M. D. Althuis, J. M. Dozier, W. F. Anderson, S. S. Devesa, and L. A. Brinton, Global trends in breast cancer incidence and mortality 1973-1997, Int J Epidemiol, vol.34, pp.405-417, 2005.

, Early Breast Cancer Trialists' Collaborative Group. Polychemotherapy for early breast cancer: an overview of the randomised trials, Lancet, vol.352, pp.930-972, 1998.

, Early Breast Cancer Trialists' Collaborative Group. Tamoxifen for early breast cancer: an overview of the randomised trials, Lancet, vol.351, pp.1451-67, 1998.

A. Borg, A. K. Tandon, and H. Sigurdsson, HER-2/neu amplification predicts poor survival in node-positive breast cancer, Cancer Res, vol.50, pp.4332-4339, 1990.

C. H. Yeon and M. D. Pegram, Anti-erbB-2 antibody trastuzumab in the treatment of HER2-amplified breast cancer, Invest New Drugs, vol.23, pp.391-409, 2005.

Y. Yarden and M. X. Sliwkowski, Untangling the ErbB signalling network, Nat Rev Mol Cell Biol, vol.2, pp.127-164, 2001.

C. Lebedis, K. Chen, L. Fallavollita, T. Boutros, and P. Brodt, Peripheral lymph node stromal cells can promote growth and tumorigenicity of breast carcinoma cells through the release of IGF-I and EGF, Int J Cancer, vol.100, pp.2-8, 2002.

K. L. Pierce, L. M. Luttrell, and R. J. Lefkowitz, New mechanisms in heptahelical receptor signaling to mitogen activated protein kinase cascades, Oncogene, vol.20, pp.1532-1541, 2001.

M. J. Marinissen and J. S. Gutkind, G-protein-coupled receptors and signaling networks: emerging paradigms, Trends Pharmacol Sci, vol.22, pp.368-76, 2001.

E. Rozengurt, Neuropeptides as growth factors for normal and cancerous cells, Trends Endocrinol Metab, vol.13, pp.128-162, 2002.

R. P. Thomas, M. R. Hellmich, C. M. Townsend, J. Evers, and B. M. , Role of gastrointestinal hormones in the proliferation of normal and neoplastic tissues, Endocr Rev, vol.24, pp.571-99, 2003.

S. Somai, A. Gompel, W. Rostene, and P. Forgez, Neurotensin counteracts apoptosis in breast cancer cells, Biochem Biophys Res Commun, vol.295, pp.482-490, 2002.

F. Souaze, V. Viardot-foucault, and N. Roullet, Neurotensin receptor 1 gene activation by the Tcf/ h-catenin pathway is an early event in human colonic adenomas, Carcinogenesis, vol.27, pp.708-724, 2006.

B. M. Tyler-mcmahon, M. Boules, and E. Richelson, Neurotensin: peptide for the next millennium, Regul Pept, vol.93, pp.125-161, 2000.

D. Gully, M. Canton, and R. Boigegrain, Biochemical and pharmacological profile of a potent and selective nonpeptide antagonist of the neurotensin receptor, Proc Natl Acad Sci, vol.90, pp.65-74, 1993.

M. Reinecke and . Neurotensin, Immunohistochemical localization in central and peripheral nervous system and in endocrine cells and its functional role as neurotransmitter and endocrine hormone, Prog Histochem Cytochem, vol.16, pp.1-172, 1985.

L. Gullo, R. Pezzilli, P. Tomassetti, and R. De-giorgio, Plasma cholecystokinin and neurotensin after an ordinary meal in humans. A prolonged time study717, Gastroenterol Clin Biol, vol.22, pp.25-33, 1998.

I. Baca, G. E. Feurle, A. Schwab, U. Mittmann, W. Knauf et al., Effect of neurotensin on exocrine pancreatic secretion in dogs, Digestion, vol.23, pp.174-83, 1982.

S. Andersson, S. Rosell, U. Hjelmquist, D. Chang, and K. Folkers, Inhibition of gastric and intestinal motor activity in dogs by (Gln4) neurotensin, Acta Physiol Scand, vol.100, pp.231-236, 1977.

M. J. Armstrong, M. C. Parker, C. F. Ferris, and S. E. Leeman, Neurotensin stimulates [3H]oleic acid translocation across rat small intestine, Am J Physiol, vol.251, pp.823-832, 1986.

J. Elek, W. Pinzon, K. H. Park, and R. Narayanan, Relevant genomics of neurotensin receptor in cancer, Anticancer Res, vol.20, pp.53-61, 2000.

L. Wang, H. Friess, and Z. Zhu, Neurotensin receptor-1 mRNA analysis in normal pancreas and pancreatic disease, Clin Cancer Res, vol.6, pp.566-71, 2000.

D. Zhao, S. Kuhnt-moore, H. Zeng, J. S. Wu, M. P. Moyer et al., Neurotensin stimulates IL-8 expression in human colonic epithelial cells through Rho GTPasemediated NF-nB pathways, Am J Physiol Cell Physiol, vol.284, pp.1397-404, 2003.

J. Leyton, L. Garcia-marin, R. T. Jensen, and T. W. Moody, Neurotensin causes tyrosine phosphorylation of focal adhesion kinase in lung cancer cells, Eur J Pharmacol, vol.442, pp.179-86, 2002.

R. A. Ehlers, Y. Zhang, M. R. Hellmich, and B. M. Evers, Neurotensin-mediated activation of MAPK pathways and AP-1 binding in the human pancreatic cancer cell line, MIA PaCa-2, Biochem Biophys Res Commun, vol.269, pp.704-712, 2000.

S. Hassan, P. R. Dobner, and R. E. Carraway, Involvement of MAP-kinase, PI3-kinase and EGF-receptor in the stimulatory effect of Neurotensin on DNA synthesis in PC3 cells, Regul Pept, vol.120, pp.155-66, 2004.

