J. Landry, D. L. Mager, and B. T. Wilhelm, Complex controls: the role of alternative promoters in mammalian genomes, Trends Genet. TIG, vol.19, pp.640-648, 2003.

K. Golovine, M. Schwerin, and J. Vanselow, Three different promoters control expression of the aromatase cytochrome p450 gene (cyp19) in mouse gonads and brain, Biol. Reprod, vol.68, pp.978-984, 2003.

Y. X. Pan, Generation of the mu opioid receptor (MOR-1) protein by three new splice variants of the Oprm gene, Proc. Natl. Acad. Sci. USA, vol.98, pp.14084-14089, 2001.

L. M. Pardo, Regional differences in gene expression and promoter usage in aged human brains, Neurobiol. Aging, vol.34, pp.1825-1836, 2013.

T. Chen, Y. Ueda, S. Xie, and E. Li, A novel Dnmt3a isoform produced from an alternative promoter localizes to euchromatin and its expression correlates with active de novo methylation, J. Biol. Chem, vol.277, pp.38746-38754, 2002.

A. Saleh, A. P. Makrigiannis, D. L. Hodge, and S. K. Anderson, Identification of a novel Ly49 promoter that is active in bone marrow and fetal thymus, J. Immunol. Baltim. Md, vol.168, pp.5163-5169, 1950.

A. C. Mcmahon, SynGAP isoforms exert opposing effects on synaptic strength, Nat. Commun, vol.3, p.900, 2012.

N. A. Twine, K. Janitz, M. R. Wilkins, and M. Janitz, Whole transcriptome sequencing reveals gene expression and splicing differences in brain regions affected by Alzheimer's disease, PloS One, vol.6, p.16266, 2011.

P. Renbaum, Egr-1 upregulates the Alzheimer's disease presenilin-2 gene in neuronal cells, Gene, vol.318, pp.113-124, 2003.

H. Ounallah-saad, Transcriptional regulation of the murine Presenilin-2 gene reveals similarities and differences to its human orthologue, Gene, vol.446, pp.81-89, 2009.

A. Andreadis, Tau gene alternative splicing: expression patterns, regulation and modulation of function in normal brain and neurodegenerative diseases, Biochim. Biophys. Acta, vol.1739, pp.91-103, 2005.

N. Sergeant, A. Delacourte, and L. Buée, Tau protein as a differential biomarker of tauopathies, Biochim. Biophys. Acta, vol.1739, pp.179-197, 2005.

V. Huin, The MAPT gene is differentially methylated in the progressive supranuclear palsy brain, Mov. Disord. Off. J. Mov. Disord. Soc, vol.31, pp.1883-1890, 2016.

M. Caillet-boudin, L. Buée, N. Sergeant, and B. Lefebvre, Regulation of human MAPT gene expression, Mol. Neurodegener, vol.10, p.28, 2015.

A. Andreadis, B. K. Wagner, J. A. Broderick, and K. S. Kosik, A tau promoter region without neuronal specificity, J. Neurochem, vol.66, pp.2257-2263, 1996.

Z. Deng, P. Cao, M. M. Wan, and G. Sui, Yin Yang 1: a multifaceted protein beyond a transcription factor, Transcription, vol.1, pp.81-84, 2010.

B. Borowsky and B. J. Hoffman, Analysis of a gene encoding two glycine transporter variants reveals alternative promoter usage and a novel gene structure, J. Biol. Chem, vol.273, pp.29077-29085, 1998.

T. Udono, Structural organization of the human microphthalmia-associated transcription factor gene containing four alternative promoters, Biochim. Biophys. Acta, vol.1491, pp.205-219, 2000.

A. Okbay, Genome-wide association study identifies 74 loci associated with educational attainment, Nature, vol.533, pp.539-542, 2016.
URL : https://hal.archives-ouvertes.fr/hal-02017372

K. G. Coupland, DNA methylation of the MAPT gene in Parkinson's disease cohorts and modulation by vitamin Ein vitro, Mov. Disord. Off. J. Mov. Disord. Soc, vol.29, pp.1606-1614, 2014.

