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Journal articles
The PPARα pathway in Vγ9Vδ2 T cell anergy
Mary Poupot
1
Frédéric Boissard
1
Delphine Bétous
1
Laure Bardouillet
Séverine Fruchon
2
Fatima L’faqihi-Olive
Frédéric Pont
1
Mourad Mekaouche
3
Sophie Ingoure
Helene Sicard
4
Guy Dubreuilh
Jean-Jacques Fournié
1
Séverine Fruchon 2
Author
Fatima L’faqihi-Olive
Author
Frédéric Pont 1
Author
Mourad Mekaouche 3
Author
Sophie Ingoure
Author
Helene Sicard 4
Author
Guy Dubreuilh
Author
Jean-Jacques Fournié 1
Mail :
Author IdHAL : jean-jacques-fournie
1
CRCT - Centre de Recherches en Cancérologie de Toulouse (Centre de Recherches en Cancérologie de Toulouse
2 Avenue Hubert Curien
31037 Toulouse Cedex 1
FRANCE - France)
- UT3 - Université Toulouse III - Paul Sabatier (118 route de Narbonne - 31062 Toulouse - France)
- Université Fédérale Toulouse Midi-Pyrénées (41 Allée Jules Guesde, 31000 Toulouse - France)
- INSERM - Institut National de la Santé et de la Recherche Médicale : U1037 (101, rue de Tolbiac, 75013 Paris - France)
- CNRS - Centre National de la Recherche Scientifique : ERL5294 (France)
2
CPTP - Centre de Physiopathologie Toulouse Purpan ex IFR 30 et IFR 150 (Hôpital de Purpan Place du Docteur Baylac 31024 TOULOUSE CEDEX 3 - France)
- INSERM - Institut National de la Santé et de la Recherche Médicale : U1043 (101, rue de Tolbiac, 75013 Paris - France)
- UT3 - Université Toulouse III - Paul Sabatier (118 route de Narbonne - 31062 Toulouse - France)
- Université Fédérale Toulouse Midi-Pyrénées (41 Allée Jules Guesde, 31000 Toulouse - France)
- CNRS - Centre National de la Recherche Scientifique : UMR5282 (France)
3
SP - Station de primatologie (CD 56 13790 ROUSSET - France)
- CNRS - Centre National de la Recherche Scientifique : UPS846 (France)
4
Recherche & Développement (Laboratoires Pharmaceutiques - 117 Avenue de Luminy 13276 Marseille - France)
- Innate Pharma (117, Avenue de Luminy - BP 30191 13276 Marseille Cedex 09 - France)
Abstract : Phosphoantigens (PAgs) activate Vγ9Vδ2 T lymphocytes, inducing their potent and rapid response in vitro and in vivo. However, humans and nonhuman primates that receive repeated injections of PAgs progressively lose their Vγ9Vδ2 T cell response to them. To elucidate the molecular mechanisms of this in vivo desensitization, we analyzed the transcriptome of circulating Vγ9Vδ2 T cells from macaques injected with PAg. We showed that three PAg injections induced the activation of the PPARα pathway in Vγ9Vδ2 T cells. Thus, we analyzed the in vitro response of Vγ9Vδ2 T cells stimulated with a PPARα agonist. We demonstrated that in vitro PPARα pathway activation led to the inhibition of the BrHPP-induced activation and proliferation of human Vγ9Vδ2 T cells. Since the PPARα pathway is involved in the antigen-selective desensitization of human Vγ9Vδ2 T cells, the use of PPARα inhibitors could enhance cancer immunotherapy based on Vγ9Vδ2 T cells.
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https://www.hal.inserm.fr/inserm-02472220
Contributor : Mary Poupot <>
Submitted on : Monday, February 10, 2020 - 9:52:32 AM
Last modification on : Tuesday, March 17, 2020 - 2:02:03 PM
Contributor : Mary Poupot <>
Submitted on : Monday, February 10, 2020 - 9:52:32 AM
Last modification on : Tuesday, March 17, 2020 - 2:02:03 PM
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Identifiers
- HAL Id : inserm-02472220, version 1
- DOI : 10.2478/s11658-014-0218-0
- PUBMED : 25424910
- PUBMEDCENTRAL : PMC6275808
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Citation
Mary Poupot, Frédéric Boissard, Delphine Bétous, Laure Bardouillet, Séverine Fruchon, et al.. The PPARα pathway in Vγ9Vδ2 T cell anergy. Cellular and Molecular Biology Letters, Springer Verlag (Germany), 2014, 19 (4), pp.649-58. ⟨10.2478/s11658-014-0218-0⟩. ⟨inserm-02472220⟩
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