L. J. Rizzolo, Development and role of tight junctions in the retinal pigment epithelium, Int Rev Cytol, vol.258, pp.195-234, 2007.

R. W. Young, Visual cells and the concept of renewal, Invest Ophthalmol Vis Sci, vol.15, pp.700-725, 1976.

O. Strauss, The retinal pigment epithelium in visual function, Physiol Rev, vol.85, pp.845-81, 2005.

T. Sarna, Properties and function of the ocular melanin-a photobiophysical view, J Photochem Photobiol, B, vol.12, pp.215-58, 1992.

W. M. Haddad, G. Coscas, and G. Soubrane, Agerelated macular degeneration and apoptosis, J Fr Ophtalmol, vol.26, pp.307-318, 2003.

M. A. Zarbin, Current concepts in the pathogenesis of age-related macular degeneration, Arch Ophthalmol, vol.122, pp.598-614, 2004.

S. K. West, F. S. Rosenthal, and N. M. Bressler, Exposure to sunlight and other risk factors for age-related macular degeneration, Arch Ophthalmol, vol.107, pp.875-884, 1989.

T. E. Clemons, R. C. Milton, and R. Klein, Risk factors for the incidence of Advanced Age-Related Macular Degeneration in the Age-Related Eye Disease Study (AREDS) AREDS report no. 19, Ophthalmology, vol.112, pp.533-542, 2005.

F. Jonasson, D. E. Fisher, and G. Eiriksdottir, Five-year incidence, progression, and risk factors for age-related macular degeneration: the age, gene/environment susceptibility study, Ophthalmology, vol.121, pp.1766-72, 2014.

C. Martinsons and G. Zissis, Potential Health Issues of Solid-State Lighting, SSL Annex. 3464 ª 2017 The Authors

Z. Zhao, T. Sun, and Y. Jiang, Photo-oxidative damage in retinal pigment epithelial cells via GRP78 and the protective role of grape skin polyphenols, Food Chem Toxicol, vol.74, pp.216-240, 2014.

F. Behar-cohen, C. Martinsons, and F. Vienot, Light-emitting diodes (LED) for domestic lighting: any risks for the eye?, Prog Retin Eye Res, vol.30, pp.239-57, 2011.
URL : https://hal.archives-ouvertes.fr/hal-00685942

I. Jaadane, P. Boulenguez, and S. Chahory, Retinal damage induced by commercial light emitting diodes (LEDs), Free Radic Biol Med, vol.84, pp.373-84, 2015.

A. Krigel, M. Berdugo, and E. Picard, Lightinduced retinal damage using different light sources, protocols and rat strains reveals LED phototoxicity, Neuroscience, vol.339, pp.296-307, 2016.
URL : https://hal.archives-ouvertes.fr/hal-01383394

D. Sliney, A. , D. Delori, and F. , Adjustment of guidelines for exposure of the eye to optical radiation from ocular instruments: statement from a task group of the International Commission on Non-Ionizing Radiation Protection (ICNIRP), Appl Opt, vol.44, pp.2162-76, 2005.

W. T. Ham and H. A. Mueller, The photopathology and nature of the blue light and near-UV retinal lesions produced by lasers and other optical sources, Laser Applications in Medicine and Biology, pp.191-246, 1989.

, International Commission on Non-Ionizing Radiation Protection. ICNIRP Guidelines on limits of exposure to incoherent visible and infrared radiation, Health Phys, vol.105, pp.74-96, 2013.

D. H. Sliney, Quantifying retinal irradiance levels in light damage experiments, Curr Eye Res, vol.3, pp.175-184, 1984.

D. Van-norren and T. G. Gorgels, The action spectrum of photochemical damage to the retina: a review of monochromatic threshold data, Photochem Photobiol, vol.87, pp.747-53, 2011.

A. Hughes, A schematic eye for the rat, Vision Res, vol.19, pp.569-88, 1979.

M. T. Block, A note on the refraction and image formation of the rat's eye, Vision Res, vol.9, pp.705-716, 1969.

T. G. Gorgels and D. Van-norren, Spectral transmittance of the rat lens, Vision Res, vol.32, pp.1509-1521, 1992.

T. J. Van-den-berg and K. E. Tan, Light transmittance of the human cornea from 320 to 700 nm for different ages, Vision Res, vol.34, pp.1453-1459, 1994.

M. E. Reyland, Protein kinase C isoforms: multi-functional regulators of cell life and death, Front Biosci (Landmark Ed), vol.14, pp.2386-99, 2009.

M. W. Wooten, G. Zhou, and M. L. Seibenhener, A role for zeta protein kinase C in nerve growth factor-induced differentiation of PC12 cells, Cell Growth Differ, vol.5, pp.395-403, 1994.

