 |
Journal articles
Plasma Phospholipid Transfer Protein Deficiency in Mice Is Associated With a Reduced Thrombotic Response to Acute Intravascular Oxidative Stress
Catherine Desrumaux
1
Valérie Deckert
1
Stéphanie Lemaire-Ewing
1, 2
Anne Athias
1
David Vandroux
2
Laure Dumont
2
Serge Monier
1
Jean-Paul Pais de Barros
1
Alexis Klein
1
Emmanuel de Maistre
2
Denis Blache
1
Alain Beley
3
Christine Marie
3
Philippe Garnier
3
Laurent Lagrost
1, 2
Claude Mossiat
4, 3
Catherine C. Desrumaux 1
Author IdHAL : catherine-desrumaux IdRef : https://www.idref.fr/184451094
Valérie Deckert 1
Author
Stéphanie Lemaire-Ewing 1, 2
Author
Anne Athias 1
Author
David Vandroux 2
Author
Laure Dumont 2
Author
Serge Monier 1
Author
Jean-Paul Pais de Barros 1
Author
Christine Marie 3
Author
Philippe Garnier 3
Author
Laurent Lagrost 1, 2
Author
Claude Mossiat 4, 3
Author
1
LNC - Lipides - Nutrition - Cancer (U866) (Université de Bourgogne - Faculte de medecine - 7, boulevard Jeanne d'Arc - BP 87900 - 21079 Dijon Cedex - France)
- UB - Université de Bourgogne (Maison de l'université - Esplanade Érasme - BP 27877 - 21078 Dijon cedex - France)
- INSERM - Institut National de la Santé et de la Recherche Médicale : U866 (101, rue de Tolbiac, 75013 Paris - France)
- AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement : U866 (26 Boulevard du Dr Petitjean - BP 87999 - 21079 Dijon cedex - France)
- ENSBANA - Ecole Nationale Supérieure de Biologie Appliquée à la Nutrition et à l'Alimentation de Dijon : U866 (Campus de Montmuzard, 21100 Dijon - France)
2
Hôpital du Bocage (2, boulevard Maréchal-de-Lattre-de-Tassigny, 21000 Dijon - France)
- CHU Dijon - Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand (CHU Dijon - 14 rue Paul Gaffarel - 21079 Dijon - France)
3
Motricité - Plasticité (Université de Bourgogne - 21000 Dijon - France)
- UB - Université de Bourgogne (Maison de l'université - Esplanade Érasme - BP 27877 - 21078 Dijon cedex - France)
- INSERM - Institut National de la Santé et de la Recherche Médicale : U887 (101, rue de Tolbiac, 75013 Paris - France)
4
UB - Université de Bourgogne (Maison de l'université - Esplanade Érasme - BP 27877 - 21078 Dijon cedex - France)
Abstract : OBJECTIVE:
Earlier in vitro studies suggested a putative role for the plasma phospholipid transfer protein (PLTP) in the modulation of blood coagulation. The effect of PLTP expression on blood coagulation under both basal and oxidative stress conditions was compared here in wild-type and PLTP-deficient (PLTP-/-) mice.
METHODS AND RESULTS:
Under basal conditions, PLTP deficiency was associated with an extended tail bleeding time despite a significant depletion of vascular α-tocopherol content and an impairment of endothelial function. When acute oxidative stress was generated in vivo in the brain vasculature, the steady state levels of oxidized lipid derivatives, the extent of blood vessel occlusion, and the volume of ischemic lesions were more severe in wild-type than in PLTP-/- mice.
CONCLUSIONS:
In addition to its recognized hyperlipidemic, proinflammatory, and proatherogenic properties, PLTP increases blood coagulation and worsens the extent of ischemic lesions in response to acute oxidative stress. Thus, PLTP arises here as a cardiovascular risk factor for the late thrombotic events occurring in the acute phase of atherosclerosis
Document type :
Journal articles
Domain :
Complete list of metadata
https://www.hal.inserm.fr/inserm-02462980
Contributor : Catherine Desrumaux <>
Submitted on : Tuesday, February 4, 2020 - 12:38:16 PM
Last modification on : Friday, February 7, 2020 - 1:26:52 AM
Contributor : Catherine Desrumaux <>
Submitted on : Tuesday, February 4, 2020 - 12:38:16 PM
Last modification on : Friday, February 7, 2020 - 1:26:52 AM
Links full text
Identifiers
- HAL Id : inserm-02462980, version 1
- DOI : 10.1161/ATVBAHA.110.207654
- PUBMED : 20864671
Collections
Citation
Catherine Desrumaux, Valérie Deckert, Stéphanie Lemaire-Ewing, Anne Athias, David Vandroux, et al.. Plasma Phospholipid Transfer Protein Deficiency in Mice Is Associated With a Reduced Thrombotic Response to Acute Intravascular Oxidative Stress. Arteriosclerosis, Thrombosis, and Vascular Biology, American Heart Association, 2010, 30 (12), pp.2452-2457. ⟨10.1161/ATVBAHA.110.207654⟩. ⟨inserm-02462980⟩