ana Maria Gómez, H H Valdivia, H Cheng, M R Lederer, L F Santana, et al.. Defective Excitation-Contraction Coupling in Experimental Cardiac Hypertrophy and Heart Failure. Science, American Association for the Advancement of Science (AAAS), 1997, 276 (5313), pp.800-806. ⟨10.1126/science.276.5313.800⟩. ⟨inserm-02477489⟩



Record views