Multiorgan failure is an adaptive, endocrine-mediated, metabolic response to overwhelming systemic inflammation, Lancet, vol.364, issue.9433, pp.545-553, 2004. ,
Severe sepsis and septic shock, N Engl J Med, vol.369, issue.21, p.2063, 2013. ,
Sepsis: current dogma and new perspectives, Immunity, vol.40, issue.4, pp.463-75, 2014. ,
Benchmarking the incidence and mortality of severe sepsis in the United States, Crit Care Med, vol.41, issue.5, pp.1167-74, 2013. ,
Assessment of Global Incidence and Mortality of Hospitaltreated Sepsis. Current Estimates and Limitations, Am J Respir Crit Care Med, vol.193, issue.3, pp.259-72, 2016. ,
Thrombocytopenia in the intensive care unit, Chest, vol.104, issue.4, pp.1243-1250, 1993. ,
Thrombocytopenic disorders in critically ill patients, Am J Respir Crit Care Med, vol.162, issue.2, pp.347-51, 2000. ,
Thrombocytopenia and prognosis in intensive care, Crit Care Med, vol.28, issue.6, pp.1871-1877, 2000. ,
Thrombocytopenia in patients in the medical intensive care unit: bleeding prevalence, transfusion requirements, and outcome, Crit Care Med, vol.30, issue.8, pp.1765-71, 2002. ,
Serial determinations of platelets, leucocytes and coagulation parameters in surgical septicemia, Scand J Clin Lab Invest Suppl, vol.178, pp.7-14, 1985. ,
Time course of platelet counts in critically ill patients, Crit Care Med, vol.30, issue.4, pp.753-759, 2002. ,
Thrombocytopenia in medical-surgical critically ill patients: prevalence, incidence, and risk factors, J Crit Care, vol.20, issue.4, pp.348-53, 2005. ,
Platelet count decline: an early prognostic marker in critically ill patients with prolonged ICU stays, Chest, vol.131, issue.6, pp.1735-1776, 2007. ,
URL : https://hal.archives-ouvertes.fr/inserm-00348865
The frequency and clinical significance of thrombocytopenia complicating critical illness: a systematic review, Chest, vol.139, issue.2, pp.271-279, 2011. ,
Thrombocytopenia in adult patients with sepsis: incidence, risk factors, and its association with clinical outcome, J Intensive Care, vol.1, issue.1, p.9, 2013. ,
Platelets and innate immunity, Cell Mol Life Sci, vol.67, issue.4, pp.499-511, 2010. ,
Platelets and the immune continuum, Nat Rev Immunol, vol.11, issue.4, pp.264-74, 2011. ,
Platelets: versatile effector cells in hemostasis, inflammation, and the immune continuum, Semin Immunopathol, vol.34, issue.1, pp.5-30, 2012. ,
Platelets in inflammation and immunity, J Thromb Haemost, vol.12, issue.11, pp.1764-75, 2014. ,
Emerging roles for platelets as immune and inflammatory cells, Blood, vol.123, issue.18, pp.2759-67, 2014. ,
Platelets are versatile cells: new discoveries in hemostasis, thrombosis, immune responses, tumor metastasis and beyond, Crit Rev Clin Lab Sci, vol.53, issue.6, pp.409-439, 2016. ,
New frontiers for platelet CD154, Exp Hematol Oncol, vol.4, p.6, 2015. ,
The role of platelets in inflammation, Thromb Haemost, vol.114, issue.3, pp.449-58, 2015. ,
The third international consensus definitions for sepsis and septic shock (sepsis-3), JAMA, vol.315, issue.8, pp.801-811, 2016. ,
The enigma of sepsis, J Clin Investig, vol.112, issue.4, pp.460-467, 2003. ,
Sepsis biomarkers: a review, Crit Care, vol.14, issue.1, p.15, 2010. ,
Current trends in inflammatory and immunomodulatory mediators in sepsis, J Leukoc Biol, vol.93, issue.3, pp.329-371, 2013. ,
Host response biomarkers in the diagnosis of sepsis: a general overview, Methods Mol Biol, vol.1237, pp.149-211, 2015. ,
Thrombocytopenia is associated with a dysregulated host response in critically ill sepsis patients, Blood, vol.127, issue.24, pp.3062-72, 2016. ,
Procalcitonin and cytokine levels: relationship to organ failure and mortality in pediatric septic shock, Crit Care Med, vol.28, issue.7, pp.2591-2595, 2000. ,
Inflammation, coagulopathy, and the pathogenesis of multiple organ dysfunction syndrome, Crit Care Med, vol.29, issue.7, pp.99-106, 2001. ,
Biomarkers of endothelial activation are associated with poor outcome in critical illness, PLoS ONE, vol.10, issue.10, p.141251, 2015. ,
Harmful molecular mechanisms in sepsis, Nat Rev Immunol, vol.8, issue.10, pp.776-87, 2008. ,
The pathogenesis of sepsis, Annu Rev Pathol, vol.6, pp.19-48, 2011. ,
Host innate immune responses to sepsis, Virulence, vol.5, issue.1, pp.36-44, 2014. ,
Microbial recognition and danger signals in sepsis and trauma, Biochim Biophys Acta, vol.1863, pp.2564-73, 2017. ,
A genomic storm in critically injured humans, J Exp Med, vol.208, issue.13, pp.2581-90, 2011. ,
