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Ability of clionasterol and poriferasterol (24-epimers of sitosterol and stigmasterol) to regulate membrane lipid dynamics

Abstract : Stigmasterol and sitosterol, which are the major sterols contained in plasma membranes of plant cells have been shown to possess a different ordering ability: stigmasterol is less efficient than sitosterol for regulating membrane permeability and fluidity. We have evaluated the activity of their C-24 epimers on model membranes systems by 2H-NMR. Clionasterol was found to be as efficient as sitosterol; in contrast, poriferasterol appeared to be less efficient than its epimer, stigmasterol. The modification of the configuration at C-24 has thus an influence on the sterol ordering ability in the case of a coexistence of the Δ12 double bond and the ethyl group, i.e. in the stigmasterol series.
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Submitted on : Wednesday, February 12, 2020 - 9:17:24 AM
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Mary-Pierre Marsan, Isabelle Müller, Alain Milon. Ability of clionasterol and poriferasterol (24-epimers of sitosterol and stigmasterol) to regulate membrane lipid dynamics. Chemistry and Physics of Lipids, Elsevier, 1996, 84 (2), pp.117-121. ⟨10.1016/S0009-3084(96)02628-X⟩. ⟨inserm-02475422⟩

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