L. E. Heasley, Autocrine and paracrine signaling through neuropeptide receptors in human cancer, Oncogene, vol.20, pp.1563-1569, 2001.

S. Vogt, R. Grosse, G. Schultz, and S. Offermanns, Receptordependent RhoA activation in G12/G13-deficient cells: genetic evidence for an involvement of Gq/G11, J. Biol. Chem, vol.278, pp.28743-28749, 2003.

A. B. Jaffe and A. Hall, Rho GTPases in transformation and metastasis, Adv. Cancer Res, vol.84, pp.57-80, 2002.

E. Lozano, M. Betson, and V. M. Braga, Tumor progression: small GTPases and loss of cell-cell adhesion, Bioessays, vol.25, pp.452-463, 2003.

Q. D. Nguyen, S. Faivre, E. Bruyneel, C. Rivat, M. Seto et al., RhoA-and RhoDdependent regulatory switch of Galpha subunit signaling by PAR-1 receptors in cellular invasion, FASEB J, vol.16, pp.565-576, 2002.

M. Najimi, J. M. Maloteaux, and E. Hermans, Cytoskeleton-related trafficking of the EAAC1 glutamate transporter after activation of the G(q/11)-coupled neurotensin receptor NTS1, FEBS Lett, vol.523, pp.224-228, 2002.

D. Zhao, S. Kuhnt-moore, H. Zeng, J. S. Wu, M. P. Moyer et al., Neurotensin stimulates IL-8 expression in human colonic epithelial cells through Rho GTPase-mediated NF-kappa B pathways, Am. J. Physiol. Cell Physiol, vol.284, pp.1397-1404, 2003.

J. Leyton, L. Garcia-marin, R. T. Jensen, and T. W. Moody, Neurotensin causes tyrosine phosphorylation of focal adhesion kinase in lung cancer cells, Eur. J. Pharmacol, vol.442, pp.179-186, 2002.

M. Reinecke, Neurotensin. Immunohistochemical localization in central and peripheral nervous system and in endocrine cells and its functional role as neurotransmitter and endocrine hormone, Prog. Histochem. Cytochem, vol.16, pp.1-172, 1985.

E. J. Draviam, J. R. Upp, . Jr, G. H. Greeley, . Jr et al., Effect of oral fat on plasma levels of neurotensin and neurotensin fragments in humans. Characterization by high-pressure liquid chromatography, Dig. Dis. Sci, vol.35, pp.200-204, 1990.

E. Giovannucci, Modifiable risk factors for colon cancer, Gastroenterol. Clin. North Am, vol.31, pp.925-943, 2002.

R. P. Thomas, M. R. Hellmich, C. M. Townsend, J. Evers, and B. M. , Role of gastrointestinal hormones in the proliferation of normal and neoplastic tissues, Endocr. Rev, vol.24, pp.571-599, 2003.

J. J. Maoret, Y. Anini, C. Rouyer-fessard, D. Gully, and M. Laburthe, Neurotensin and a non-peptide neurotensin receptor antagonist control human colon cancer cell growth in cell culture and in cells xenografted into nude mice, Int. J. Cancer, vol.80, pp.448-454, 1999.

T. W. Moody, J. Chiles, M. Casibang, E. Moody, D. Chan et al., SR48692 is a neurotensin receptor antagonist which inhibits the growth of small cell lung cancer cells, Peptides, vol.22, pp.109-115, 2001.

J. J. Maoret, D. Pospai, C. Rouyer-fessard, A. Couvineau, C. Laboisse et al., Neurotensin receptor and its mRNA are expressed in many human colon cancer cell lines but not in normal colonic epithelium: binding studies and RT-PCR experiments, Biochem. Biophys. Res. Commun, vol.203, pp.465-471, 1994.