Normal responses to injury prevent systemic inflammation and can be immunosuppressive, Am J Respir Crit Care Med, vol.163, issue.2, pp.316-337, 2001. ,
The pathophysiology and treatment of sepsis, N Engl J Med, vol.348, issue.2, pp.138-50, 2003. ,
The compensatory anti-inflammatory response syndrome (CARS) in critically ill patients, Clin Chest Med, vol.29, issue.4, pp.617-642, 2008. ,
Sepsis: multiple abnormalities, heterogeneous responses, and evolving understanding, Physiol Rev, vol.93, issue.3, pp.1247-88, 2013. ,
Sepsis-induced immunosuppression: from cellular dysfunctions to immunotherapy, Nat Rev Immunol, vol.13, issue.12, pp.862-74, 2013. ,
The immune system's role in sepsis progression, resolution, and long-term outcome, Immunol Rev, vol.274, issue.1, pp.330-53, 2016. ,
The incredible journey: from megakaryocyte development to platelet formation, J Cell Biol, vol.201, issue.6, pp.785-96, 2013. ,
Thrombopoietin from beginning to end, Br J Haematol, vol.165, issue.2, pp.259-68, 2014. ,
The regulation of platelet life span, Platelets, pp.51-66, 2013. ,
Regulating billions of blood platelets: glycans and beyond, Blood, vol.126, issue.16, pp.1877-84, 2015. ,
The platelet release reaction: granules' constituents, secretion and functions, Platelets, vol.12, issue.5, pp.261-73, 2001. ,
Characterization of the proteins released from activated platelets leads to localization of novel platelet proteins in human atherosclerotic lesions, Blood, vol.103, issue.6, pp.2096-104, 2004. ,
Platelets and wound healing, Front Biosci, vol.13, pp.3532-3580, 2008. ,
Platelet-derived microparticles, Platelets, pp.403-416, 2013. ,
Platelet microvesicles in health and disease, Platelets, vol.28, issue.3, pp.214-235, 2017. ,
Recently recognized platelet agonists, Curr Opin Hematol, vol.18, issue.5, pp.309-323, 2011. ,
Platelets and thrombin generation, Arterioscler Thromb Vasc Biol, vol.22, issue.9, pp.1381-1390, 2002. ,
Platelets, inflammation and tissue regeneration, Thromb Haemost, vol.105, issue.1, pp.13-33, 2011. ,
Bench-to-bedside review: platelets and active immune functions-new clues for immunopathology? Crit Care, vol.17, p.236, 2013. ,
The biology of the platelet with special reference to inflammation, wound healing and immunity, Front Biosci (Landmark Ed), vol.01, issue.23, pp.726-51, 2018. ,
Nouvelle cuisine: platelets served with inflammation, J Immunol, vol.194, issue.12, pp.5579-87, 2015. ,
Platelet secretion in inflammatory and infectious diseases, Platelets, vol.28, issue.2, pp.155-64, 2017. ,
Interactions of platelets with subendothelium and endothelium. Microcirculation, vol.12, pp.235-281, 2005. ,
Platelets and endothelial cells, Semin Thromb Hemost, vol.33, issue.2, pp.128-163, 2007. ,
Glycobiology of platelet-endothelial cell interactions, Glycobiology, vol.24, issue.12, pp.1252-1261, 2014. ,
Modulation of endothelial glycocalyx structure under inflammatory conditions, Mediat Inflamm, p.694312, 2014. ,
Adhesion molecules: master controllers of the circulatory system, Compr Physiol, vol.6, issue.2, pp.945-73, 2016. ,
Neutrophil and platelet complexes and their relevance to neutrophil recruitment and activation. Int Immunopharmacol, vol.17, pp.1176-84, 2013. ,
Platelets: inflammatory firebugs of vascular walls, Arterioscler Thromb Vasc Biol, vol.28, issue.3, pp.5-10, 2008. ,
Platelet-vessel wall interaction in health and disease, Neth J Med, vol.68, issue.6, pp.242-51, 2010. ,
Platelets: a critical link between inflammation and microvascular dysfunction, J Physiol, vol.590, pp.1023-1057, 2012. ,
Platelets as cellular effectors of inflammation in vascular diseases, Circ Res, vol.112, issue.11, pp.1506-1525, 2013. ,
The role of platelets in the recruitment of leukocytes during vascular disease, Platelets, vol.26, issue.6, pp.507-527, 2015. ,
Platelets in pulmonary immune responses and inflammatory lung diseases, Physiol Rev, vol.96, issue.4, pp.1211-59, 2016. ,
Neutrophils scan for activated platelets to initiate inflammation, Science, vol.346, issue.6214, pp.1234-1242, 2014. ,
Platelets guide leukocytes to their sites of extravasation, PLoS Biol, vol.14, issue.5, p.1002459, 2016. ,
Circulating platelet-neutrophil complexes represent a subpopulation of activated neutrophils primed for adhesion, phagocytosis and intracellular killing, Br J Haematol, vol.106, issue.2, pp.391-400, 1999. ,