D. Zhao, Y. Zhan, and H. W. Koon, Metalloproteinasedependent transforming growth factor-a release mediates neurotensin-stimulated MAP kinase activation in human colonic epithelial cells, J Biol Chem, vol.279, pp.43547-54, 2004.

A. Gompel, C. Malet, P. Spritzer, J. P. Lalardrie, F. Kuttenn et al., Progestin effect on cell proliferation and 17h-hydroxysteroid dehydrogenase activity in normal human breast cells in culture, J Clin Endocrinol Metab, vol.63, pp.1174-80, 1986.

H. Bloom and W. W. Richardson, Histological grading and prognosis in breast cancer, Br J Cancer, vol.3, pp.359-77, 1957.

F. Souaze, W. Rostene, and P. Forgez, Neurotensin agonist induces differential regulation of neurotensin receptor mRNA. Identification of distinct transcriptional and post-transcriptional mechanisms, J Biol Chem, vol.272, pp.10087-94, 1997.
URL : https://hal.archives-ouvertes.fr/inserm-02459623

M. Bracke, T. Boterberg, E. Bruyneel, and M. Mareel, Collagen invasion assay, Cancer invasion and metastasis, pp.81-90, 2000.

B. S. Nielsen, M. Sehested, L. Kjeldsen, N. Borregaard, J. Rygaard et al., Expression of matrix metalloprotease-9 in vascular pericytes in human breast cancer, Lab Invest, vol.77, pp.345-55, 1997.

A. Scorilas, A. Karameris, and N. Arnogiannaki, Overexpression of matrix-metalloproteinase-9 in human breast cancer: a potential favourable indicator in nodenegative patients, Br J Cancer, vol.84, pp.1488-96, 2001.

K. Nabeshima, T. Inoue, Y. Shimao, and T. Sameshima, Matrix metalloproteinases in tumor invasion: role for cell migration, Pathol Int, vol.52, pp.255-64, 2002.

J. I. Levin, J. M. Chen, and M. T. Du, The discovery of anthranilic acid-based MMP inhibitors. Part 3. Incorporation of basic amines, Bioorg Med Chem Lett, vol.11, pp.2975-2983, 2001.

L. R. Howe and A. M. Brown, Wnt signaling and breast cancer, Cancer Biol Ther, vol.3, pp.36-41, 2004.

M. Toy-miou-leong, C. L. Cortes, A. Beaudet, W. Rostene, and P. Forgez, Receptor trafficking via the perinuclear recycling compartment accompanied by cell division is necessary for permanent neurotensin cell sensitization and leads to chronic mitogen-activated protein kinase activation, J Biol Chem, vol.279, pp.12636-12682, 2004.

B. M. Evers, Z. Zhou, V. Dohlen, S. Rajaraman, J. C. Thompson et al., Fetal and neoplastic expression of the neurotensin gene in the human colon, Ann Surg, vol.223, pp.464-70, 1996.

K. Calhoun, S. Toth-fejel, J. Cheek, and R. Pommier, Serum peptide profiles in patients with carcinoid tumors, Am J Surg, vol.186, pp.28-31, 2003.

E. Theodorsson-norheim, K. Oberg, S. Rosell, and H. Bostrom, Neurotensinlike immunoreactivity in plasma and tumor tissue from patients with endocrine tumors of the pancreas and gut, Gastroenterology, vol.85, pp.881-890, 1983.

Z. Dong, X. Wang, and B. M. Evers, Site-specific DNA methylation contributes to neurotensin/neuromedin N expression in colon cancers, Am J Physiol Gastrointest Liver Physiol, vol.279, pp.1139-1186, 2000.

B. M. Evers, Endocrine gene neurotensin: molecular mechanisms and a model of intestinal differentiation, World J Surg, vol.26, pp.799-805, 2002.

J. J. Watters and D. M. Dorsa, Transcriptional effects of estrogen on neuronal neurotensin gene expression involve cAMP/protein kinase A-dependent signaling mechanisms, J Neurosci, vol.18, pp.6672-80, 1998.

D. M. Goettler, L. Levin, and W. Y. Chey, Postprandial levels of prolactin and gut hormones in breast cancer patients: association with stage of disease, but not dietary fat, J Natl Cancer Inst, vol.82, pp.22-31, 1990.

R. De-lange, N. Dimoudis, and U. H. Weidle, Identification of genes associated with enhanced metastasis of a large cell lung carcinoma cell line, Anticancer Res, vol.23, pp.187-94, 2003.

T. W. Moody, J. Chiles, M. Casibang, E. Moody, D. Chan et al., SR48692 is a neurotensin receptor antagonist which inhibits the growth of small cell lung cancer cells, Peptides, vol.22, pp.109-124, 2001.

D. Zhao, A. C. Keates, S. Kuhnt-moore, M. P. Moyer, C. P. Kelly et al., Signal transduction pathways mediating neurotensin-stimulated interleukin-8 expression in human colonocytes, J Biol Chem, vol.276, pp.44464-71, 2001.

N. A. Banker, M. R. Hellmich, H. J. Kim, C. M. Townsend, J. Evers et al., Src-mediated activation of the human neurotensin/neuromedin N promoter, Surgery, vol.122, pp.180-185, 1997.

J. M. Pellikainen, K. M. Ropponen, V. V. Kataja, J. K. Kellokoski, M. J. Eskelinen et al., Expression of matrix metalloproteinase (MMP)-2 and MMP-9 in breast cancer with a special reference to activator protein-2, HER2, and prognosis, Clin Cancer Res, vol.10, pp.7621-7629, 2004.

F. Souazé, S. Dupouy, and V. Viardot-foucault,