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Trends in the incidence of dementia: design and methods in the Alzheimer Cohorts Consortium

Lori Chibnik 1, 2 Frank Wolters 1, 3 Kristoffer Bäckman 4 Alexa Beiser 5 Claudine Berr 6 Joshua Bis 7 Eric Boerwinkle 8 Daniel Bos 1, 3 Carol Brayne 9 Jean-François Dartigues 10 Sirwan Darweesh 1, 3 Stéphanie Debette 11 Kendra Davis-Plourde 12 Carole Dufouil 13 Myriam Fornage 14 Leslie Grasset 11 Vilmundur Gudnason 15 Christoforos Hadjichrysanthou 16 Catherine Helmer 10 M. Arfan Ikram 3 M. Kamran Ikram 3 Silke Kern 4 Lewis Kuller 17 Lenore Launer 18 Oscar López 19 Fiona Matthews 20 Osorio Meirelles 18 Thomas Mosley 21 Alison Ower 16 Bruce Psaty 22 Claudia Satizabal 23 Sudha Seshadri 23 Ingmar Skoog 24 Blossom Stephan 25 Christophe Tzourio 26 Reem Waziry 1 Mei Mei Wong 16 Anna Zettergren 4 Albert Hofman 1, 3, *
Abstract : Several studies have reported a decline in incidence of dementia which may have large implications for the projected burden of disease, and provide important guidance to preventive efforts. However, reports are conflicting or inconclusive with regard to the impact of gender and education with underlying causes of a presumed declining trend remaining largely unidentified. The Alzheimer Cohorts Consortium aggregates data from nine international population-based cohorts to determine changes in the incidence of dementia since 1990. We will employ Poisson regression models to calculate incidence rates in each cohort and Cox proportional hazard regression to compare 5-year cumulative hazards across study-specific epochs. Finally, we will meta-analyse changes per decade across cohorts, and repeat all analysis stratified by sex, education and APOE genotype. In all cohorts combined, there are data on almost 69,000 people at risk of dementia with the range of follow-up years between 2 and 27. The average age at baseline is similar across cohorts ranging between 72 and 77. Uniting a wide range of disease-specific and methodological expertise in research teams, the first analyses within the Alzheimer Cohorts Consortium are underway to tackle outstanding challenges in the assessment of time-trends in dementia occurrence.
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Lori Chibnik, Frank Wolters, Kristoffer Bäckman, Alexa Beiser, Claudine Berr, et al.. Trends in the incidence of dementia: design and methods in the Alzheimer Cohorts Consortium. European Journal of Epidemiology, Springer Verlag, 2017, 32 (10), pp.931-938. ⟨10.1007/s10654-017-0320-5⟩. ⟨inserm-02466417⟩

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