K. G. Coupland, Role of the Long Non-Coding RNA MAPT-AS1 in Regulation of Microtubule Associated Protein Tau (MAPT) Expression in Parkinson's Disease, PloS One, vol.11, p.157924, 2016.

Y. Li, An epigenetic signature in peripheral blood associated with the haplotype on 17q21.31, a risk factor for neurodegenerative tauopathy, PLoS Genet, vol.10, p.1004211, 2014.

R. A. Rissman, Caspase-cleavage of tau is an early event in Alzheimer disease tangle pathology, J. Clin. Invest, vol.114, pp.121-130, 2004.

A. De-calignon, Caspase activation precedes and leads to tangles, Nature, vol.464, pp.1201-1204, 2010.

S. Matsumoto, The twenty-four KDa C-terminal tau fragment increases with aging in tauopathy mice: implications of prionlike properties, Hum. Mol. Genet, vol.24, pp.6403-6416, 2015.

N. Zilka, Truncated tau from sporadic Alzheimer's disease suffices to drive neurofibrillary degeneration in vivo, FEBS Lett, vol.580, pp.3582-3588, 2006.

P. Filipcik, First transgenic rat model developing progressive cortical neurofibrillary tangles, Neurobiol. Aging, vol.33, pp.1448-1456, 2012.

Y. P. Wang, J. Biernat, M. Pickhardt, E. Mandelkow, and E. Mandelkow, Stepwise proteolysis liberates tau fragments that nucleate the Alzheimer-like aggregation of full-length tau in a neuronal cell model, Proc. Natl. Acad. Sci. USA, vol.104, pp.10252-10257, 2007.

S. Wray, M. Saxton, B. H. Anderton, and D. P. Hanger, Direct analysis of tau from PSP brain identifies new phosphorylation sites and a major fragment of N-terminally cleaved tau containing four microtubule-binding repeats, J. Neurochem, vol.105, pp.2343-2352, 2008.

D. P. Hanger and S. Wray, Tau cleavage and tau aggregation in neurodegenerative disease, Biochem. Soc. Trans, vol.38, pp.1016-1020, 2010.

M. Derisbourg, Role of the Tau N-terminal region in microtubule stabilization revealed by new endogenous truncated forms, Sci. Rep, vol.5, p.9659, 2015.
URL : https://hal.archives-ouvertes.fr/hal-01659458

A. Pecci, L. R. Viegas, J. L. Baranao, and M. Beato, Promoter choice influences alternative splicing and determines the balance of isoforms expressed from the mouse bcl-X gene, J. Biol. Chem, vol.276, pp.21062-21069, 2001.

E. Logette, The human caspase-2 gene: alternative promoters, pre-mRNA splicing and AUG usage direct isoform-specific expression, Oncogene, vol.22, pp.935-946, 2003.

G. Nogues, S. Kadener, P. Cramer, D. Bentley, and A. R. Kornblihtt, Transcriptional activators differ in their abilities to control alternative splicing, J. Biol. Chem, vol.277, pp.43110-43114, 2002.

D. Auboeuf, Differential recruitment of nuclear receptor coactivators may determine alternative RNA splice site choice in target genes, Proc. Natl. Acad. Sci. USA, vol.101, pp.2270-2274, 2004.

S. Kadener, J. P. Fededa, M. Rosbash, and A. R. Kornblihtt, Regulation of alternative splicing by a transcriptional enhancer through RNA pol II elongation, Proc. Natl. Acad. Sci. USA, vol.99, pp.8185-8190, 2002.

P. Cramer, Coupling of transcription with alternative splicing: RNA pol II promoters modulate SF2/ASF and 9G8 effects on an exonic splicing enhancer, Mol. Cell, vol.4, pp.251-258, 1999.

R. V. Davuluri, Y. Suzuki, S. Sugano, C. Plass, and T. H. Huang, The functional consequences of alternative promoter use in mammalian genomes, Trends Genet. TIG, vol.24, pp.167-177, 2008.

M. Montes, S. Becerra, M. Sánchez-Álvarez, and C. Suñé, Functional coupling of transcription and splicing, Gene, vol.501, pp.104-117, 2012.

J. Schindelin, Fiji: an open-source platform for biological-image analysis, Nat. Methods, vol.9, pp.676-682, 2012.