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Extensive exploration of a novel rat model of Parkinson's disease using partial 6-hydroxydopamine lesion of dopaminergic neurons suggests new therapeutic approaches

Abstract : Parkinson's disease (PD) is characterized by the degeneration of dopaminergic (DA) neurons constituting the nigrostriatal pathway. Neuroinflammation, related to microglial activation, plays an important role in this process. Exploration of animal models of PD using neuroimaging modalities allows to better understand the pathophysiology of the disease. Here, we fully explored a moderate lesion model in the rat in which 6-Synapse
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https://www.hal.inserm.fr/inserm-02458381
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Steven Vetel, Sophie Serriere, Johnny Vercouillie, Jackie Vergote, Gabrielle Chicheri, et al.. Extensive exploration of a novel rat model of Parkinson's disease using partial 6-hydroxydopamine lesion of dopaminergic neurons suggests new therapeutic approaches. Synapse, Wiley-Blackwell, 2019, 73 (3), pp.e22077. ⟨10.1002/syn.22077⟩. ⟨inserm-02458381⟩

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