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Bone sarcomas in the immunotherapy era

Abstract : Bone sarcomas are primary bone tumours found mainly in children and adolescents, as osteosarcoma and Ewing's sarcoma, and in adults in their 40s as chondrosarcoma. The last four decades the development of therapeutic approaches was based on drug combinations have shown no real improvement in overall survival. Recently oncoimmunology has allowed a better understand of the crucial role played by the immune system in the oncologic process. This led to clinical trials with the aim of reprogramming the immune system to facilitate cancer cell recognition. Immune infiltrates of bone sarcomas have been characterized and their molecular profiling identified as immune therapeutic targets. Unfortunately, the clinical responses in trials remain anecdotal but highlight the necessity to improve the characterization of tumour micro-environment to unlock the immunotherapeutic response, especially in their paediatric forms. Bone sarcomas have entered the immunotherapy era and here we overview the recent developments in immunotherapies in these sarcomas.
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Submitted on : Tuesday, January 28, 2020 - 3:58:32 PM
Last modification on : Wednesday, April 27, 2022 - 3:56:59 AM
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Marie-Françoise Heymann, Kristina K Schiavone, Dominique Heymann. Bone sarcomas in the immunotherapy era. British Journal of Pharmacology, Wiley, 2020, Epub ahead of print. ⟨10.1111/bph.14999⟩. ⟨inserm-02458301⟩



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