M. M. Breteler, Vascular risk factors for Alzheimer's disease: an epidemiologic perspective, Neurobiol Aging, vol.21, issue.2, pp.153-160, 2000.

L. J. Launer, G. W. Ross, and H. Petrovitch, Midlife blood pressure and dementia: the Honolulu-Asia Aging Study, Neurobiol Aging, vol.21, issue.1, pp.49-55, 2000.

R. A. Whitmer, S. Sidney, J. Selby, S. C. Johnston, and K. Yaffe, Midlife cardiovascular risk factors and risk of dementia in late life, Neurology, vol.64, issue.2, pp.277-281, 2005.

N. Qizilbash, J. Gregson, and M. E. Johnson, BMI and risk of dementia in two million people over two decades: a retrospective cohort study, Lancet Diabetes Endocrinol, vol.3, issue.6, pp.33-42, 2015.

R. F. Gottesman, M. S. Albert, and A. Alonso, Associations between midlife vascular risk factors and 25-year incident dementia in the Atherosclerosis

, JAMA Neurol, vol.74, issue.10, pp.1246-1254, 2017.

A. L. Fitzpatrick, L. H. Kuller, and O. L. Lopez, Midlife and late-life obesity and the risk of dementia: Cardiovascular Health Study, Arch Neurol, vol.66, issue.3, pp.336-342, 2009.

K. J. Anstey, N. Cherbuin, M. Budge, and J. Young, Body mass index in midlife and late-life as a risk factor for dementia: a meta-analysis of prospective studies, Obes Rev, vol.12, issue.5, pp.426-437, 2011.

R. F. Gottesman, A. Schneider, and Y. Zhou, Association between midlife vascular risk factors and estimated brain amyloid deposition, JAMA, vol.317, issue.14, pp.1443-1450, 2017.

C. Qiu, V. Strauss, E. Fastbom, J. Winblad, B. Fratiglioni et al., Low blood pressure and risk of dementia in the Kungsholmen Project: a 6-year follow-up study, Arch Neurol, vol.60, issue.2, pp.223-228, 2003.

I. Skoog, B. Lernfelt, and S. Landahl, 15-year longitudinal study of blood pressure and dementia, Lancet, vol.347, issue.9009, p.90608, 1996.

D. Gustafson, E. Rothenberg, K. Blennow, B. Steen, I. Skoog et al., An 18-year follow-up of overweight and risk of Alzheimer disease, Arch Intern Med, vol.163, issue.13, pp.540-548, 2003.

W. Xu, C. Qiu, M. Gatz, N. L. Pedersen, B. Johansson et al., Mid-and late-life diabetes in relation to the risk of dementia: a population-based twin study, Diabetes, vol.58, issue.1, pp.71-77, 2009.

G. Cheng, C. Huang, H. Deng, H. Wang, A. Singh-manoux et al., Diabetes as a risk factor for dementia and mild cognitive impairment: a meta-analysis of longitudinal studies, Alzheimers Dement, vol.42, issue.5, pp.178-186, 2012.

S. Sabia, A. Dugravot, and J. F. Dartigues, Physical activity, cognitive decline, and risk of dementia: 28 year follow-up of Whitehall II cohort study, BMJ, vol.357, p.2709, 2017.

H. Amieva, L. Goff, M. Millet, and X. , Prodromal Alzheimer's disease: successive emergence of the clinical symptoms, Ann Neurol, vol.64, issue.5, pp.492-498, 2008.

A. Singh-manoux, A. Dugravot, and A. Fournier, Trajectories of depressive symptoms before diagnosis of dementia: a 28-year follow-up study, JAMA Psychiatry, vol.74, issue.7, pp.712-718, 2017.

. Power, . Mc, J. Weuve, J. J. Gagne, M. B. Mcqueen et al., 3C Study Group. Vascular factors and risk of dementia: design of the Three-City Study and baseline characteristics of the study population, Neuroepidemiology, vol.22, issue.5, pp.316-325, 2003.

, World Health Organization. Guidelines for ATC Classification and DDD Assignment, p.30, 2002.

G. Mckhann, D. Drachman, M. Folstein, R. Katzman, D. Price et al., Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease, Neurology, vol.34, issue.7, pp.939-944, 1984.

J. M. Robins, M. H. Gail, and J. H. Lubin, More on "biased selection of controls for case-control analyses of cohort studies, Biometrics, vol.42, issue.2, pp.293-299, 1986.

W. T. Friedewald, R. I. Levy, and D. S. Fredrickson, Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge, Clin Chem, vol.18, issue.6, pp.499-502, 1972.

C. Proust-lima, H. Amieva, and H. Jacqmin-gadda, Analysis of multivariate mixed longitudinal data: a flexible latent process approach, Br J Math Stat Psychol, vol.66, issue.3, pp.470-487, 2013.

E. Bergstralh and J. Kosanke, Computerized matching of controls, Technical Report Series, Number, vol.56, 1995.

C. Proust-lima, V. Philipps, and B. Liquet, Estimation of extended mixed models using latent classes and latent processes: the R package lcmm, J Stat Softw, vol.78, issue.2, pp.1-56, 2017.
URL : https://hal.archives-ouvertes.fr/hal-01759902

A. Ferrara, E. Barrett-connor, and S. J. Total, LDL, and HDL cholesterol decrease with age in older men and women: the Rancho Bernardo Study 1984-1994, Circulation, vol.96, issue.1, pp.37-43, 1997.