TREM-1 ligand expression on platelets enhances neutrophil activation, Blood, vol.110, issue.3, pp.1029-1064, 2007. ,
Platelets in inflammation: regulation of leukocyte activities and vascular repair, Front Immunol, vol.5, p.678, 2014. ,
Platelet interaction with innate immune cells, Transfus Med Hemother, vol.43, issue.2, pp.78-88, 2016. ,
Platelet activation and interaction with leucocytes in patients with sepsis or multiple organ failure, Eur J Clin Investig, vol.25, issue.11, pp.843-51, 1995. ,
Platelet and leukocyte activation correlate with the severity of septic organ dysfunction, Shock, vol.17, issue.4, pp.263-271, 2002. ,
Effects of endotoxemia on thrombopoiesis in men, Thromb Haemost, vol.81, issue.4, pp.613-620, 1999. ,
Circulating monocyte-platelet aggregates are a more sensitive marker of in vivo platelet activation than platelet surface P-selectin: studies in baboons, human coronary intervention, and human acute myocardial infarction, Circulation, vol.104, issue.13, pp.1533-1540, 2001. ,
Platelets, complement and tissue inflammation, Autoimmunity, vol.46, issue.1, pp.1-5, 2013. ,
Small but mighty: platelets as central effectors of host defense, Thromb Haemost, vol.117, issue.4, pp.651-61, 2017. ,
Thrombosis as an intravascular effector of innate immunity, Nat Rev Immunol, vol.13, issue.1, pp.34-45, 2013. ,
Platelet polyphosphates are proinflammatory and procoagulant mediators in vivo, Cell, vol.139, issue.6, pp.1143-56, 2009. ,
The interactions between inflammation and coagulation, Br J Haematol, vol.131, issue.4, pp.417-447, 2005. ,
Coagulation inhibitors in inflammation, Biochem Soc Trans, vol.33, issue.2, pp.401-406, 2005. ,
Sepsis-associated disseminated intravascular coagulation and thromboembolic disease, Mediterr J Hematol Infect Dis, vol.2, issue.3, p.2010024, 2010. ,
Coagulation and sepsis, Thromb Res, vol.149, pp.38-44, 2017. ,
The coagulopathy of acute sepsis, Curr Opin Anaesthesiol, vol.28, issue.2, pp.227-263, 2015. ,
Platelets and coagulation in infection, Clin Transl Immunol, vol.5, issue.7, p.89, 2016. ,
Platelets, neutrophils, and neutrophil extracellular traps (NETs) in sepsis, J Thromb Haemost, vol.6, issue.3, pp.415-435, 2008. ,
Platelet-leukocyte crosstalk: linking proinflammatory responses to procoagulant state, Thromb Res, vol.131, issue.3, pp.191-198, 2013. ,
Platelets: new bricks in the building of neutrophil extracellular traps, Front Immunol, vol.7, p.271, 2016. ,
The role of leukocytes in thrombosis, Blood, vol.128, issue.6, pp.753-62, 2016. ,
Platelets and neutrophil extracellular traps collaborate to promote intravascular coagulation during sepsis in mice, Blood, vol.129, issue.10, pp.1357-67, 2017. ,
Cellular origin and procoagulant properties of microparticles in meningococcal sepsis, Blood, vol.95, issue.3, pp.930-935, 2000. ,
Microparticles in vascular diseases, Thromb Res, vol.122, issue.1, pp.55-64, 2008. ,
Clinical relevance of microparticles from platelets and megakaryocytes, Curr Opin Hematol, vol.17, issue.6, pp.578-84, 2010. ,
Role of microparticles in sepsis, Br J Anaesth, vol.109, issue.4, pp.503-516, 2012. ,
Microparticles and acute renal dysfunction in septic patients, J Crit Care, vol.28, issue.2, pp.141-148, 2013. ,
Microparticles: markers and mediators of sepsis-induced microvascular dysfunction, immunosuppression, and AKI, Kidney Int, vol.87, issue.6, pp.1100-1108, 2015. ,
Blood platelets and inflammation: their relationship with liver and digestive diseases, Clin Res Hepatol Gastroenterol, vol.35, issue.5, pp.353-360, 2011. ,
Platelets in tissue repair: control of apoptosis and interactions with regenerative cells, Blood, vol.122, issue.15, pp.2550-2554, 2013. ,
Platelet secretion: from haemostasis to wound healing and beyond, Blood Rev, vol.29, issue.3, pp.153-62, 2015. ,
Platelets, petechiae, and preservation of the vascular wall, N Engl J Med, vol.359, issue.12, pp.1261-70, 2008. ,
How platelets safeguard vascular integrity, J Thromb Haemost, vol.9, issue.1, pp.56-65, 2011. ,
Platelets in lung biology, Annu Rev Physiol, vol.75, pp.569-91, 2013. ,
Ultrastructural changes of endothelium associated with thrombocytopenia, Blood, vol.46, issue.4, pp.567-78, 1975. ,
Platelets at work in primary hemostasis, Blood Rev, vol.25, issue.4, pp.155-67, 2011. ,
New fundamentals in hemostasis, Physiol Rev, vol.93, issue.1, pp.327-58, 2013. ,
Inflammation induces hemorrhage in thrombocytopenia, Blood, vol.111, issue.10, pp.4958-64, 2008. ,
