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Vitamin E transport, membrane incorporation and cell metabolism: Is α-tocopherol in lipid rafts an oar in the lifeboat?

Abstract : Vitamin E is composed of closely related compounds, including tocopherols and tocotrienols. Studies of the last decade provide strong support for a specific role of alpha-tocopherol in cell signalling and the regulation of gene expression. It produces significant effects on inflammation, cell proliferation and apoptosis that are not shared by other vitamin E isomers with similar antioxidant properties. The different behaviours of vitamin E isomers might relate, at least in part, to the specific effects they exert at the plasma membrane. alpha-Tocopherol is not randomly distributed throughout the phospholipid bilayer of biological membranes, and as compared with other isomers, it shows a propensity to associate with lipid rafts. Distinct aspects of vitamin E transport and metabolism is discussed with emphasis on the interaction between alpha-tocopherol and lipid rafts and the consequences of these interactions on cell metabolism.
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https://www.hal.inserm.fr/inserm-02462984
Contributor : Catherine Desrumaux <>
Submitted on : Friday, January 31, 2020 - 4:01:25 PM
Last modification on : Saturday, February 1, 2020 - 1:23:20 AM

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Stéphanie Lemaire-Ewing, Catherine Desrumaux, Dominique Néel, Laurent Lagrost. Vitamin E transport, membrane incorporation and cell metabolism: Is α-tocopherol in lipid rafts an oar in the lifeboat?. Molecular Nutrition and Food Research, Wiley-VCH Verlag, 2010, 54 (5), pp.631-640. ⟨10.1002/mnfr.200900445⟩. ⟨inserm-02462984⟩

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