C. M. Hulette, K. A. Welsh-bohmer, M. G. Murray, and A. M. Saunders, , p.386

D. C. Mash and L. M. Mcintyre, Neuropathological and neu-Contribution of vascular injury and abeta to mild cognitive 681 dysfunction, JAMA Neurol, vol.70, 1998.

E. J. Van-dijk, N. D. Prins, S. E. Vermeer, A. Hofman, and . Van-duijn, , p.683

. Cm, P. J. Koudstaal, and M. M. Breteler, Plasma amyloid beta, p.684, 2004.

E. Apolipoprotein and . Lesions, , p.685

, Ann Neurol, vol.55, pp.570-575

Y. Noh, S. W. Seo, S. Jeon, J. M. Lee, J. H. Kim et al., , p.687

H. , Y. Cw, H. J. Kim, B. S. Ye, S. T. Kim et al., , p.688

J. S. Kim, M. Ewers, M. W. Weiner, J. H. Lee, D. J. Werring et al.,

V. Stenset, D. Hofoss, L. Johnsen, A. E. Berstad, and A. Negaard, , p.693

A. Skinningsrud, L. Gjerstad, and T. Fladby, White mat-694 ter lesion load increases the risk of low CSF Abeta42 in 695 apolipoprotein E-varepsilon4 carriers attending a memory 696 clinic, J Neuroimaging, vol.21, pp.78-82, 2011.

T. Grimmer, M. Faust, F. Auer, P. Alexopoulos, H. Forstl et al., Kurz A 699 (2012) White matter hyperintensities predict amyloid increase 700 in Alzheimer's disease, Neurobiol Aging, vol.33, pp.2766-2773

R. Y. Lo and W. J. Jagust, Vascular burden and Alzheimer 702 disease pathologic progression, Neurology, vol.79, pp.1349-1355, 2012.

M. Mortamais, C. Reynes, A. M. Brickman, and F. A. Provenzano, , p.704

J. Muraskin, F. Portet, C. Berr, J. Touchon, A. Bonafe et al., , p.705

J. J. Maller, C. Meslin, R. Sabatier, K. Ritchie, and S. Artero, , p.706, 2013.

, Spatial distribution of cerebral white matter lesions predicts 707 progression to mild cognitive impairment and dementia

A. M. Brickman, M. E. Zimmerman, R. H. Paul, S. M. Grieve, D. F. Tate-710 et al., , p.711, 2006.

, Regional white matter and neuropsychological functioning 712 across the adult lifespan, Biol Psychiatry, vol.60, pp.444-453

M. Tullberg, E. Fletcher, C. Decarli, D. Mungas, and B. R. Reed, , p.714

D. J. Harvey, M. W. Weiner, H. C. Chui, and W. J. Jagust, White 715 matter lesions impair frontal lobe function regardless of their 716 location, Neurology, vol.63, pp.246-253, 2004.

G. B. Frisoni, M. Lorenzi, A. Caroli, and N. Kemppainen, Nagren, vol.718

K. and R. Jo, In vivo mapping of amyloid toxicity in 719 Alzheimer disease, Neurology, vol.72, pp.1504-1511, 2009.

E. C. Mormino, J. T. Kluth, C. M. Madison, G. D. Rabinovici, S. L. Baker-721 et al., Episodic memory loss is related to hippocampal-723 mediated beta-amyloid deposition in elderly subjects, Jagust, vol.722, pp.1310-1323, 2009.

D. S. Knopman, C. R. Jack, J. Wiste, H. J. Weigand, S. D. Vemuri et al., , p.726

V. J. Lowe, K. Kantarci, J. L. Gunter, M. L. Senjem, and M. M. Mielke, , p.727

R. O. Roberts, B. F. Boeve, and R. C. Petersen, Brain injury 728 biomarkers are not dependent on beta-amyloid in normal 729 elderly, Ann Neurol, vol.73, pp.472-480, 2013.

M. Wirth, C. M. Madison, G. D. Rabinovici, H. Oh, and S. M. Landau, , p.731

W. J. Jagust, Alzheimer's disease neurodegenerative biomarkers are associated with decreased cognitive function 732, 2013.

, but not beta-amyloid in cognitively normal older individuals, p.733

, J Neurosci, vol.33

T. Den-heijer, F. Van-der-lijn, A. Ikram, P. J. Koudstaal, and . Van-der, , p.735

A. Lugt, G. P. Krestin, H. A. Vrooman, A. Hofman, and W. J. Niessen, , p.736

M. M. Breteler, Vascular risk factors, apolipoprotein E, p.737, 2012.

, and hippocampal decline on magnetic resonance imaging over 738 a 10-year follow-up, Alzheimers Dement, vol.8

M. Wirth, S. Villeneuve, C. M. Haase, and C. M. Madison,

S. M. Landau, G. D. Rabinovici, and W. J. Jagust, , p.741, 2013.

, Alzheimer disease biomarkers, neurodegeneration, p.742

, JAMA Neu-743 rol, vol.70, pp.1512-1519

J. Barnes, O. T. Carmichael, and K. K. Leung, , p.745

. Gr, J. W. Bartlett, I. B. Malone, J. M. Schott, and M. N. Rossor, , p.746

G. J. Sels, C. Decarli, and N. C. Fox, Vascular and Alzheimer's, p.747, 2013.

, Alzheimer's Disease Neuroimaging Initiative controls

, robiol Aging, vol.34, 1996.

V. A. Guzman, O. T. Carmichael, C. Schwarz, and G. Tosto,

M. E. Man and A. M. Brickman, , 2013.

A. Alonso, T. H. Mosley, J. Gottesman, R. F. Catellier, and D. ,

C. J. Ar, Risk of dementia hospitalisation asso-757, 2009.

, ciated with cardiovascular risk factors in midlife and older 758 age: The Atherosclerosis Risk in Communities (ARIC) study, p.759

, J Neurol Neurosurg Psychiatry, vol.80

H. Braak and E. Braak, Neuropathological stageing of, p.761, 1991.

, Alzheimer-related changes, Acta Neuropathol, vol.82, pp.239-259

D. Leys, J. P. Pruvo, M. Parent, P. Vermersch, and G. Soetaert,

M. Ling, A. Delacourte, A. Defossez, A. Rapoport, and C. J. ,

, Could Wallerian degeneration contribute to, 1991.

, araiosis" in subjects free of any vascular disorder, J Neurol, vol.766

, Neurosurg Psychiatry, vol.54

A. Costanza, A. Xekardaki, E. Kovari, and G. Gold,