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FcγRIII discriminates between 2 subsets of Vγ9Vδ2 effector cells with different responses and activation pathways

Abstract : Upon recognition of nonpeptidic phosphoantigens, human Vdelta2 T lymphocytes enter a lineage differentiation pattern that determines the generation of memory cells with a range of effector functions. Here, we show that within the effector memory Vdelta2 population, 2 distinct and complementary subsets with regard to phenotype, mode of activation, and type of responses can be identified: Vdelta2 T(EMh) cells, which express high levels of chemokine receptors, but low levels of perforin and of natural killer receptors (NKRs) and which produce large amounts of interferon gamma (IFN-gamma) and tumor necrosis factor alpha (TNF-alpha) in response to T-cell receptor (TCR)-specific stimulation by phosphoantigens; and Vdelta2T(EMRA) cells, which constitutively express several NKRs, high amounts of perforin, but low levels of chemokine receptors and of IFN-gamma. These NK-like cells are refractory to phosphoantigen but respond to activation via FcgammaRIII (CD16) and are highly active against tumoral target cells. Thus, circulating Vdelta2T lymphocytes comprise 2 functionally diverse subsets of effector memory cells that may be discriminated on the basis of CD16 expression.
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https://www.hal.inserm.fr/inserm-02472274
Contributor : Mary Poupot <>
Submitted on : Monday, February 10, 2020 - 10:14:17 AM
Last modification on : Monday, June 29, 2020 - 2:18:02 PM

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Daniela Angelini, Giovanna Borsellino, Mary Poupot, Adamo Diamantini, Rémy Poupot, et al.. FcγRIII discriminates between 2 subsets of Vγ9Vδ2 effector cells with different responses and activation pathways. Blood, American Society of Hematology, 2004, 104 (6), pp.1801-1807. ⟨10.1182/blood-2004-01-0331⟩. ⟨inserm-02472274⟩

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