Skip to Main content Skip to Navigation

Bone sarcomas in the immunotherapy era

Abstract : Bone sarcomas are primary bone tumours found mainly in children and adolescents, as osteosarcoma and Ewing's sarcoma, and in adults in their 40s as chondrosarcoma. The last four decades the development of therapeutic approaches was based on drug combinations have shown no real improvement in overall survival. Recently oncoimmunology has allowed a better understand of the crucial role played by the immune system in the oncologic process. This led to clinical trials with the aim of reprogramming the immune system to facilitate cancer cell recognition. Immune infiltrates of bone sarcomas have been characterized and their molecular profiling identified as immune therapeutic targets. Unfortunately, the clinical responses in trials remain anecdotal but highlight the necessity to improve the characterization of tumour micro-environment to unlock the immunotherapeutic response, especially in their paediatric forms. Bone sarcomas have entered the immunotherapy era and here we overview the recent developments in immunotherapies in these sarcomas.
Complete list of metadatas

Cited literature [134 references]  Display  Hide  Download

https://www.hal.inserm.fr/inserm-02458301
Contributor : Dominique Heymann <>
Submitted on : Tuesday, January 28, 2020 - 3:58:32 PM
Last modification on : Friday, February 21, 2020 - 1:37:21 AM

File

 Restricted access
To satisfy the distribution rights of the publisher, the document is embargoed until : 2020-07-23

Please log in to resquest access to the document

Identifiers

Citation

Marie-Françoise Heymann, Kristina Schiavone, Dominique Heymann. Bone sarcomas in the immunotherapy era. British Journal of Pharmacology, Wiley, 2020, Epub ahead of print. ⟨10.1111/bph.14999⟩. ⟨inserm-02458301⟩

Share

Metrics

Record views

33