Platelet-derived factors involved in tissue repair-from signal to function, Transfus Med Rev, vol.24, issue.3, pp.218-252, 2010. ,
Platelet-derived SDF-1 primes the pulmonary capillary vascular niche to drive lung alveolar regeneration, Nat Cell Biol, vol.17, issue.2, pp.123-159, 2015. ,
Microparticles in endothelial cell and vascular homeostasis: are they really noxious?, Haematologica, vol.94, issue.3, pp.313-320, 2009. ,
Platelets: at the nexus of antimicrobial defence, Nat Rev Microbiol, vol.12, issue.6, pp.426-463, 2014. ,
Platelets and the innate immune system: mechanisms of bacterial-induced platelet activation, J Thromb Haemost, vol.9, issue.6, pp.1097-107, 2011. ,
The expanding field of platelet-bacterial interconnections, Platelets, vol.26, issue.4, pp.293-301, 2015. ,
Toll-like receptor signalling is not involved in platelet response to streptococcus pneumoniae in vitro or in vivo, PLoS ONE, vol.11, issue.6, p.156977, 2016. ,
Platelets and infections-complex interactions with bacteria, Front Immunol, vol.6, p.82, 2015. ,
The interaction of bacterial pathogens with platelets, Nat Rev Microbiol, vol.4, issue.6, pp.445-57, 2006. ,
Alarmins: awaiting a clinical response, J Clin Investig, vol.122, issue.8, pp.2711-2720, 2012. ,
Extracellular histones promote thrombin generation through platelet-dependent mechanisms: involvement of platelet TLR2 and TLR4, Blood, vol.118, issue.7, pp.1952-61, 2011. ,
The role of platelets in sepsis, Thromb Haemost, vol.112, issue.4, pp.666-77, 2014. ,
The emerging role of platelets in adaptive immunity, Cell Immunol, vol.238, issue.1, pp.1-9, 2005. ,
Platelets in infectious disease, Hematol Am Soc Hematol Educ Program, vol.2016, issue.1, pp.256-61, 2016. ,
Involvement of bactericidal factors from thrombin-stimulated platelets in clearance of adherent viridans streptococci in experimental infective endocarditis, Infect Immun, vol.63, issue.2, pp.663-71, 1995. ,
Platelets kill intraerythrocytic malarial parasites and mediate survival to infection, Science, vol.323, issue.5915, pp.797-800, 2009. ,
Thrombocytopenia impairs host defense in gram-negative pneumonia-derived sepsis in mice, Blood, vol.124, issue.25, pp.3781-90, 2014. ,
Platelets promote bacterial dissemination in a mouse model of streptococcal sepsis, Microbes Infect, vol.15, pp.669-76, 2013. ,
The disconnect between animal models of sepsis and human sepsis, J Leukoc Biol, vol.81, issue.1, pp.137-180, 2007. ,
Animal models of sepsis and sepsis-induced kidney injury, J Clin Investig, vol.119, issue.10, pp.2868-78, 2009. ,
New approaches to the study of sepsis, EMBO Mol Med, vol.4, issue.12, pp.1234-1277, 2012. ,
Animal models of sepsis, Virulence, vol.5, issue.1, pp.143-53, 2014. ,
Microvascular endothelial dysfunction: a renewed appreciation of sepsis pathophysiology, Crit Care, vol.5, issue.2, pp.1-5, 2001. ,
The role of the endothelium in severe sepsis and multiple organ dysfunction syndrome, Blood, vol.101, issue.10, pp.3765-77, 2003. ,
Bench-to-bedside review: microvascular dysfunction in sepsis-hemodynamics, oxygen transport, and nitric oxide, Crit Care, vol.7, issue.5, pp.359-73, 2003. ,
Molecular basis of endothelial dysfunction in sepsis, Cardiovasc Res, vol.60, issue.1, pp.49-57, 2003. ,
Platelet-endothelial interactions: sepsis, HIT, and antiphospholipid syndrome, Hematol Am Soc Hematol Educ Program, pp.497-519, 2003. ,
Vascular biology in sepsis: pathophysiological and therapeutic significance of vascular dysfunction, J Smooth Muscle Res, vol.43, issue.4, pp.117-154, 2007. ,
Inflammation, endothelium, and coagulation in sepsis, J Leukoc Biol, vol.83, issue.3, pp.536-581, 2008. ,
Microvascular thrombosis and multiple organ dysfunction syndrome, Crit Care Med, vol.38, issue.2, pp.35-42, 2010. ,
Broken barriers: a new take on sepsis pathogenesis, Sci Transl Med, vol.3, issue.88, pp.88-113, 2011. ,
Critical role for oxidative stress, platelets, and coagulation in capillary blood flow impairment in sepsis, Microcirculation, vol.18, issue.2, pp.152-62, 2011. ,
Endothelial dysfunction in sepsis, Curr Vasc Pharmacol, vol.11, issue.2, pp.150-60, 2013. ,
URL : https://hal.archives-ouvertes.fr/hal-00836911
Pathophysiology of microcirculatory dysfunction and the pathogenesis of septic shock, Virulence, vol.5, issue.1, pp.73-82, 2014. ,
Endothelial barrier dysfunction in septic shock, J Int Med, vol.277, issue.3, pp.277-93, 2015. ,
The endothelium in sepsis, Shock, vol.45, issue.3, pp.259-70, 2016. ,
