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Asthma is associated with frailty among community-dwelling adults -the GAZEL cohort

Abstract : Introduction: Early management of chronic respiratory diseases (CRDs) and frailty have been identified as key targets towards healthy ageing, but the association between CRDs and frailty has been poorly investigated. We studied the association between asthma and frailty in adults of the GAZEL cohort using different definitions of asthma over the 26 years of follow-up. Methods: Current asthma definitions are based on yearly self-reports of symptoms or medication (in 2015, constant reports or at least one report between 1990 and 2015), or on a detailed respiratory symptoms questionnaire in 2002. Frailty definition is based on weakness, fatigue, unintentional weight loss, low physical activity, and mobility in 2015. Frail participants had 3 criteria or more, pre-frail 1 or 2, and robust 0. Multinomial regression models, adjusted for age, sex, body mass index, smoking, education, marital status and comorbidities were performed. Results: In 2015, 12,345 adults (73% men, 61 to 77 years old) were included: 3% of them reported current asthma, 1.6% had constant reports during the follow-up and 9% reported current asthma at least once. In 2015, 6% were frail, 34% pre-frail and 13% of current asthmatics and 6% of non-asthmatics were frail (adjusted(a)OR: 2.19[1.44-3.34]). Significant associations were also found with the 2002 definition (aOR: 2.24[1.73-2.90]), constant reports (aOR: 3.67[1.70-7.93]) or at least once (aOR: 1.50[1.15-1.98]). Current asthma was also associated with pre-frailty with the 2002 definition (aOR: 1.46[1.26-1.68]). Discussion: Participants with asthma had increased risk of frailty. A better understanding of their relationship could help to define and evaluate strategies for a better aging of asthmatics.
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Benjamin Landré, Rachel Nadif, Marcel Goldberg, Julie Gourmelen, Marie Zins, et al.. Asthma is associated with frailty among community-dwelling adults -the GAZEL cohort. BMJ open respiratory research, BMJ Journals, In press, 7 (1), pp.e000526. ⟨10.1136/bmjresp-2019-000526⟩. ⟨inserm-02468172⟩



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