K. W. Kinzler and B. Vogelstein, NT1 receptor gene as a Tcf/b-catenin target, vol.87, pp.159-170, 1996.

P. J. Morin, A. B. Sparks, V. Korinek, N. Barker, H. Clevers et al., Activation of beta-catenin-Tcf signaling in colon cancer by mutations in beta-catenin or APC, Science, vol.275, pp.1787-1790, 1997.

J. H. Van-es, N. Barker, and H. Clevers, You Wnt some, you lose some: oncogenes in the Wnt signaling pathway, Curr. Opin. Genet. Dev, vol.13, pp.28-33, 2003.

M. C. Faux, J. L. Ross, C. Meeker, T. Johns, H. Ji et al., Restoration of full-length adenomatous polyposis coli (APC) protein in a colon cancer cell line enhances cell adhesion, J. Cell. Sci, vol.117, pp.427-439, 2004.

A. Gompel, C. Malet, P. Spritzer, J. P. Lalardrie, F. Kuttenn et al., Progestin effect on cell proliferation and 17 betahydroxysteroid dehydrogenase activity in normal human breast cells in culture, J. Clin. Endocrinol. Metab, vol.63, pp.1174-1180, 1986.

J. Sambrook, E. F. Fritsch, and T. Maniatis, Molecular Cloning: A Laboratory Manual, 2nd Edn, 1989.

V. Korinek, N. Barker, P. J. Morin, D. Van-wichen, R. De-weger et al., Constitutive transcriptional activation by a beta-catenin-Tcf complex in APC-/-colon carcinoma, Science, vol.275, pp.1784-1787, 1997.

M. Therrien and J. Drouin, Cell-specific helix-loop-helix factor required for pituitary expression of the pro-opiomelanocortin gene, Mol. Cell. Biol, vol.13, pp.2342-2353, 1993.

F. Souaze, W. Rostene, and P. Forgez, Neurotensin agonist induces differential regulation of neurotensin receptor mRNA. Identification of distinct transcriptional and post-transcriptional mechanisms, J. Biol. Chem, vol.272, pp.10087-10094, 1997.
URL : https://hal.archives-ouvertes.fr/inserm-02459623

L. K. Su, B. Vogelstein, and K. W. Kinzler, Association of the APC tumor suppressor protein with catenins, Science, vol.262, pp.1734-1737, 1993.

H. Boudin, A. Grauz-guyon, M. P. Faure, P. Forgez, A. M. Lhiaubet et al., Immunological recognition of different forms of the neurotensin receptor in transfected cells and rat brain, Biochem. J, vol.305, pp.277-283, 1995.

M. P. Kurnellas, A. Nicot, G. E. Shull, and S. Elkabes, Plasma membrane calcium ATPase deficiency causes neuronal pathology in the spinal cord: a potential mechanism for neurodegeneration in multiple sclerosis and spinal cord injury, FASEB J, vol.19, pp.298-300, 2005.

M. E. Bracke, T. Boterberg, E. A. Bruyneel, and M. M. Mareel, Collagen invasion assay, Cell Behavior in Vitro and in Vivo, vol.58, pp.81-89, 2000.

F. Jourdan, N. Sebbagh, E. Comperat, N. Mourra, A. Flahault et al., Tissue microarray technology: validation in colorectal carcinoma and analysis of p53, hMLH1, and hMSH2 immunohistochemical expression, Virchows Arch, vol.443, pp.115-121, 2003.

T. Cagatay and M. Ozturk, P53 mutation as a source of aberrant beta-catenin accumulation in cancer cells, Oncogene, vol.21, pp.7971-7980, 2002.

F. Le, K. Groshan, X. P. Zeng, and E. Richelson, Characterization of the genomic structure, promoter region, and a tetranucleotide repeat polymorphism of the human neurotensin receptor gene, J. Biol. Chem, vol.272, pp.1315-1322, 1997.

T. Brabletz, A. Jung, K. Hermann, K. Gunther, W. Hohenberger et al., Nuclear overexpression of the oncoprotein beta-catenin in colorectal cancer is localized predominantly at the invasion front, Pathol. Res. Pract, vol.194, pp.701-704, 1998.