Clinical utility of biomarkers of endothelial activation in sepsis-a systematic review, Crit Care, vol.16, issue.1, p.7, 2012. ,
The endothelium: physiological functions and role in microcirculatory failure during severe sepsis, Intensive Care Med, vol.36, issue.8, pp.1286-98, 2010. ,
Circulatory shock, N Engl J Med, vol.369, issue.18, pp.1726-1760, 2013. ,
Platelet function in septic multiple organ dysfunction syndrome, Intensive Care Med, vol.23, issue.4, pp.379-85, 1997. ,
The dynamics of platelet activation during the progression of streptococcal sepsis, PLoS ONE, vol.11, issue.9, p.163531, 2016. ,
Platelets in critical illness, Semin Thromb Hemost, vol.42, issue.3, pp.252-259, 2016. ,
The role of platelets in the adult respiratory distress syndrome. Culprits or bystanders?, Am Rev Respir Dis, vol.135, issue.2, pp.482-92, 1987. ,
Amicus or adversary: platelets in lung biology, acute injury, and inflammation, Am J Respir Cell Mol Biol, vol.40, issue.2, pp.123-157, 2009. ,
Linking genetics to ARDS pathogenesis: the role of the platelet, Chest, vol.147, issue.3, pp.585-591, 2015. ,
Platelets in the pathogenesis of acute respiratory distress syndrome, Am J Physiol Lung Cell Mol Physiol, vol.28, p.266, 2015. ,
The acute respiratory distress syndrome, N Engl J Med, vol.342, issue.18, pp.1334-1383, 2000. ,
Regulation and repair of the alveolar-capillary barrier in acute lung injury, Annu Rev Physiol, vol.75, pp.593-615, 2013. ,
Platelet-endothelial cell interaction in pulmonary micro-circulation: the role of PARS, Thromb Haemost, vol.91, issue.4, pp.761-70, 2004. ,
Complete reversal of acid-induced acute lung injury by blocking of platelet-neutrophil aggregation, J Clin Investig, vol.116, issue.12, pp.3211-3220, 2006. ,
Platelet depletion and aspirin treatment protect mice in a twoevent model of transfusion-related acute lung injury, J Clin Investig, vol.119, issue.11, pp.3450-61, 2009. ,
Aspirin-triggered 15-epi-lipoxin A4 regulates neutrophilplatelet aggregation and attenuates acute lung injury in mice, Blood, vol.124, issue.17, pp.2625-2659, 2014. ,
Beyond thrombosis: the versatile platelet in critical illness, Chest, vol.139, issue.3, pp.658-68, 2011. ,
Platelets induce apoptosis during sepsis in a contact-dependent manner that is inhibited by GPIIb/IIIa blockade, PLoS ONE, vol.7, issue.7, p.41549, 2012. ,
Neutrophils in development of multiple organ failure in sepsis, Lancet, vol.368, issue.9530, pp.157-69, 2006. ,
The role of platelets in acute lung injury (ALI), vol.01, pp.150-158, 2009. ,
Coagulation, fibrinolysis, and fibrin deposition in acute lung injury, Crit Care Med, vol.31, issue.4, pp.213-233, 2003. ,
Platelets induce neutrophil extracellular traps in transfusion-related acute lung injury, J Clin Investig, vol.122, issue.7, pp.2661-71, 2012. ,
Microparticles and acute lung injury, Am J Physiol Lung Cell Mol Physiol, vol.303, issue.5, pp.364-81, 2012. ,
Platelets support pulmonary recruitment of neutrophils in abdominal sepsis, Crit Care Med, vol.37, issue.4, pp.1389-96, 2009. ,
Platelets can enhance vascular permeability, Blood, vol.120, issue.6, pp.1334-1377, 2012. ,
Genetic polymorphisms associated with acute lung injury, Pharmacogenomics, vol.10, issue.9, pp.1527-1566, 2009. ,
Platelet count mediates the contribution of a genetic variant in LRRC16A to ARDS risk, Chest, vol.147, issue.3, pp.607-624, 2015. ,
Microvascular blood flow is altered in patients with sepsis, Am J Respir Crit Care Med, vol.166, issue.1, pp.98-104, 2002. ,
Acute renal failure and sepsis, N Engl J Med, vol.351, issue.2, pp.159-69, 2004. ,
Renal blood flow in experimental septic acute renal failure, Kidney Int, vol.69, issue.11, pp.1996-2002, 2006. ,
Recent knowledge on the pathophysiology of septic acute kidney injury: a narrative review, J Crit Care, vol.31, issue.1, pp.82-91, 2016. ,
Renal perfusion in sepsis: from macro-to microcirculation, Kidney Int, vol.91, issue.1, pp.45-60, 2017. ,
Pathophysiology of septic acute kidney injury: what do we really know?, Crit Care Med, vol.36, issue.4, pp.198-203, 2008. ,
Histopathology of septic shock induced acute kidney injury: apoptosis and leukocytic infiltration, Intensive Care Med, vol.36, issue.3, pp.471-479, 2010. ,
Septic acute kidney injury: the culprit is inflammatory apoptosis rather than ischemic necrosis, Blood Purif, vol.32, issue.4, pp.262-267, 2011. ,
Mechanisms of cardiac and renal dysfunction in patients dying of sepsis, Am J Respir Crit Care Med, vol.187, issue.5, pp.509-526, 2013. ,