P. Crisanti, A. Leon, and D. M. Lim, Aspirin prevention of NMDA-induced neuronal death by direct protein kinase Czeta inhibition, J Neurochem, vol.93, pp.1587-93, 2005.
URL : https://hal.archives-ouvertes.fr/inserm-00146734

I. Jaadane, S. Chahory, and C. Lepretre, The activation of the atypical PKC zeta in light-induced retinal degeneration and its involvement in L-DNase II control, J Cell Mol Med, vol.19, pp.1646-55, 2015.
URL : https://hal.archives-ouvertes.fr/hal-01271030

P. Crisanti, O. Laplace, and E. Lecain, The role of PKCzeta in NMDA-induced retinal ganglion cell death: prevention by aspirin, Apoptosis, vol.11, pp.983-91, 2006.
URL : https://hal.archives-ouvertes.fr/inserm-00146748

S. Omri, F. Behar-cohen, and P. R. Rothschild, PKCzeta mediates breakdown of outer blood-retinal barriers in diabetic retinopathy, PLoS One, vol.8, p.81600, 2013.

L. Li, Y. Chen, and S. B. Gibson, Starvation-induced autophagy is regulated by mitochondrial reactive oxygen species leading to AMPK activation, Cell Signal, vol.25, pp.50-65, 2013.

I. P. Nezis and H. Stenmark, p62 at the interface of autophagy, oxidative stress signaling, and cancer, Antioxid Redox Signal, vol.17, pp.786-93, 2012.

L. Wang, M. Cano, and J. T. Handa, p62 provides dual cytoprotection against oxidative stress in the retinal pigment epithelium, Biochim Biophys Acta, vol.1843, pp.1248-58, 2014.

S. Pankiv, T. Lamark, and J. A. Bruun, Nucleocytoplasmic shuttling of p62/SQSTM1 and its role in recruitment of nuclear polyubiquitinated proteins to promyelocytic leukemia bodies, J Biol Chem, vol.285, pp.5941-53, 2010.

P. Saftig, W. Beertsen, and E. L. Eskelinen, LAMP-2: a control step for phagosome and autophagosome maturation, Autophagy, vol.4, pp.510-512, 2008.

I. R. Nabi and E. Rodriguez-boulan, Increased LAMP-2 polylactosamine glycosylation is associated with its slower Golgi transit during establishment of a polarized MDCK epithelial monolayer, Mol Biol Cell, vol.4, pp.627-662, 1993.

G. E. Villalpando-rodriguez and A. Torriglia, Calpain 1 induce lysosomal permeabilization by cleavage of lysosomal associated membrane protein 2, Biochim Biophys Acta, vol.1833, pp.2244-53, 2013.

A. Torriglia, I. Jaadane, and C. Lebon, Mechanisms of cell death in neurodegenerative and retinal diseases: common pathway?, Curr Opin Neurol, vol.29, pp.55-60, 2016.
URL : https://hal.archives-ouvertes.fr/hal-01292021

L. Galluzzi, O. Kepp, and G. Kroemer, RIP kinases initiate programmed necrosis, J Mol Cell Biol, vol.1, pp.8-10, 2009.

J. J. Hunter, J. I. Morgan, and W. H. Merigan, The susceptibility of the retina to photochemical damage from visible light, Prog Retin Eye Res, vol.31, pp.28-42, 2012.

D. T. Organisciak and D. K. Vaughan, Retinal light damage: mechanisms and protection, Prog Retin Eye Res, vol.29, pp.113-147, 2010.

W. K. Noell, Possible mechanisms of photoreceptor damage by light in mammalian eyes, Vision Res, vol.20, pp.1163-71, 1980.

C. Grimm, A. Wenzel, and F. Hafezi, Protection of Rpe65-deficient mice identifies rhodopsin as a mediator of light-induced retinal degeneration, Nat Genet, vol.25, pp.63-69, 2000.

E. Chamorro, C. Bonnin-arias, and M. J. Perez-carrasco, Effects of light-emitting diode radiations on human retinal pigment epithelial cells in vitro. Photochem Photobiol, vol.89, pp.468-73, 2013.

A. C. Starnes, C. Huisingh, and G. Mcgwin, Multi-nucleate retinal pigment epithelium cells of the human macula exhibit a characteristic and highly specific distribution, Vis Neurosci, vol.33, p.1, 2016.

T. Ach, C. Huisingh, and J. G. Mcgwin, Quantitative Autofluorescence and Cell Density Maps of the Human Retinal Pigment Epithe-liumRPE Autofluorescence and Cell Density, Invest Ophthalmol Vis Sci, vol.55, pp.4832-4873, 2014.

H. Yoshida, K. Haze, and H. Yanagi, Identification of the cis-acting endoplasmic reticulum stress response element responsible for transcriptional induction of mammalian glucose-regulated proteins. Involvement of basic leucine zipper transcription factors, J Biol Chem, vol.273, pp.33741-33750, 1998.

D. Ron and P. Walter, Signal integration in the endoplasmic reticulum unfolded protein response, Nat Rev Mol Cell Biol, vol.8, pp.519-548, 2007.

S. Janciauskiene, Conformational properties of serine proteinase inhibitors (serpins) confer multiple pathophysiological roles, Biochim Biophys Acta, vol.1535, pp.221-256, 2001.