M. Miyaki, T. Iijima, J. Kimura, M. Yasuno, T. Mori et al., Frequent mutation of beta-catenin and APC genes in primary colorectal tumors from patients with hereditary nonpolyposis colorectal cancer, Cancer Res, vol.59, pp.4506-4509, 1999.

R. Fodde, R. Smits, and H. Clevers, APC, signal transduction and genetic instability in colorectal cancer, Nat. Rev. Cancer, vol.1, pp.55-67, 2001.

M. Van-de-wetering, E. Sancho, and C. Verweij, The beta-catenin/ TCF-4 complex imposes a crypt progenitor phenotype on colorectal cancer cells, Cell, vol.111, pp.241-250, 2002.

S. Guha, O. Rey, and E. Rozengurt, Neurotensin induces protein kinase C-dependent protein kinase D activation and DNA synthesis in human pancreatic carcinoma cell line PANC-1, Cancer Res, vol.62, pp.1632-1640, 2002.

K. Kisfalvi, S. Guha, and E. Rozengurt, Neurotensin and EGF induce synergistic stimulation of DNA synthesis by increasing the duration of ERK signaling in ductal pancreatic cancer cells, J. Cell. Physiol, vol.202, pp.880-890, 2005.

S. Somai, A. Gompel, W. Rostene, and P. Forgez, Neurotensin counteracts apoptosis in breast cancer cells, Biochem. Biophys. Res. Commun, vol.295, pp.482-488, 2002.

L. Gullo, R. Pezzilli, P. Tomassetti, and R. P. De-giorgio, Plasma cholecystokinin and neurotensin after an ordinary meal in humans. A prolonged time study, Gastroenterol. Clin. Biol, vol.22, pp.25-28, 1998.

N. A. Banker, M. R. Hellmich, H. J. Kim, C. M. Townsend, J. Evers et al., Src-mediated activation of the human neurotensin/ neuromedin N promoter, Surgery, vol.122, pp.180-185, 1997.

B. M. Evers, Z. Zhou, P. Celano, and J. Li, The neurotensin gene is a downstream target for Ras activation, J. Clin. Invest, vol.95, pp.2822-2830, 1995.

F. M. Giardiello, S. R. Hamilton, A. J. Krush, S. Piantadosi, L. M. Hylind et al., Treatment of colonic and rectal adenomas with sulindac in familial adenomatous polyposis, N. Engl. J. Med, vol.328, pp.1313-1316, 1993.

G. Steinbach, P. M. Lynch, and R. K. Phillips, The effect of celecoxib, a cyclooxygenase-2 inhibitor, in familial adenomatous polyposis, N. Engl. J. Med, vol.342, pp.1946-1952, 2000.

I. Castagliuolo, C. C. Wang, L. Valenick, A. Pasha, S. Nikulasson et al., Neurotensin is a proinflammatory neuropeptide in colonic inflammation, J. Clin. Invest, vol.103, pp.843-849, 1999.

D. Zhao, Y. Zhan, H. Zeng, H. W. Koon, M. P. Moyer et al., Neurotensin stimulates interleukin-8 expression through modulation of I{kappa}B{alpha} phosphorylation and p65 transcriptional activity, 2005.

, Mol. Pharmacol, vol.67, pp.2025-2031

D. Zhao, Y. Zhan, H. W. Koon, H. Zeng, S. Keates et al., Metalloproteinase-dependent transforming growth factor-alpha release mediates neurotensin-stimulated MAP kinase activation in human colonic epithelial cells, J. Biol. Chem, vol.279, pp.43547-43554, 2004.

P. Brun, C. Mastrotto, E. Beggiao, A. Stefani, L. Barzon et al., Neuropeptide neurotensin stimulates intestinal wound healing following chronic intestinal inflammation, Am. J. Physiol. Gastrointest. Liver Physiol, vol.288, pp.621-629, 2005.