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Journal articles
A Phosphorus-Based Dendrimer Targets Inflammation and Osteoclastogenesis in Experimental Arthritis
Myriam Hayder
1
Mary Poupot
2
M. Baron
1
D. Nigon
3
A.-M. Caminade
4
Jean Pierre Majoral
4
Cédric-Olivier Turrin
4
R. Eisenberg
5
Jean-Jacques Fournie
2
Alain Cantagrel
1
Rémy Poupot
1
Jean-Luc Davignon
1
A.-M. Caminade 4
Author IdHAL : anne-marie-caminade ResearcherId : http://www.researcherid.com/rid/E-2819-2015 ORCID : https://orcid.org/0000-0001-8487-3578
Jean Pierre Majoral 4
Author
Cédric-Olivier Turrin 4
Author IdHAL : cedric-olivier-turrin ORCID : https://orcid.org/0000-0001-7187-8070
R. Eisenberg 5
Author
Jean-Jacques Fournie 2
Author IdHAL : jean-jacques-fournie
Alain Cantagrel 1
Author Employer institution : Université Toulouse III - Paul Sabatier
Rémy Poupot 1
Author Employer institution : Université Toulouse III - Paul Sabatier
Jean-Luc Davignon 1
Author
1
CPTP - Centre de Physiopathologie Toulouse Purpan (Hôpital de Purpan Place du Docteur Baylac 31024 TOULOUSE CEDEX 3 - France)
- UT3 - Université Toulouse III - Paul Sabatier (118 route de Narbonne - 31062 Toulouse - France)
- Université Fédérale Toulouse Midi-Pyrénées (41 Allée Jules Guesde, 31000 Toulouse - France)
- INSERM - Institut National de la Santé et de la Recherche Médicale : U1043 (101, rue de Tolbiac, 75013 Paris - France)
- CNRS - Centre National de la Recherche Scientifique : UMR5282 (France)
2
CRCT - Centre de Recherches en Cancérologie de Toulouse (Centre de Recherches en Cancérologie de Toulouse
2 Avenue Hubert Curien
31037 Toulouse Cedex 1
FRANCE - France)
- CNRS - Centre National de la Recherche Scientifique : ERL5294 (France)
- UT3 - Université Toulouse III - Paul Sabatier (118 route de Narbonne - 31062 Toulouse - France)
- Université Fédérale Toulouse Midi-Pyrénées (41 Allée Jules Guesde, 31000 Toulouse - France)
- INSERM - Institut National de la Santé et de la Recherche Médicale : U1037 (101, rue de Tolbiac, 75013 Paris - France)
3
Centre de Rhumatologie toulouse [CHU Toulouse] (France)
- CHU Toulouse [Toulouse] (Hôtel-Dieu Saint Jacques 2, rue Viguerie TSA 80035 31059 Toulouse cedex 9 - France)
- Hôpital Purpan [Toulouse] (Place du Docteur Baylac
TSA 40031
31059 Toulouse cedex 9 - France)
- CHU Toulouse [Toulouse] (Hôtel-Dieu Saint Jacques 2, rue Viguerie TSA 80035 31059 Toulouse cedex 9 - France)
4
LCC - Laboratoire de chimie de coordination (205 Route de Narbonne 31077 TOULOUSE CEDEX 4 - France)
- Toulouse INP - Institut National Polytechnique (Toulouse) (France)
- Université Fédérale Toulouse Midi-Pyrénées (41 Allée Jules Guesde, 31000 Toulouse - France)
- UT3 - Université Toulouse III - Paul Sabatier (118 route de Narbonne - 31062 Toulouse - France)
- Université Fédérale Toulouse Midi-Pyrénées (41 Allée Jules Guesde, 31000 Toulouse - France)
- ICT-FR 2599 - Institut de Chimie de Toulouse (118 Route de Narbonne 31062 Toulouse cédex 9 - France)
- CNRS - Centre National de la Recherche Scientifique : UAR2599 / FR2599 (France)
- UT3 - Université Toulouse III - Paul Sabatier (118 route de Narbonne - 31062 Toulouse - France)
- Université Fédérale Toulouse Midi-Pyrénées (41 Allée Jules Guesde, 31000 Toulouse - France)
- IRD - Institut de Recherche pour le Développement (Siège Le Sextant 44, bd de Dunkerque CS 90009 13572 Marseille cedex 02 - France)
- Toulouse INP - Institut National Polytechnique (Toulouse) (France)
- Université Fédérale Toulouse Midi-Pyrénées (41 Allée Jules Guesde, 31000 Toulouse - France)
- INC - Institut de Chimie du CNRS (3 Rue Michel-Ange 75 016 Paris - France)
- CNRS - Centre National de la Recherche Scientifique : UPR8241 (France)
5
Department of Medicine - Division of Rheumatology [Philadelphia, PA, USA] (United States)
- University of Pennsylvania [Philadelphia] (3451 Walnut Street, Philadelphia, PA 19104 | 215-898-5000 - United States)
Abstract : Dendrimers are highly branched "tree-like" polymers that have demonstrated therapeutic potential in drug delivery, medical imaging, and tissue engineering in recent years. In addition, we have shown that an azabisphosphonate (ABP)-capped dendrimer selectively targets monocytes and directs them toward anti-inflammatory activation. We explored this property to assess the therapeutic potential of dendrimer ABP in the treatment of an inflammatory disease, rheumatoid arthritis. Intravenous injections of dendrimer ABP inhibited the development of inflammatory arthritis in two animal models: IL-1ra(-/-) mice and mice undergoing K/BxN serum transfer. Suppression of disease was characterized by normal synovial membranes, reduced levels of inflammatory cytokines, and the absence of cartilage destruction and bone erosion. Dendrimer ABP also exhibited anti-osteoclastic activity on mouse and human cells, mediated by c-FMS (cellular-feline McDonough strain sarcoma virus oncogene homolog) inhibition. These preclinical demonstrations suggest the potential use of dendrimer ABP as a nanotherapeutic for rheumatoid arthritis.
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Journal articles
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https://www.hal.inserm.fr/inserm-02472244
Contributor : Mary Poupot Connect in order to contact the contributor
Submitted on : Monday, February 10, 2020 - 10:03:33 AM
Last modification on : Thursday, December 2, 2021 - 2:10:04 PM
Contributor : Mary Poupot Connect in order to contact the contributor
Submitted on : Monday, February 10, 2020 - 10:03:33 AM
Last modification on : Thursday, December 2, 2021 - 2:10:04 PM
Identifiers
- HAL Id : inserm-02472244, version 1
- DOI : 10.1126/scitranslmed.3002212
- PUBMED : 21543721
Citation
Myriam Hayder, Mary Poupot, M. Baron, D. Nigon, A.-M. Caminade, et al.. A Phosphorus-Based Dendrimer Targets Inflammation and Osteoclastogenesis in Experimental Arthritis. Science Translational Medicine, American Association for the Advancement of Science, 2011, 3 (81), pp.81ra35-81ra35. ⟨10.1126/scitranslmed.3002212⟩. ⟨inserm-02472244⟩
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