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Chromatin-bound MDM2, a new player in metabolism

Abstract : The oncoprotein MDM2 is recognized as a major negative regulator of the p53 tumor suppressor but growing evidence indicates that its oncogenic activities extend beyond p53. We show that MDM2 is recruited to chromatin independently of p53 to regulate a transcriptional program implicated in amino acid metabolism and redox homeostasis.
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Submitted on : Monday, February 3, 2020 - 5:40:56 PM
Last modification on : Wednesday, November 3, 2021 - 7:39:29 AM

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Romain Riscal, Laurent Le Cam, Laetitia Linares. Chromatin-bound MDM2, a new player in metabolism. Molecular & Cellular Oncology, Taylor et Francis, 2016, 3 (5), pp.e1210560. ⟨10.1080/23723556.2016.1210560⟩. ⟨inserm-02465279⟩



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