P. W. Wilson, K. M. Anderson, T. Harris, W. B. Kannel, and W. P. Castelli, Determinants of change in total cholesterol and HDL-C with age: the Framingham Study, J Gerontol, vol.49, issue.6, pp.252-257, 1994.

T. P. Loh, S. Ma, D. Heng, C. Khoo, S. S. Franklin et al., Age-related changes in the cardiometabolic profiles in Singapore resident adult population: findings from the National Health Survey, Circulation, vol.11, issue.8, pp.308-315, 1997.

N. M. Van-popele, D. E. Grobbee, and M. L. Bots, Association between arterial stiffness and atherosclerosis: the Rotterdam Study, Stroke, vol.32, issue.2, pp.454-460, 2001.

M. L. Bots, J. C. Witteman, A. Hofman, P. T. De-jong, G. De-;-menke et al., Hemoglobin A1c, fasting plasma glucose, and 2-hour plasma glucose distributions in US population subgroups, Arch Intern Med, vol.156, issue.8, pp.2005-2010, 1996.

, Ann Epidemiol, vol.24, issue.2, pp.83-89, 2014.

C. Qiu, B. Winblad, and L. Fratiglioni, The age-dependent relation of blood pressure to cognitive function and dementia, Lancet Neurol, vol.4, issue.8, pp.487-499, 2005.

E. Szoke, M. Z. Shrayyef, and S. Messing, Effect of aging on glucose homeostasis: accelerated deterioration of beta-cell function in individuals with impaired glucose tolerance, Diabetes Care, vol.31, issue.3, pp.539-543, 2008.

D. K. Johnson, C. H. Wilkins, and J. C. Morris, Accelerated weight loss may precede diagnosis in Alzheimer disease, Arch Neurol, vol.63, issue.9, pp.1312-1317, 2006.

R. Stewart, K. Masaki, and Q. Xue, A 32-year prospective study of change in body weight and incident dementia: the Honolulu-Asia Aging Study, Arch Neurol, vol.62, issue.1, pp.55-60, 2005.

D. S. Knopman, S. D. Edland, R. H. Cha, R. C. Petersen, and W. A. Rocca, Incident dementia in women is preceded by weight loss by at least a decade

, Neurology, vol.69, issue.8, pp.739-746, 2007.

A. Ogunniyi, S. Gao, and F. W. Unverzagt, Weight loss and incident dementia in elderly Yoruba Nigerians: a 10-year follow-up study, Int Psychogeriatr, vol.23, issue.3, pp.387-394, 2011.

E. Barrett-connor, S. L. Edelstein, J. Corey-bloom, and W. C. Wiederholt, Weight loss precedes dementia in community-dwelling older adults, J Am Geriatr Soc, vol.44, issue.10, pp.1147-1152, 1996.

E. R. Mcgrath, A. S. Beiser, and C. Decarli, Blood pressure from mid-to late life and risk of incident dementia, Neurology, vol.89, issue.24, pp.2447-2454, 2017.

E. Joas, K. Bäckman, and D. Gustafson, Blood pressure trajectories from midlife to late life in relation to dementia in women followed for 37 years, Hypertension, vol.59, issue.4, pp.796-801, 2012.

R. Stewart, Q. Xue, and K. Masaki, Twenty-six-year change in total cholesterol levels and incident dementia: the Honolulu-Asia Aging Study, Hypertension, vol.54, issue.2, pp.103-107, 2007.

M. M. Mielke, P. P. Zandi, and H. Shao, The 32-year relationship between cholesterol and dementia from midlife to late life, Neurology, vol.75, issue.21, pp.1888-1895, 2010.

R. S. Wilson, S. E. Arnold, J. A. Schneider, Y. Tang, and D. A. Bennett, The relationship between cerebral Alzheimer's disease pathology and odour identification in old age, J Neurol Neurosurg Psychiatry, vol.78, issue.1, pp.30-35, 2007.

R. S. Wilson, S. E. Arnold, J. A. Schneider, P. A. Boyle, A. S. Buchman et al., Olfactory impairment in presymptomatic Alzheimer's disease, Ann N Y Acad Sci, vol.1170, pp.730-735, 2009.

K. Pérès, C. Helmer, and H. Amieva, Natural history of decline in instrumental activities of daily living performance over the 10 years preceding the clinical diagnosis of dementia: a prospective population-based study, J Am Geriatr Soc, vol.56, issue.1, pp.1053-1057, 2003.

W. J. Burke, P. G. Coronado, C. A. Schmitt, K. M. Gillespie, and H. D. Chung, Blood pressure regulation in Alzheimer's disease, J Auton Nerv Syst, vol.48, issue.1, pp.65-71, 1994.

C. Tzourio, S. Laurent, and S. Debette, Is hypertension associated with an accelerated aging of the brain?, Hypertension, vol.63, issue.5, pp.894-903, 2014.

. Strachan-mwj.-r-d-lawrence-lecture, the brain as a target organ in type 2 diabetes: exploring the links with cognitive impairment and dementia, Lancet Neurol, vol.28, issue.2, pp.70526-70535, 2006.

R. P. Gelber, J. M. Gaziano, E. J. Orav, J. E. Manson, J. E. Buring et al., Measures of obesity and cardiovascular risk among men and women, J Am Coll Cardiol, vol.52, issue.8, pp.605-615, 2008.