Renal blood flow in sepsis, Crit Care, vol.9, issue.4, pp.363-74, 2005. ,
Renal blood flow during acute renal failure in man, Blood Purif, vol.28, issue.3, pp.216-241, 2009. ,
New developments in septic acute kidney injury, Physiol Res, vol.59, issue.6, pp.859-69, 2010. ,
Acute kidney injury in non-severe pneumonia is associated with an increased immune response and lower survival, Kidney Int, vol.77, issue.6, pp.527-562, 2010. ,
Impaired renal blood flow and the 'spicy food' hypothesis of acute kidney injury, Crit Care Med, vol.39, issue.4, pp.901-904, 2011. ,
Sepsis and acute kidney injury, J Am Soc Nephrol, vol.22, issue.6, pp.999-1006, 2011. ,
Pathophysiology of acute kidney injury, Compr Physiol, vol.2, issue.2, pp.1303-53, 2012. ,
A unified theory of sepsis-induced acute kidney injury: inflammation, microcirculatory dysfunction, bioenergetics, and the tubular cell adaptation to injury, Shock, vol.41, issue.1, pp.3-11, 2014. ,
Recent advances in pathophysiology and biomarkers of sepsis-induced acute kidney injury, J Infect, vol.72, pp.131-173, 2015. ,
Sepsis-induced acute kidney injury, Curr Opin Crit Care, vol.22, issue.6, pp.546-53, 2016. ,
Acute kidney injury in sepsis, Intensive Care Med, vol.43, issue.6, pp.816-844, 2017. ,
Cellular pathophysiology of ischemic acute kidney injury, J Clin Investig, vol.121, issue.11, pp.4210-4231, 2011. ,
Sepsis-induced acute kidney injury revisited: pathophysiology, prevention and future therapies, Curr Opin Crit Care, vol.20, issue.6, pp.588-95, 2014. ,
New insights into the mechanisms of acute kidney injury in the intensive care unit, J Clin Anesth, vol.27, issue.2, pp.175-80, 2015. ,
Platelets are relevant mediators of renal injury induced by primary endothelial lesions, Am J Physiol Renal Physiol, vol.308, issue.11, pp.1238-1284, 2015. ,
Nanomechanics of the endothelial glycocalyx in experimental sepsis, PLoS ONE, vol.8, issue.11, p.80905, 2013. ,
Degradation of the endothelial glycocalyx in clinical settings: searching for the sheddases, Br J Clin Pharmacol, vol.80, issue.3, pp.389-402, 2015. ,
Glycocalyx and sepsis-induced alterations in vascular permeability, Crit Care, vol.28, issue.19, p.26, 2015. ,
The endothelial glycocalyx: new diagnostic and therapeutic approaches in sepsis, Biomed Res Int, p.3758278, 2016. ,
Acute kidney injury, Annu Rev Med, vol.14, issue.67, pp.293-307, 2016. ,
Impact of acute kidney injury on distant organ function: recent findings and potential therapeutic targets, Kidney Int, vol.89, issue.3, pp.555-64, 2016. ,
Platelets orchestrate remote tissue damage after mesenteric ischemia-reperfusion, Am J Physiol Gastrointest Liver Physiol, vol.302, issue.8, pp.888-97, 2012. ,
Differential effects of kidney-lung cross-talk during acute kidney injury and bacterial pneumonia, Kidney Int, vol.80, issue.6, pp.633-677, 2011. ,
Platelet-associated CD40/CD154 mediates remote tissue damage after mesenteric ischemia/reperfusion injury, PLoS ONE, vol.7, issue.2, p.32260, 2012. ,
The role of platelet factor 4 in local and remote tissue damage in a mouse model of mesenteric ischemia/reperfusion injury, PLoS ONE, vol.7, issue.7, p.39934, 2012. ,
CD40 ligand on activated platelets triggers an inflammatory reaction of endothelial cells, Nature, vol.391, issue.6667, pp.591-595, 1998. ,
Cd40 ligand-deficient mice are protected against cerulein-induced acute pancreatitis and pancreatitis-associated lung injury, Gastroenterology, vol.121, issue.1, pp.184-94, 2001. ,
CD40 plays a crucial role in lipopolysaccharide-induced acute lung injury, Am J Respir Cell Mol Biol, vol.30, issue.6, pp.808-823, 2004. ,
Platelet-derived CD40L (CD154) mediates neutrophil upregulation of Mac-1 and recruitment in septic lung injury, Ann Surg, vol.250, issue.5, pp.783-90, 2009. ,
Thrombocytopenia in a surgical ICU, Chest, vol.115, issue.5, pp.1363-70, 1999. ,
Coagulation system and platelets are fully activated in uncomplicated sepsis, Crit Care Med, vol.28, issue.2, pp.451-458, 2000. ,
Blunted rise in platelet count in critically ill patients is associated with worse outcome, Crit Care Med, vol.28, issue.12, pp.3843-3849, 2000. ,
Thrombocytopenia in septic shock patients-a prospective observational study of incidence, risk factors and correlation with clinical outcome, Anaesth Intensive Care, vol.35, issue.6, pp.874-80, 2007. ,
Epidemiology and outcome of thrombocytopenic patients in the intensive care unit: results of a prospective multicenter study, Intensive Care Med, vol.39, issue.8, pp.1460-1468, 2013. ,