L. Padron-barthe, J. Courta, and C. Lepretre, Leukocyte Elastase Inhibitor, the precursor of L-DNase II, inhibits apoptosis by interfering with caspase-8 activation, Biochim Biophys Acta, vol.1783, pp.1755-66, 2008.

C. Justet, F. Evans, and A. Torriglia, Increase in the expression of leukocyte elastase inhibitor during wound healing in ª 2017 The Authors, corneal endothelial cells. Cell Tissue Res, vol.362, pp.557-568, 2015.

A. Duran, M. T. Diaz-meco, and J. Moscat, Essential role of RelA Ser311 phosphorylation by zetaPKC in NF-kappaB transcriptional activation, EMBO J, vol.22, pp.3910-3918, 2003.

S. Jain, T. Suzuki, and A. Seth, Protein kinase Czeta phosphorylates occludin and promotes assembly of epithelial tight junctions, Biochem J, vol.437, pp.289-99, 2011.

L. Smith and J. B. Smith, Lack of constitutive activity of the free kinase domain of protein kinase C zeta. Dependence on transphosphorylation of the activation loop, J Biol Chem, vol.277, pp.45866-73, 2002.

L. Smith, L. Chen, and M. E. Reyland, Activation of atypical protein kinase C zeta by caspase processing and degradation by the ubiquitin-proteasome system, J Biol Chem, vol.275, pp.40620-40627, 2000.

L. Wang, K. B. Ebrahimi, and M. Chyn, Biology of p62/sequestosome-1 in Age-Related Macular Degeneration (AMD), Adv Exp Med Biol, vol.854, pp.17-22, 2016.

D. Sinha, M. Valapala, and P. Shang, Lysosomes: Regulators of autophagy in the retinal pigmented epithelium, Exp Eye Res, vol.144, pp.46-53, 2016.

C. Roehlecke, A. Schaller, and L. Knels, The influence of sublethal blue light exposure on human RPE cells, Mol Vis, vol.15, pp.1929-1967, 2009.

H. K. Lorenzo, S. A. Susin, and J. Penninger, Apoptosis inducing factor (AIF): a phylogenetically old, caspase-independent effector of cell death, Cell Death Differ, vol.6, pp.516-540, 1999.

L. Padron-barthe, C. Lepretre, and E. Martin, Conformational modification of serpins transforms leukocyte elastase inhibitor into an endonuclease involved in apoptosis, Mol Cell Biol, vol.27, pp.4028-4064, 2007.
URL : https://hal.archives-ouvertes.fr/inserm-00140748

S. Chahory, N. Keller, and E. Martin, Light induced retinal degeneration activates a caspase-independent pathway involving cathepsin D, Neurochem Int, vol.57, pp.278-87, 2010.

S. Chahory, L. Padron, and Y. Courtois, The LEI/L-DNase II pathway is activated in lightinduced retinal degeneration in rats, Neurosci Lett, vol.367, pp.205-214, 2004.
URL : https://hal.archives-ouvertes.fr/inserm-00143906

C. Brandstetter, L. K. Mohr, and E. Latz, Light induces NLRP3 inflammasome activation in retinal pigment epithelial cells via lipofuscinmediated photooxidative damage, J Mol Med (Berl), vol.93, pp.905-921, 2015.

T. Narimatsu, K. Negishi, and S. Miyake, Blue light-induced inflammatory marker expression in the retinal pigment epitheliumchoroid of mice and the protective effect of a yellow intraocular lens material in vivo, Exp Eye Res, vol.132, pp.48-51, 2015.

W. Chen, C. Wu, and Z. Xu, Nrf2 protects photoreceptor cells from photo-oxidative stress induced by blue light, Exp Eye Res, vol.154, pp.151-159, 2017.

M. Wang and R. J. Kaufman, Protein misfolding in the endoplasmic reticulum as a conduit to human disease, Nature, vol.529, pp.326-361, 2016.

D. Senft, UPR, autophagy, and mitochondria crosstalk underlies the ER stress response, Trends Biochem Sci, vol.40, pp.141-149, 2015.

I. Jorgensen, M. Rayamajhi, and E. A. Miao, Programmed cell death as a defence against infection, Nat Rev Immunol, vol.17, pp.151-164, 2017.

M. Chaves, T. Eissing, and A. , Regulation of Apoptosis via the NFjB Pathway: modeling and Analysis, Dynamics On and Of Complex Networks: applications to Biology, Computer Science, and the Social Sciences, pp.19-33, 2009.

G. Bjorkoy, T. Lamark, and A. Brech, p62/ SQSTM1 forms protein aggregates degraded by autophagy and has a protective effect on huntingtin-induced cell death, J Cell Biol, vol.171, pp.603-617, 2005.

T. U. Krohne, E. Kaemmerer, and F. G. Holz, Lipid peroxidation products reduce lysosomal protease activities in human retinal pigment epithelial cells via two different mechanisms of action, Exp Eye Res, vol.90, pp.261-267, 2010.

J. Hanus, C. Anderson, and S. Wang, RPE necroptosis in response to oxidative stress and in AMD, Ageing Res Rev, vol.24, pp.286-98, 2015.