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A Phosphorus-Based Dendrimer Targets Inflammation and Osteoclastogenesis in Experimental Arthritis
M. Hayder
1
M. Poupot
2
M. Baron
1
D. Nigon
3
C.-O. Turrin
4
A.-M. Caminade
4
J.-P. Majoral
4
R. Eisenberg
5
J.-J. Fournie
2
A. Cantagrel
1
R. Poupot
1
J.-L. Davignon
1
1
CPTP - U1043 INSERM - UMR5282 CNRS - UT3 - Centre de Physiopathologie Toulouse Purpan (France)
- UT3 - Université Toulouse III - Paul Sabatier (118 route de Narbonne - 31062 Toulouse - France)
- Université Fédérale Toulouse Midi-Pyrénées (41 Allée Jules Guesde, 31000 Toulouse - France)
- INSERM - Institut National de la Santé et de la Recherche Médicale : U1043 (101, rue de Tolbiac, 75013 Paris - France)
- CNRS - Centre National de la Recherche Scientifique : UMR5282 (France)
2
CRCT - Centre de Recherches en Cancérologie de Toulouse (Centre de Recherches en Cancérologie de Toulouse
2 Avenue Hubert Curien
31037 Toulouse Cedex 1
FRANCE - France)
- UT3 - Université Toulouse III - Paul Sabatier (118 route de Narbonne - 31062 Toulouse - France)
- Université Fédérale Toulouse Midi-Pyrénées (41 Allée Jules Guesde, 31000 Toulouse - France)
- INSERM - Institut National de la Santé et de la Recherche Médicale : U1037 (101, rue de Tolbiac, 75013 Paris - France)
- CNRS - Centre National de la Recherche Scientifique : ERL5294 (France)
3
Centre de Rhumatologie toulouse [CHU Toulouse] (France)
- Hôpital Purpan [Toulouse] (Place du Docteur Baylac
TSA 40031
31059 Toulouse cedex 9 - France)
- CHU Toulouse [Toulouse] (Hôtel-Dieu Saint Jacques 2, rue Viguerie TSA 80035 31059 Toulouse cedex 9 - France)
- CHU Toulouse - Centre Hospitalier Universitaire de Toulouse (France)
4
LCC - Laboratoire de chimie de coordination (205 Route de Narbonne 31077 TOULOUSE CEDEX 4 - France)
- Toulouse INP - Institut National Polytechnique (Toulouse) (France)
- Université Fédérale Toulouse Midi-Pyrénées (41 Allée Jules Guesde, 31000 Toulouse - France)
- UT3 - Université Toulouse III - Paul Sabatier (118 route de Narbonne - 31062 Toulouse - France)
- Université Fédérale Toulouse Midi-Pyrénées (41 Allée Jules Guesde, 31000 Toulouse - France)
- ICT-FR 2599 - Institut de Chimie de Toulouse (118 Route de Narbonne 31062 Toulouse cédex 9 - France)
- Toulouse INP - Institut National Polytechnique (Toulouse) (France)
- Université Fédérale Toulouse Midi-Pyrénées (41 Allée Jules Guesde, 31000 Toulouse - France)
- IRD - Institut de Recherche pour le Développement (Siège Le Sextant 44, bd de Dunkerque CS 90009 13572 Marseille cedex 02 - France)
- UT3 - Université Toulouse III - Paul Sabatier (118 route de Narbonne - 31062 Toulouse - France)
- Université Fédérale Toulouse Midi-Pyrénées (41 Allée Jules Guesde, 31000 Toulouse - France)
- CNRS - Centre National de la Recherche Scientifique : FR2599 (France)
- Toulouse INP - Institut National Polytechnique (Toulouse) (France)
- CNRS - Centre National de la Recherche Scientifique : UPR8241 (France)
5
Department of Medicine - Division of Rheumatology [Philadelphia, PA, USA] (United States)
- University of Pennsylvania [Philadelphia] (3451 Walnut Street, Philadelphia, PA 19104 | 215-898-5000 - United States)
Abstract : Dendrimers are highly branched "tree-like" polymers that have demonstrated therapeutic potential in drug delivery, medical imaging, and tissue engineering in recent years. In addition, we have shown that an azabisphosphonate (ABP)-capped dendrimer selectively targets monocytes and directs them toward anti-inflammatory activation. We explored this property to assess the therapeutic potential of dendrimer ABP in the treatment of an inflammatory disease, rheumatoid arthritis. Intravenous injections of dendrimer ABP inhibited the development of inflammatory arthritis in two animal models: IL-1ra(-/-) mice and mice undergoing K/BxN serum transfer. Suppression of disease was characterized by normal synovial membranes, reduced levels of inflammatory cytokines, and the absence of cartilage destruction and bone erosion. Dendrimer ABP also exhibited anti-osteoclastic activity on mouse and human cells, mediated by c-FMS (cellular-feline McDonough strain sarcoma virus oncogene homolog) inhibition. These preclinical demonstrations suggest the potential use of dendrimer ABP as a nanotherapeutic for rheumatoid arthritis.
Document type :
Journal articles
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Complete list of metadatas
https://www.hal.inserm.fr/inserm-02472244
Contributor : Mary Poupot <>
Submitted on : Monday, February 10, 2020 - 10:03:33 AM
Last modification on : Wednesday, March 18, 2020 - 11:24:02 AM
Contributor : Mary Poupot <>
Submitted on : Monday, February 10, 2020 - 10:03:33 AM
Last modification on : Wednesday, March 18, 2020 - 11:24:02 AM
Identifiers
- HAL Id : inserm-02472244, version 1
- DOI : 10.1126/scitranslmed.3002212
- PUBMED : 21543721
Collections
UNIV-TLSE3 | INC-CNRS | CNRS
Citation
M. Hayder, M. Poupot, M. Baron, D. Nigon, C.-O. Turrin, et al.. A Phosphorus-Based Dendrimer Targets Inflammation and Osteoclastogenesis in Experimental Arthritis. Science Translational Medicine, American Association for the Advancement of Science, 2011, 3 (81), pp.81ra35-81ra35. ⟨10.1126/scitranslmed.3002212⟩. ⟨inserm-02472244⟩
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