URL : https://hal.archives-ouvertes.fr/hal-00834510
Thrombocytopenia in the critically ill: prevalence, incidence, risk factors, and clinical outcomes, Can J Anaesth, vol.60, issue.7, pp.641-51, 2013. ,
Platelet and mean platelet volume kinetics in adult patients with sepsis, Platelets, vol.26, issue.4, pp.331-336, 2015. ,
Is thrombocytopenia an early prognostic marker in septic shock?, Crit Care Med, vol.44, issue.4, pp.764-72, 2016. ,
URL : https://hal.archives-ouvertes.fr/hal-01410073
Thrombocytopenia in the intensive care unit patient, Hematol Am Soc Hematol Educ Program, vol.2010, pp.135-178, 2010. ,
Incidence, risk factors, and outcome of severe sepsis and septic shock in adults. A multicenter prospective study in intensive care units. French ICU Group for Severe Sepsis, JAMA, vol.274, issue.12, pp.968-74, 1995. ,
A prospective, observational registry of patients with severe sepsis: the Canadian Sepsis Treatment and Response Registry, Crit Care Med, vol.37, issue.1, pp.81-89, 2009. ,
Early-onset and persisting thrombocytopenia in post-cardiac surgery patients is rarely due to heparin-induced thrombocytopenia, even when antibody tests are positive, J Thromb Haemost, vol.8, issue.1, pp.30-36, 2010. ,
Thrombocytopenia and outcome in critically ill patients with bloodstream infection, Heart Lung, vol.39, issue.1, pp.21-27, 2010. ,
The incidence, causes, and prognostic significance of new-onset thrombocytopenia in intensive care units: a prospective cohort study in a Korean hospital, J Korean Med Sci, vol.27, issue.11, pp.1418-1441, 2012. ,
Platelet transfusions for critically ill patients with thrombocytopenia, Blood, vol.123, issue.8, pp.1146-51, 2014. ,
Thrombocytopenia in the critically ill: considering pathophysiology rather than looking for a magic threshold, Intensive Care Med, vol.39, issue.9, pp.1656-1665, 2013. ,
How I evaluate and treat thrombocytopenia in the intensive care unit patient, Blood, vol.128, issue.26, pp.3032-3074, 2016. ,
Platelet transfusion practices in the icu: data from a large transfusion registry, Chest, vol.150, issue.3, pp.516-539, 2016. ,
Mechanisms and etiologies of thrombocytopenia in the intensive care unit: impact of extensive investigations, Ann Intensive Care, vol.4, p.24, 2014. ,
URL : https://hal.archives-ouvertes.fr/inserm-01091425
Sepsis-associated thrombocytopenia, Thromb Res, vol.141, pp.11-17, 2016. ,
Understanding platelet dysfunction in sepsis, Intensive Care Med, vol.42, issue.4, pp.583-589, 2016. ,
Immature platelet fraction in predicting sepsis in critically ill patients, Intensive Care Med, vol.39, issue.4, pp.636-679, 2013. ,
Platelets at a crossroad of pathogenic pathways in sepsis, J Thromb Haemost, vol.2, issue.12, pp.2094-2099, 2004. ,
Platelet function in sepsis, J Thromb Haemost, vol.2, issue.12, pp.2096-102, 2004. ,
Hematologic changes in sepsis and their therapeutic implications, Semin Respir Crit Care Med, vol.25, issue.6, pp.645-59, 2004. ,
A rational approach to the diagnosis and management of thrombocytopenia in the hospitalized patient, Semin Hematol, vol.48, issue.4, pp.251-259, 2011. ,
Thrombocytopenia in the intensive care unit-diagnostic approach and management, Semin Hematol, vol.50, issue.3, pp.239-50, 2013. ,
Thrombocytopenia: an update, Int J Lab Hematol, vol.36, issue.3, pp.269-78, 2014. ,
How do we approach thrombocytopenia in critically ill patients?, Br J Haematol, vol.177, issue.1, pp.27-38, 2017. ,
Cytokine therapeutics for the treatment of sepsis: why has nothing worked?, Curr Pharm Des, vol.9, issue.1, pp.75-82, 2003. ,
Platelet P2Y12 inhibitors reduce systemic inflammation and its prothrombotic effects in an experimental human model, Arterioscler Thromb Vasc Biol, vol.35, issue.12, pp.2562-70, 2015. ,
Antiplatelet drugs and outcome in mixed admissions to an intensive care unit, Crit Care Med, vol.38, issue.1, pp.32-39, 2010. ,
Prehospitalization antiplatelet therapy is associated with a reduced incidence of acute lung injury: a population-based cohort study, Chest, vol.139, issue.2, pp.289-95, 2011. ,
Do aspirin and other antiplatelet drugs reduce the mortality in critically ill patients? Thrombosis, p.720254, 2012. ,
Acetyl salicylic acid usage and mortality in critically ill patients with the systemic inflammatory response syndrome and sepsis, Crit Care Med, vol.40, issue.6, pp.1761-1768, 2012. ,
Outcomes of severe sepsis and septic shock patients on chronic antiplatelet treatment: a historical cohort study, Crit Care Res Pract, p.782573, 2013. ,
Benefit of low-dose aspirin and non-steroidal anti-inflammatory drugs in septic patients, Crit Care, vol.17, issue.1, p.402, 2013. ,
Effects of low-dose acetylsalicylic acid and atherosclerotic vascular diseases on the outcome in patients with severe sepsis or septic shock, Platelets, vol.24, issue.6, pp.480-485, 2013. ,
Use of antiplatelet agents in sepsis: a glimpse into the future, Thromb Res, vol.133, issue.2, pp.131-139, 2014. ,
Prehospital aspirin use is associated with reduced risk of acute respiratory distress syndrome in critically ill patients: a propensity-adjusted analysis, Crit Care Med, vol.43, issue.4, pp.801-808, 2015. ,
Aspirin as a potential treatment in sepsis or acute respiratory distress syndrome, Crit Care, vol.19, p.374, 2015. ,
Association of prior antiplatelet agents with mortality in sepsis patients: a nationwide population-based cohort study, Intensive Care Med, vol.41, issue.5, pp.806-819, 2015. ,
Association of prehospitalization aspirin therapy and acute lung injury: results of a multicenter international observational study of at-risk patients, Crit Care Med, vol.39, issue.11, pp.2393-400, 2011. ,
Profile and prevalence of aspirin resistance in patients with cardiovascular disease, Am J Cardiol, vol.88, issue.3, pp.230-235, 2001. ,
Resistance to clopidogrel: a review of the evidence, J Am Coll Cardiol, vol.45, issue.8, pp.1157-64, 2005. ,
Aspirin resistance: definitions, mechanisms, prevalence, and clinical significance, Curr Pharm Des, vol.12, issue.2, pp.251-259, 2006. ,
Chronic antiplatelet therapy is not associated with alterations in the presentation, outcome, or host response biomarkers during sepsis: a propensity-matched analysis, Intensive Care Med, vol.42, issue.3, pp.352-60, 2016. ,
Effect of antiplatelet therapy on inflammatory markers in atherothrombotic patients, Thromb Haemost, vol.103, issue.1, pp.71-82, 2010. ,
Sepsis severity is the major determinant of circulating thrombopoietin levels in septic patients, Crit Care Med, vol.32, issue.4, pp.1004-1014, 2004. ,
Thrombopoietin as biomarker and mediator of cardiovascular damage in critical diseases, Mediat Inflamm, p.390892, 2012. ,
Blockade of thrombopoietin reduces organ damage in experimental endotoxemia and polymicrobial sepsis, PLoS ONE, vol.11, issue.3, p.151088, 2016. ,
Recombinant human thrombopoietin improves platelet counts and reduces platelet transfusion possibility among patients with severe sepsis and thrombocytopenia: a prospective study, J Crit Care, vol.29, issue.3, pp.362-368, 2014. ,
A normal platelet count at admission in acute meningococcal disease does not exclude a fulminant course, Intensive Care Med, vol.24, issue.2, pp.157-61, 1998. ,
Platelet counts and outcome in the pediatric intensive care unit, Indian J Crit Care Med, vol.12, issue.3, pp.102-110, 2008. ,
Effect of antiplatelet therapy on acute respiratory distress syndrome and mortality in critically ill patients: a meta-analysis, PLoS ONE, vol.11, issue.5, p.154754, 2016. ,
Effect of aspirin on development of ARDS in at-risk patients presenting to the emergency department: the LIPS-A randomized clinical trial, JAMA, vol.315, issue.22, pp.2406-2420, 2016. ,
Lowdose acetylsalicylic acid treatment and impact on short-term mortality in Staphylococcus aureus bloodstream infection: a propensity scorematched cohort study, Crit Care Med, vol.44, issue.4, pp.773-81, 2016. ,
Aspirin therapy in patients with acute respiratory distress syndrome (ARDS) is associated with reduced intensive care unit mortality: a prospective analysis, Crit Care, vol.19, p.109, 2015. ,
Prehospital statin and aspirin use and the prevalence of severe sepsis and acute lung injury/acute respiratory distress syndrome, Crit Care Med, vol.39, issue.6, pp.1343-50, 2011. ,
Lower mortality following pulmonary adverse events and sepsis with ticagrelor compared to clopidogrel in the PLATO study, Platelets, vol.25, issue.7, pp.517-542, 2014. ,
Anti-platelet drugs and outcome in severe infection: clinical impact and underlying mechanisms, Platelets, vol.20, issue.1, pp.50-57, 2009. ,
Clopidogrel treatment and the incidence and severity of community acquired pneumonia in a cohort study and meta-analysis of antiplatelet therapy in pneumonia and critical illness, J Thromb Thrombolysis, vol.35, issue.2, pp.147-54, 2013. ,